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Biphasic cortical macro- and microstructural changes in autosomal dominant Alzheimer's disease

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dc.contributor.author Montal, Victor
dc.contributor.author Vilaplana, Eduard
dc.contributor.author Pegueroles, Jordi
dc.contributor.author Bejanin, Alexandre
dc.contributor.author Alcolea, Daniel
dc.contributor.author Carmona-Iragui, María
dc.contributor.author Clarimón, Jordi
dc.contributor.author Levin, Johannes
dc.contributor.author Cruchaga, Carlos
dc.contributor.author Graff-Radford, Neill R.
dc.contributor.author Noble, James M.
dc.contributor.author Lee, Jae-Hong
dc.contributor.author Allegri, Ricardo Francisco
dc.contributor.author Karch, Celeste M.
dc.contributor.author Laske, Christoph
dc.contributor.author Schofield, Peter R.
dc.contributor.author Salloway, Stephen
dc.contributor.author Ances, Beau M.
dc.contributor.author Benzinger, Tammie L.S.
dc.contributor.author McDade, Eric
dc.contributor.author Bateman, Randall J.
dc.contributor.author Blesa, Rafael
dc.contributor.author Sánchez-Valle, Raquel
dc.contributor.author Lleó, Alberto
dc.contributor.author Fortea, Juan
dc.contributor.author Dominantly Inherited Alzheimer Network
dc.date.accessioned 2021-04-29T12:21:30Z
dc.date.available 2021-04-29T12:21:30Z
dc.date.issued 2020-11-16
dc.identifier.citation Montal, V., Vilaplana, E., Pegueroles, J., Bejanin, A., Alcolea, D., Carmona-Iragui, M., Clarimón, J., Levin, J., Cruchaga, C., Graff-Radford, N.R., Noble, J.M., Lee, J.-H., Allegri, R., Karch, C.M., Laske, C., Schofield, P.R., Salloway, S., Ances, B., Benzinger, T., McDale, E., Bateman, R., Blesa, R., Sánchez-Valle, R., Lleó, A., Fortea, J., 2020. Biphasic cortical macro- and microstructural changes in autosomal dominant Alzheimer’s disease. Alzheimers Dement. https://doi.org/10.1002/alz.12224 es_ES
dc.identifier.uri https://repositorio.fleni.org.ar/xmlui/handle/123456789/441
dc.identifier.uri https://doi.org/10.1002/alz.12224
dc.description.abstract Methods: In this study we tested this model fitting linear versus quadratic trajectories and computed the timing of the inflection points vertexwise of cortical thickness and cortical diffusivity-a novel marker of cortical microstructure-changes in 389 participants from the Dominantly Inherited Alzheimer Network. Results: In early preclinical AD, between 20 and 15 years before estimated symptom onset, we found increases in cortical thickness and decreases in cortical diffusivity followed by cortical thinning and cortical diffusivity increases in later preclinical and symptomatic stages. The inflection points 16 to 19 years before estimated symptom onset are in agreement with the start of tau biomarker alterations. Discussion: These findings confirm a biphasic trajectory for brain structural changes and have direct implications when interpreting magnetic resonance imaging measures in preventive AD clinical trials. es_ES
dc.language.iso eng es_ES
dc.publisher John Wiley & Sons es_ES
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by/2.5/ar/
dc.subject Enfermedad de Alzheimer es_ES
dc.subject Alzheimer Disease es_ES
dc.title Biphasic cortical macro- and microstructural changes in autosomal dominant Alzheimer's disease es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.type info:eu-repo/semantics/publishedVersion
dc.description.fil Fil: Allegri, Ricardo Francisco. Fleni. Departamento de Neurología. Servicio de Neurología Cognitiva, Neuropsicología y Neuropsiquiatría; Argentina.
dc.description.fil Fil: Montal, Victor. Universitat Autònoma de Barcelona. Biomedical Research Institute Sant Pau. Hospital de la Santa Creu i Sant Pau. Sant Pau Memory Unit, Department of Neurology; España. Center of Biomedical Investigation Network for Neurodegenerative Diseases (CIBERNED); España.
dc.description.fil Fil: Vilaplana, Eduard. Universitat Autònoma de Barcelona. Biomedical Research Institute Sant Pau. Hospital de la Santa Creu i Sant Pau. Sant Pau Memory Unit, Department of Neurology; España. Center of Biomedical Investigation Network for Neurodegenerative Diseases (CIBERNED); España.
dc.description.fil Fil: Pegueroles, Jordi. Universitat Autònoma de Barcelona. Biomedical Research Institute Sant Pau. Hospital de la Santa Creu i Sant Pau. Sant Pau Memory Unit, Department of Neurology; España. Center of Biomedical Investigation Network for Neurodegenerative Diseases (CIBERNED); España.
dc.description.fil Fil: Bejanin, Alexandre. Universitat Autònoma de Barcelona. Biomedical Research Institute Sant Pau. Hospital de la Santa Creu i Sant Pau. Sant Pau Memory Unit, Department of Neurology; España. Center of Biomedical Investigation Network for Neurodegenerative Diseases (CIBERNED); España.
dc.description.fil Fil: Alcolea, Daniel. Universitat Autònoma de Barcelona. Biomedical Research Institute Sant Pau. Hospital de la Santa Creu i Sant Pau. Sant Pau Memory Unit, Department of Neurology; España. Center of Biomedical Investigation Network for Neurodegenerative Diseases (CIBERNED); España.
