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Generation of a human induced pluripotent stem cell line from a familial Alzheimer's disease PSEN1 T119I patient

Generation of a human induced pluripotent stem cell line from a familial Alzheimer's disease PSEN1 T119I patient

Isaja, Luciana; Rodríguez Varela, María Soledad; Marazita, Mariela Claudia; Mucci, Sofía; Itzcovich, Tatiana; Chrem Méndez, Patricio Alexis; Niikado, Matías; Ferriol Laffouillere, Sofía Luján; Allegri, Ricardo Francisco; Martinetto, Horacio; Sevlever, Gustavo Emilio; Scassa, María Élida; Surace, Ezequiel Ignacio; Romorini, Leonardo
URI: https://doi.org/10.1016/j.scr.2021.102325
https://repositorio.fleni.org.ar/xmlui/handle/123456789/406
Fecha: 2021-04-05

Resumen:

Human induced pluripotent stem cells (hiPSC) line FLENIi001-A was reprogrammed from dermal fibroblasts using the lentiviral-hSTEMCCA-loxP vector. Fibroblasts were obtained from a skin biopsy of a 72-year-old Caucasian male familial Alzheimer's disease patient carrying the T119I mutation in the PSEN1 gene. PSEN1 genotype was maintained and stemness and pluripotency confirmed in the FLENIi001-A hiPSC line.

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