Biphasic cortical macro- and microstructural changes in autosomal dominant Alzheimer's disease

Montal, Victor; Vilaplana, Eduard; Pegueroles, Jordi; Bejanin, Alexandre; Alcolea, Daniel; Carmona-Iragui, María; Clarimón, Jordi; Levin, Johannes; Cruchaga, Carlos; Graff-Radford, Neill R.; Noble, James M.; Lee, Jae-Hong; Allegri, Ricardo Francisco; Karch, Celeste M.; Laske, Christoph; Schofield, Peter R.; Salloway, Stephen; Ances, Beau M.; Benzinger, Tammie L.S.; McDade, Eric; Bateman, Randall J.; Blesa, Rafael; Sánchez-Valle, Raquel; Lleó, Alberto; Fortea, Juan; Dominantly Inherited Alzheimer Network

dc.contributor.author	Montal, Victor
dc.contributor.author	Vilaplana, Eduard
dc.contributor.author	Pegueroles, Jordi
dc.contributor.author	Bejanin, Alexandre
dc.contributor.author	Alcolea, Daniel
dc.contributor.author	Carmona-Iragui, María
dc.contributor.author	Clarimón, Jordi
dc.contributor.author	Levin, Johannes
dc.contributor.author	Cruchaga, Carlos
dc.contributor.author	Graff-Radford, Neill R.
dc.contributor.author	Noble, James M.
dc.contributor.author	Lee, Jae-Hong
dc.contributor.author	Allegri, Ricardo Francisco
dc.contributor.author	Karch, Celeste M.
dc.contributor.author	Laske, Christoph
dc.contributor.author	Schofield, Peter R.
dc.contributor.author	Salloway, Stephen
dc.contributor.author	Ances, Beau M.
dc.contributor.author	Benzinger, Tammie L.S.
dc.contributor.author	McDade, Eric
dc.contributor.author	Bateman, Randall J.
dc.contributor.author	Blesa, Rafael
dc.contributor.author	Sánchez-Valle, Raquel
dc.contributor.author	Lleó, Alberto
dc.contributor.author	Fortea, Juan
dc.contributor.author	Dominantly Inherited Alzheimer Network
dc.date.accessioned	2021-04-29T12:21:30Z
dc.date.available	2021-04-29T12:21:30Z
dc.date.issued	2020-11-16
dc.identifier.citation	Montal, V., Vilaplana, E., Pegueroles, J., Bejanin, A., Alcolea, D., Carmona-Iragui, M., Clarimón, J., Levin, J., Cruchaga, C., Graff-Radford, N.R., Noble, J.M., Lee, J.-H., Allegri, R., Karch, C.M., Laske, C., Schofield, P.R., Salloway, S., Ances, B., Benzinger, T., McDale, E., Bateman, R., Blesa, R., Sánchez-Valle, R., Lleó, A., Fortea, J., 2020. Biphasic cortical macro- and microstructural changes in autosomal dominant Alzheimer’s disease. Alzheimers Dement. https://doi.org/10.1002/alz.12224	es_ES
dc.identifier.uri	https://repositorio.fleni.org.ar/xmlui/handle/123456789/441
dc.identifier.uri	https://doi.org/10.1002/alz.12224
dc.description.abstract	Methods: In this study we tested this model fitting linear versus quadratic trajectories and computed the timing of the inflection points vertexwise of cortical thickness and cortical diffusivity-a novel marker of cortical microstructure-changes in 389 participants from the Dominantly Inherited Alzheimer Network. Results: In early preclinical AD, between 20 and 15 years before estimated symptom onset, we found increases in cortical thickness and decreases in cortical diffusivity followed by cortical thinning and cortical diffusivity increases in later preclinical and symptomatic stages. The inflection points 16 to 19 years before estimated symptom onset are in agreement with the start of tau biomarker alterations. Discussion: These findings confirm a biphasic trajectory for brain structural changes and have direct implications when interpreting magnetic resonance imaging measures in preventive AD clinical trials.	es_ES
dc.language.iso	eng	es_ES
dc.publisher	John Wiley & Sons	es_ES
dc.rights	info:eu-repo/semantics/openAccess
dc.rights.uri	https://creativecommons.org/licenses/by/2.5/ar/
dc.subject	Enfermedad de Alzheimer	es_ES
dc.subject	Alzheimer Disease	es_ES
dc.title	Biphasic cortical macro- and microstructural changes in autosomal dominant Alzheimer's disease	es_ES
dc.type	info:eu-repo/semantics/article	es_ES
dc.type	info:eu-repo/semantics/publishedVersion
dc.description.fil	Fil: Allegri, Ricardo Francisco. Fleni. Departamento de Neurología. Servicio de Neurología Cognitiva, Neuropsicología y Neuropsiquiatría; Argentina.