dc.description.fil Fil: Carmona-Iragui, María. Universitat Autònoma de Barcelona. Biomedical Research Institute Sant Pau. Hospital de la Santa Creu i Sant Pau. Sant Pau Memory Unit, Department of Neurology; España. Center of Biomedical Investigation Network for Neurodegenerative Diseases (CIBERNED); España. Fundació Catalana de Síndrome de Down. Barcelona Down Medical Center; España.
dc.description.fil Fil: Clarimón, Jordi. Universitat Autònoma de Barcelona. Biomedical Research Institute Sant Pau. Hospital de la Santa Creu i Sant Pau. Sant Pau Memory Unit, Department of Neurology; España. Center of Biomedical Investigation Network for Neurodegenerative Diseases (CIBERNED); España.
dc.description.fil Fil: Lleó, Alberto. Universitat Autònoma de Barcelona. Biomedical Research Institute Sant Pau. Hospital de la Santa Creu i Sant Pau. Sant Pau Memory Unit, Department of Neurology; España. Center of Biomedical Investigation Network for Neurodegenerative Diseases (CIBERNED); España.
dc.description.fil Fil: Fortea, Juan. Universitat Autònoma de Barcelona. Biomedical Research Institute Sant Pau. Hospital de la Santa Creu i Sant Pau. Sant Pau Memory Unit, Department of Neurology; España. Center of Biomedical Investigation Network for Neurodegenerative Diseases (CIBERNED); España. Fundació Catalana de Síndrome de Down. Barcelona Down Medical Center; España.
dc.description.fil Fil: Levin, Johannes. Ludwig-Maximilians-Universität München. Department of Neurology; Alemania. Munich Cluster for Systems Neurology (SyNergy). German Center for Neurodegenerative Diseases; Alemania.
dc.description.fil Fil: Cruchaga, Carlos. Washington University School of Medicine. Department of Neurology; Estados Unidos. The Hope Center for Neurological Disorders; Estados Unidos. Washington University School of Medicine. NeuroGenomics and Informatics; Estados Unidos. Washington University School of Medicine. Knight Alzheimer's Disease Research Center; Estados Unidos.
dc.description.fil Fil: Graff-Radford, Neill R. Mayo Clinic. Department of Neurology; Estados Unidos.
dc.description.fil Fil: Noble, James M. Columbia University Irving Medical Center. Taub Institute for Research on Alzheimer's Disease and the Aging Brain. Department of Neurology; Estados Unidos.
dc.description.fil Fil: Lee, Jae-Hong. University of Ulsan College of Medicine. Asan Medical Center. Department of Neurology; Corea.
dc.description.fil Fil: Karch, Celeste M. Washington University School of Medicine. Department of Psychiatry; Estados Unidos.
dc.description.fil Fil: Laske, Christoph. German Center for Neurodegenerative Diseases (DZNE); Alemania. University of Tübingen. Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy. Section for Dementia Research; Alemania.
dc.description.fil Fil: Schofield, Peter R. Neuroscience Research Australia; Australia. University of New South Wales. School of Medical Sciences; Australia.
dc.description.fil Fil: Salloway, Stephen. Butler Hospital. Neurology and the Memory and Aging Program; Estados Unidos.
dc.description.fil Fil: Ances, Beau. Washington University School of Medicine. Department of Neurology; Estados Unidos. The Hope Center for Neurological Disorders; Estados Unidos. Washington University School of Medicine. Knight Alzheimer's Disease Research Center; Estados Unidos. Washington University in St. Louis. Department of Radiology; Estados Unidos.
dc.description.fil Fil: Benzinger, Tammie L.S. Washington University School of Medicine. Knight Alzheimer's Disease Research Center; Estados Unidos. Washington University in St. Louis. Department of Radiology; Estados Unidos.
dc.description.fil Fil: McDale, Eric. Washington University School of Medicine. Knight Alzheimer's Disease Research Center; Estados Unidos. Washington University School of Medicine. Department of Neurology; Estados Unidos.
dc.description.fil Fil: Bateman, Randall J. Washington University School of Medicine. Department of Neurology; Estados Unidos. The Hope Center for Neurological Disorders; Estados Unidos. Washington University School of Medicine. Knight Alzheimer's Disease Research Center; Estados Unidos.
dc.description.fil Fil: Blesa, Rafael. Universitat Autònoma de Barcelona. Biomedical Research Institute Sant Pau. Hospital de la Santa Creu i Sant Pau. Sant Pau Memory Unit, Department of Neurology; España. Center of Biomedical Investigation Network for Neurodegenerative Diseases (CIBERNED); España.
dc.description.fil Fil: Sánchez-Valle, Raquel. Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS). Fundació Clínic per a la Recerca Biomèdica. Hospital Clínic. Alzheimer's Disease and Other Cognitive Disorders Unit; España.
dc.relation.ispartofCOUNTRY Estados Unidos
dc.relation.ispartofCITY Nueva York
dc.relation.ispartofTITLE Alzheimer's & dementia : the journal of the Alzheimer's Association.
dc.relation.ispartofISSN 1552-5279
dc.type.snrd info:ar-repo/semantics/artículo es_ES


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