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Aggressive multiple sclerosis in Argentina: Data from the nationwide registry RelevarEM

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dc.contributor.author Kohler, Matías
dc.contributor.author Kohler, Eduardo
dc.contributor.author Vrech, Carlos
dc.contributor.author Pappolla, Agustín
dc.contributor.author Miguez, Jimena
dc.contributor.author Patrucco, Liliana
dc.contributor.author Correale, Jorge
dc.contributor.author Marrodán, Mariano
dc.contributor.author Gaitán, María Inés
dc.contributor.author Fiol, Marcela Paula
dc.contributor.author Negrotto, Laura
dc.contributor.author Ysrraelit, María Célica
dc.contributor.author Cristiano, Edgardo
dc.contributor.author Carrá, Adriana
dc.contributor.author Steinberg, Judith
dc.contributor.author Martinez, Alejandra D.
dc.contributor.author Curbelo, María Celeste
dc.contributor.author Cohen, Leila
dc.contributor.author Alonso, Ricardo
dc.contributor.author Garcea, Orlando
dc.date.accessioned 2021-06-22T13:05:13Z
dc.date.available 2021-06-22T13:05:13Z
dc.date.issued 2021-06-01
dc.identifier.citation Kohler M, Kohler E, Vrech C, Pappolla A, Miguez J, Patrucco L, Correale J, Marrodan M, Gaitán MI, Fiol M, Negrotto L, Ysrraelit MC, Cristiano E, Carrá A, Steinberg J, Martinez AD, Curbelo MC, Cohen L, Alonso R, Garcea O, Pita C, Silva B, Luetic G, Deri N, Balbuena ME, Tkachuk V, Carnero Contentti E, Lopez PA, Pettinicchi JP, Caride A, Burgos M, Leguizamon F, Knorre E, Piedrabuena R, Barboza A, Liwacki S, Nofal P, Volman G, Alvez Pinheiro A, Hryb J, Tavolini D, Blaya P, Recchia L, Mainella C, Silva E, Blanche J, Tizio S, Saladino ML, Caceres F, Fernandez Liguori N, Lazaro L, Zanga G, Parada Marcilla M, Fracaro ME, Pagani Cassara F, Vazquez G, Sinay V, Sgrilli G, Divi P, Jacobo M, Reich E, Cabrera LM, Menichini ML, Coppola M, Martos I, Viglione JP, Jose G, Bestoso S, Manzi R, Giunta D, Doldan ML, Alonso Serena M, Rojas JI. Aggressive multiple sclerosis in Argentina: Data from the nationwide registry RelevarEM. J Clin Neurosci. 2021 Jun 1:S0967-5868(21)00265-4. doi: 10.1016/j.jocn.2021.05.047 es_ES
dc.identifier.uri https://doi.org/10.1016/j.jocn.2021.05.047
dc.identifier.uri https://repositorio.fleni.org.ar/xmlui/handle/123456789/497
dc.description.abstract The objectives of the present study were to describe the frequency of aggressive multiple sclerosis (aMS) as well as to compare clinical and radiological characteristics in aMS and non-aMS patients included in RelevarEM (NCT 03375177). Methods The eligible study population and cohort selection included adult-onset patients (≥18 years) with definite MS. AMS were defined as those reaching confirmed EDSS ≥ 6 within 5 years from symptom onset. Confirmation was achieved when a subsequent EDSS ≥ 6 was recorded at least six months later but within 5 years of the first clinical presentation. AMS and non-aMS were compared using the χ2 test for categorical and the Mann-Whitney for continuous variables at MS onset and multivariable analysis was performed using forward stepwise logistic regression with baseline characteristics at disease onset. Results A total of 2158 patients with MS were included: 74 aMS and 2084 non-aMS. The prevalence of aMS in our cohort was 3.4% (95%CI 2.7–4.2). AMS were more likely to be male (p = 0.003), older at MS onset (p < 0.001), have primary progressive MS (PPMS) phenotype (p = 0.03), multifocal presentation (p < 0.001), and spinal cord as well as infratentorial lesions at MRI during disease onset (p = 0.004 and p = 0.002, respectively). Conclusion 3.4% of our patient population could be considered aMS. Men, patients older at symptom onset, multifocal presentation, PPMS phenotype, and spinal cord as well as brainstem lesions on MRI at clinical presentation all had higher odds of having aMS. es_ES
dc.language.iso eng es_ES
dc.publisher Elsevier es_ES
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by/2.5/ar/
dc.subject Multiple Sclerosis es_ES
dc.subject Esclerosis Múltiple es_ES
dc.subject Argentina es_ES
dc.title Aggressive multiple sclerosis in Argentina: Data from the nationwide registry RelevarEM es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.type info:eu-repo/semantics/publishedVersion
dc.description.fil Fil: Kohler, Matías. Fundación Sinapsis Santa Rosa; Argentina.