dc.description.fil	Fil: Montal, Victor. Universitat Autònoma de Barcelona. Biomedical Research Institute Sant Pau. Hospital de la Santa Creu i Sant Pau. Sant Pau Memory Unit, Department of Neurology; España. Center of Biomedical Investigation Network for Neurodegenerative Diseases (CIBERNED); España.
dc.description.fil	Fil: Vilaplana, Eduard. Universitat Autònoma de Barcelona. Biomedical Research Institute Sant Pau. Hospital de la Santa Creu i Sant Pau. Sant Pau Memory Unit, Department of Neurology; España. Center of Biomedical Investigation Network for Neurodegenerative Diseases (CIBERNED); España.
dc.description.fil	Fil: Pegueroles, Jordi. Universitat Autònoma de Barcelona. Biomedical Research Institute Sant Pau. Hospital de la Santa Creu i Sant Pau. Sant Pau Memory Unit, Department of Neurology; España. Center of Biomedical Investigation Network for Neurodegenerative Diseases (CIBERNED); España.
dc.description.fil	Fil: Bejanin, Alexandre. Universitat Autònoma de Barcelona. Biomedical Research Institute Sant Pau. Hospital de la Santa Creu i Sant Pau. Sant Pau Memory Unit, Department of Neurology; España. Center of Biomedical Investigation Network for Neurodegenerative Diseases (CIBERNED); España.
dc.description.fil	Fil: Alcolea, Daniel. Universitat Autònoma de Barcelona. Biomedical Research Institute Sant Pau. Hospital de la Santa Creu i Sant Pau. Sant Pau Memory Unit, Department of Neurology; España. Center of Biomedical Investigation Network for Neurodegenerative Diseases (CIBERNED); España.
dc.description.fil	Fil: Carmona-Iragui, María. Universitat Autònoma de Barcelona. Biomedical Research Institute Sant Pau. Hospital de la Santa Creu i Sant Pau. Sant Pau Memory Unit, Department of Neurology; España. Center of Biomedical Investigation Network for Neurodegenerative Diseases (CIBERNED); España. Fundació Catalana de Síndrome de Down. Barcelona Down Medical Center; España.
dc.description.fil	Fil: Clarimón, Jordi. Universitat Autònoma de Barcelona. Biomedical Research Institute Sant Pau. Hospital de la Santa Creu i Sant Pau. Sant Pau Memory Unit, Department of Neurology; España. Center of Biomedical Investigation Network for Neurodegenerative Diseases (CIBERNED); España.
dc.description.fil	Fil: Lleó, Alberto. Universitat Autònoma de Barcelona. Biomedical Research Institute Sant Pau. Hospital de la Santa Creu i Sant Pau. Sant Pau Memory Unit, Department of Neurology; España. Center of Biomedical Investigation Network for Neurodegenerative Diseases (CIBERNED); España.
