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Bundle-specific associations between white matter microstructure and Ab and tau pathology in preclinical Alzheimer’s disease

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dc.contributor.author Pichet Binette, Alexa
dc.contributor.author Theaud, Guillaume
dc.contributor.author Rheault, François
dc.contributor.author Roy, Maggie
dc.contributor.author Collins, D. Louis
dc.contributor.author Levin, Johannes
dc.contributor.author Mori, Hiroshi
dc.contributor.author Lee, Hae Hong
dc.contributor.author Rhys Farlow, Martin
dc.contributor.author Schofield, Peter R.
dc.contributor.author Chhatwal, Jasmeer P.
dc.contributor.author Masters, Colin L.
dc.contributor.author Benzinger, Tammie L.S.
dc.contributor.author Morris, John C.
dc.contributor.author Bateman, Randall J.
dc.contributor.author Breitner, John C.S.
dc.contributor.author Poirier, Judes
dc.contributor.author Allegri, Ricardo Francisco
dc.contributor.author DIAN Study Group
dc.contributor.author PREVENT-AD Research Group
dc.date.accessioned 2021-06-30T13:24:56Z
dc.date.available 2021-06-30T13:24:56Z
dc.date.issued 2021-05-13
dc.identifier.citation Pichet Binette A, Theaud G, Rheault F, Roy M, Collins DL, Levin J, Mori H, Lee JH, Farlow MR, Schofield PR, Chhatwal JP, Masters CL, Benzinger T, Morris JC, Bateman R, Breitner JC, Poirier J, Gonneaud J, Descoteaux M, Villeneuve S; DIAN Study Group; PREVENT-AD Research Group. Bundle-specific associations between white matter microstructure and Aβ and tau pathology in preclinical Alzheimer's disease. Elife. 2021 May 13;10:e62929. doi: 10.7554/eLife.62929. es_ES
dc.identifier.uri https://doi.org/10.7554/eLife.62929
dc.identifier.uri https://repositorio.fleni.org.ar/xmlui/handle/123456789/503
dc.description.abstract Beta-amyloid (Ab) and tau proteins, the pathological hallmarks of Alzheimer’s disease (AD), are believed to spread through connected regions of the brain. Combining diffusion imaging and positron emission tomography, we investigated associations between white matter microstructure specifically in bundles connecting regions where Ab or tau accumulates and pathology. We focused on free-water-corrected diffusion measures in the anterior cingulum, posterior cingulum, and uncinate fasciculus in cognitively normal older adults at risk of sporadic AD and presymptomatic mutation carriers of autosomal dominant AD. In Ab-positive or tau-positive groups, lower tissue fractional anisotropy and higher mean diffusivity related to greater Ab and tau burden in both cohorts. Associations were found in the posterior cingulum and uncinate fasciculus in preclinical sporadic AD, and in the anterior and posterior cingulum in presymptomatic mutation carriers. These results suggest that microstructural alterations accompany pathological accumulation as early as the preclinical stage of both sporadic and autosomal dominant AD. es_ES
dc.language.iso eng es_ES
dc.publisher eLife Sciences Publications es_ES
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by/2.5/ar/
dc.subject White Matter es_ES
dc.subject Sustancia Blanca es_ES
dc.subject Tau pathology es_ES
dc.subject Alzheimer Disease es_ES
dc.subject Enfermedad de Alzheimer es_ES
dc.subject Amyloid beta-Peptides es_ES
dc.subject Péptidos beta-Amiloides es_ES
dc.title Bundle-specific associations between white matter microstructure and Ab and tau pathology in preclinical Alzheimer’s disease es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.type info:eu-repo/semantics/publishedVersion
dc.description.fil Fil: Pichet Binette, Alexa. McGill University; Canada.
dc.description.fil Fil: Theaud, Guillaume. Université de Sherbrooke; Canada.
dc.description.fil Fil: Rheault, François. Vanderbilt University; Estados Unidos.
dc.description.fil Fil: Roy, Maggie. Université de Sherbrooke; Canadá.
dc.description.fil Fil: Collins, D. Louis. Montreal Neurological Institute; Canadá.
dc.description.fil Fil: Levin, Johannes. Ludwig-Maximilians-Universität München; Alemania.
dc.description.fil Fil: Mori, Hiroshi. Osaka City University Medical School; Japón.
dc.description.fil Fil: Lee, Hae Hong. University of Ulsan College of Medicine; Corea.
dc.description.fil Fil: Rhys Farlow, Martin.
dc.description.fil Fil: Schofield, Peter R. Neuroscience Research Australia; Australia.
dc.description.fil Fil: Chhatwal, Jasmeer P. Harvard Medical School; Estados Unidos.
dc.description.fil Fil: Masters, Colin L. University of Melbourne; Australia.
dc.description.fil Fil: Benzinger, Tammie L.S. Washington University School of Medicine; Estados Unidos.
dc.description.fil Fil: Morris, John C. Washington University School of Medicine; Estados Unidos.
dc.description.fil Fil: Bateman, Randall J. Washington University School of Medicine; Estados Unidos.
dc.description.fil Fil: Breitner, John C.S. McGill University; Canadá.
dc.description.fil Fil: Poirier, Judes. McGill University; Canadá.
dc.description.fil Fil: Allegri, Ricardo Francisco. Fleni. Departamento de Neurología. Servicio de Neurología Cognitiva, Neuropsicología y Neuropsiquiatría; Argentina.
dc.relation.ispartofCOUNTRY Reino Unido
dc.relation.ispartofCITY Cambridge
dc.relation.ispartofTITLE eLife
dc.relation.ispartofISSN 2050-084X
dc.type.snrd info:ar-repo/semantics/artículo es_ES


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