dc.description.fil Fil: Kohler, Eduardo. Fundación Sinapsis Santa Rosa; Argentina.
dc.description.fil Fil: Vrech, Carlos. Sanatorio Allende; Argentina.
dc.description.fil Fil: Pappolla, Agustín. Hospital Italiano de Buenos Aires; Argentina.
dc.description.fil Fil: Miguez, Jimena. Hospital Italiano de Buenos Aires; Argentina.
dc.description.fil Fil: Patrucco, Liliana. Hospital Italiano de Buenos Aires; Argentina.
dc.description.fil Fil: Correale, Jorge. Fleni. Departamento de Neurología. Servicio de Neuroinmunología y Enfermedades Desmielinizantes; Argentina
dc.description.fil Fil: Marrodán, Mariano. Fleni. Departamento de Neurología. Servicio de Neuroinmunología y Enfermedades Desmielinizantes; Argentina
dc.description.fil Fil: Gaitán, María Inés. Fleni. Departamento de Neurología. Servicio de Neuroinmunología y Enfermedades Desmielinizantes; Argentina.
dc.description.fil Fil: Fiol, Marcela Paula. Fleni. Departamento de Neurología. Servicio de Neuroinmunología y Enfermedades Desmielinizantes; Argentina.
dc.description.fil Fil: Negrotto, Laura. Fleni. Departamento de Neurología. Servicio de Neuroinmunología y Enfermedades Desmielinizantes; Argentina.
dc.description.fil Fil: Ysrraelit, María Célica. Fleni. Departamento de Neurología. Servicio de Neuroinmunología y Enfermedades Desmielinizantes; Argentina.
dc.description.fil Fil: Cristiano, Edgardo. Centro de esclerosis múltiple de Buenos Aires; Argentina.
dc.description.fil Fil: Carrá, Adriana. Hospital Británico; Argentina.
dc.description.fil Fil: Steinberg, Judith. Hospital Británico; Argentina.
dc.description.fil Fil: Martinez, Alejandra D. Hospital Británico; Argentina.
dc.description.fil Fil: Curbelo, María Celeste. Hospital Británico; Argentina.
dc.description.fil Fil: Cohen, Leila. Hospital Dr. J. M. Ramos Mejía; Argentina.
dc.description.fil Fil: Alonso, Ricardo. Hospital Dr. J. M. Ramos Mejía; Argentina.
dc.description.fil Fil: Garcea, Orlando. Hospital Dr. J. M. Ramos Mejía; Argentina.
dc.relation.ispartofVOLUME 89
dc.relation.ispartofPAGINATION 360-364
dc.relation.ispartofCOUNTRY Reino Unido
dc.relation.ispartofCITY Edimburgo
dc.relation.ispartofTITLE Journal of clinical neuroscience
dc.relation.ispartofISSN 1532-2653
dc.type.snrd info:ar-repo/semantics/artículo es_ES


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