dc.description.fil	Fil: Fortea, Juan. Universitat Autònoma de Barcelona. Biomedical Research Institute Sant Pau. Hospital de la Santa Creu i Sant Pau. Sant Pau Memory Unit, Department of Neurology; España. Center of Biomedical Investigation Network for Neurodegenerative Diseases (CIBERNED); España. Fundació Catalana de Síndrome de Down. Barcelona Down Medical Center; España.
dc.description.fil	Fil: Levin, Johannes. Ludwig-Maximilians-Universität München. Department of Neurology; Alemania. Munich Cluster for Systems Neurology (SyNergy). German Center for Neurodegenerative Diseases; Alemania.
dc.description.fil	Fil: Cruchaga, Carlos. Washington University School of Medicine. Department of Neurology; Estados Unidos. The Hope Center for Neurological Disorders; Estados Unidos. Washington University School of Medicine. NeuroGenomics and Informatics; Estados Unidos. Washington University School of Medicine. Knight Alzheimer's Disease Research Center; Estados Unidos.
dc.description.fil	Fil: Graff-Radford, Neill R. Mayo Clinic. Department of Neurology; Estados Unidos.
dc.description.fil	Fil: Noble, James M. Columbia University Irving Medical Center. Taub Institute for Research on Alzheimer's Disease and the Aging Brain. Department of Neurology; Estados Unidos.
dc.description.fil	Fil: Lee, Jae-Hong. University of Ulsan College of Medicine. Asan Medical Center. Department of Neurology; Corea.
dc.description.fil	Fil: Karch, Celeste M. Washington University School of Medicine. Department of Psychiatry; Estados Unidos.
dc.description.fil	Fil: Laske, Christoph. German Center for Neurodegenerative Diseases (DZNE); Alemania. University of Tübingen. Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy. Section for Dementia Research; Alemania.
dc.description.fil	Fil: Schofield, Peter R. Neuroscience Research Australia; Australia. University of New South Wales. School of Medical Sciences; Australia.
dc.description.fil	Fil: Salloway, Stephen. Butler Hospital. Neurology and the Memory and Aging Program; Estados Unidos.
dc.description.fil	Fil: Ances, Beau. Washington University School of Medicine. Department of Neurology; Estados Unidos. The Hope Center for Neurological Disorders; Estados Unidos. Washington University School of Medicine. Knight Alzheimer's Disease Research Center; Estados Unidos. Washington University in St. Louis. Department of Radiology; Estados Unidos.
dc.description.fil	Fil: Benzinger, Tammie L.S. Washington University School of Medicine. Knight Alzheimer's Disease Research Center; Estados Unidos. Washington University in St. Louis. Department of Radiology; Estados Unidos.
dc.description.fil	Fil: McDale, Eric. Washington University School of Medicine. Knight Alzheimer's Disease Research Center; Estados Unidos. Washington University School of Medicine. Department of Neurology; Estados Unidos.
dc.description.fil	Fil: Bateman, Randall J. Washington University School of Medicine. Department of Neurology; Estados Unidos. The Hope Center for Neurological Disorders; Estados Unidos. Washington University School of Medicine. Knight Alzheimer's Disease Research Center; Estados Unidos.
dc.description.fil	Fil: Blesa, Rafael. Universitat Autònoma de Barcelona. Biomedical Research Institute Sant Pau. Hospital de la Santa Creu i Sant Pau. Sant Pau Memory Unit, Department of Neurology; España. Center of Biomedical Investigation Network for Neurodegenerative Diseases (CIBERNED); España.
dc.description.fil	Fil: Sánchez-Valle, Raquel. Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS). Fundació Clínic per a la Recerca Biomèdica. Hospital Clínic. Alzheimer's Disease and Other Cognitive Disorders Unit; España.
dc.relation.ispartofCOUNTRY	Estados Unidos
dc.relation.ispartofCITY	Nueva York
dc.relation.ispartofTITLE	Alzheimer's & dementia : the journal of the Alzheimer's Association.
dc.relation.ispartofISSN	1552-5279
dc.type.snrd	info:ar-repo/semantics/artículo	es_ES