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dc.contributor.author | Marrodán, Mariano | |
dc.contributor.author | Farez, Mauricio Franco | |
dc.contributor.author | Balbuena Aguirre, María Eugenia | |
dc.contributor.author | Correale, Jorge | |
dc.date.accessioned | 2021-04-26T12:04:42Z | |
dc.date.available | 2021-04-26T12:04:42Z | |
dc.date.issued | 2021-02 | |
dc.identifier.citation | 80. Marrodan M, Farez MF, Balbuena Aguirre ME, Correale J. Obesity and the risk of Multiple Sclerosis. The role of Leptin. Ann Clin Transl Neurol. Ann Clin Transl Neurol. 2021 Feb;8(2):406-424. doi: 10.1002/acn3.51291. Epub 2020 Dec 28. | es_ES |
dc.identifier.uri | https://repositorio.fleni.org.ar/xmlui/handle/123456789/435 | |
dc.identifier.uri | https://doi.org/10.1002/acn3.51291 | |
dc.description.abstract | Objective: To investigate the effects of leptin on different T-cell populations, in order to gain more insight into the link between leptin and obesity. Methods: Three hundred and nine RRMS patients and 322 controls participated in a cross-sectional survey, to confirm whether excess weight/obesity in adolescence or early adulthood increased the risk of MS. Serum leptin levels were determined by ELISA. MBP83-102 , and MOG63-87 peptide-specific T cells lines were expanded from peripheral blood mononuclear cells. Leptin receptor expression was measured by RT-PCR and flow cytometry. Bcl-2, p-STAT3, pERK1/2, and p27kip1 expression were assayed using ELISA, and apoptosis induction was determined by Annexin V detection. Cytokines were assessed by ELISPOT and ELISA, and regulatory T cells (Tregs) by flow cytometry. Results: Logistic regression analysis, showed excess weight at age 15, and obesity at 20 years of age increased MS risk (OR = 2.16, P = 0.01 and OR = 3.9, P = 0.01). Leptin levels correlated with BMI in both groups. The addition of Leptin increased autoreactive T-cell proliferation, reduced apoptosis induction, and promoted proinflammatory cytokine secretion. Obese patients produced more proinflammatory cytokines compared to overweight/normal/underweight subjects. Inverse correlation was found between leptin levels and circulating Treg cells (r = -0.97, P < 0.0001). Leptin inhibited Treg proliferation. Effects of leptin on CD4+ CD25- effector T cells were mediated by increased STAT3 and ERK1/2 phosphorylation, and down modulation of the cell cycle inhibitor P27kip1 . In contrast, leptin effects on Tregs resulted from decreased phosphorylation of ERK1/2 and upregulation of p27kip1 . Interpretation: Leptin promotes autoreactive T-cell proliferation and proinflammatory cytokine secretion, but inhibits Treg-cell proliferation. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Wiley Periodicals | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by/2.5/ar/ | |
dc.subject | Multiple Sclerosis | es_ES |
dc.subject | Obesity | es_ES |
dc.subject | Obesidad | es_ES |
dc.subject | Esclerosis Múltiple | es_ES |
dc.title | Obesity and the risk of Multiple Sclerosis. The role of Leptin | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.type | info:eu-repo/semantics/publishedVersion | |
dc.description.fil | Fil: Marrodán, Mariano. Fleni. Departamento de Neurología. Servicio de Neuroinmunología y Enfermedades Desmielinizantes; Argentina. | |
dc.description.fil | Fil: Farez, Mauricio Franco. Fleni. Departamento de Neurología; Argentina. | |
dc.description.fil | Fil: Correale, Jorge. Fleni. Departamento de Neurología. Servicio de Neuroinmunología y Enfermedades Desmielinizantes; Argentina. | |
dc.description.fil | Fil: Balbuena Aguirre, María Eugenia. Hospital de Clínicas José de San Martín. Departamento de Neurología; Argentina. | |
dc.relation.ispartofVOLUME | 8 | |
dc.relation.ispartofNUMBER | 2 | |
dc.relation.ispartofPAGINATION | 406-424 | |
dc.relation.ispartofCOUNTRY | Estados Unidos | |
dc.relation.ispartofCITY | Nueva Jersey | |
dc.relation.ispartofTITLE | Annals of clinical and translational neurology | |
dc.relation.ispartofISSN | 2328-9503 | |
dc.type.snrd | info:ar-repo/semantics/artículo | es_ES |