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Pattern and degree of individual brain atrophy predicts dementia onset in dominantly inherited Alzheimer's disease

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dc.contributor.author Keret, Ophir
dc.contributor.author Staffaroni, Adam M.
dc.contributor.author Ringman, John M.
dc.contributor.author Cobigo, Yann
dc.contributor.author Goh, Sheng-Yang M.
dc.contributor.author Wolf, Amy
dc.contributor.author Allen, Isabel Elaine
dc.contributor.author Salloway, Stephen
dc.contributor.author Chhatwal, Jasmeer P.
dc.contributor.author Brickman, Adam M.
dc.contributor.author Reyes-Dumeyer, Dolly
dc.contributor.author Bateman, Randall J.
dc.contributor.author Benzinger, Tammie L.S.
dc.contributor.author Morris, John C.
dc.contributor.author Ances, Beau M.
dc.contributor.author Joseph-Mathurin, Nelly
dc.contributor.author Perrin, Richard J.
dc.contributor.author Gordon, Brian A.
dc.contributor.author Allegri, Ricardo Francisco
dc.contributor.author Chrem Méndez, Patricio Alexis
dc.date.accessioned 2021-07-21T14:33:54Z
dc.date.available 2021-07-21T14:33:54Z
dc.date.issued 2021-07-05
dc.identifier.citation Keret O, Staffaroni AM, Ringman JM, Cobigo Y, Goh SM, Wolf A, Allen IE, Salloway S, Chhatwal J, Brickman AM, Reyes-Dumeyer D, Bateman RJ, Benzinger TLS, Morris JC, Ances BM, Joseph-Mathurin N, Perrin RJ, Gordon BA, Levin J, Vöglein J, Jucker M, la Fougère C, Martins RN, Sohrabi HR, Taddei K, Villemagne VL, Schofield PR, Brooks WS, Fulham M, Masters CL, Ghetti B, Saykin AJ, Jack CR, Graff-Radford NR, Weiner M, Cash DM, Allegri RF, Chrem P, Yi S, Miller BL, Rabinovici GD, Rosen HJ; Dominantly Inherited Alzheimer Network. Pattern and degree of individual brain atrophy predicts dementia onset in dominantly inherited Alzheimer's disease. Alzheimers Dement (Amst). 2021 Jul 5;13(1):e12197. doi: 10.1002/dad2.12197 es_ES
dc.identifier.uri https://doi.org/10.1002/dad2.12197
dc.identifier.uri https://repositorio.fleni.org.ar/xmlui/handle/123456789/539
dc.description.abstract Introduction Asymptomatic and mildly symptomatic dominantly inherited Alzheimer's disease mutation carriers (DIAD-MC) are ideal candidates for preventative treatment trials aimed at delaying or preventing dementia onset. Brain atrophy is an early feature of DIAD-MC and could help predict risk for dementia during trial enrollment. Methods We created a dementia risk score by entering standardized gray-matter volumes from 231 DIAD-MC into a logistic regression to classify participants with and without dementia. The score's predictive utility was assessed using Cox models and receiver operating curves on a separate group of 65 DIAD-MC followed longitudinally. Results Our risk score separated asymptomatic versus demented DIAD-MC with 96.4% (standard error = 0.02) and predicted conversion to dementia at next visit (hazard ratio = 1.32, 95% confidence interval [CI: 1.15, 1.49]) and within 2 years (area under the curve = 90.3%, 95% CI [82.3%–98.2%]) and improved prediction beyond established methods based on familial age of onset. Discussion Individualized risk scores based on brain atrophy could be useful for establishing enrollment criteria and stratifying DIAD-MC participants for prevention trials. es_ES
dc.language.iso eng es_ES
dc.publisher Wiley es_ES
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by/2.5/ar/
dc.subject Alzheimer Disease es_ES
dc.subject Enfermedad de Alzheimer es_ES
dc.subject Dementia es_ES
dc.subject Demencia es_ES
dc.title Pattern and degree of individual brain atrophy predicts dementia onset in dominantly inherited Alzheimer's disease es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.type info:eu-repo/semantics/publishedVersion
dc.description.fil Fil: Keret, Ophir. University of California; Estados Unidos.
dc.description.fil Fil: Staffaroni, Adam M. University of California; Estados Unidos.
dc.description.fil Fil: Ringman, John M. University of Southern California; Estados Unidos.
dc.description.fil Fil: Cobigo, Yann. University of California; Estados Unidos.
dc.description.fil Fil: Goh, Sheng-Yang M. University of California; Estados Unidos.
dc.description.fil Fil: Wolf, Amy. University of California; Estados Unidos.
dc.description.fil Fil: Allen, Isabel Elaine. University of California; Estados Unidos.
dc.description.fil Fil: Salloway, Stephen. Brown University; Estados Unidos.
dc.description.fil Fil: Chhatwal, Jasmeer P. Harvard Medical School; Estados Unidos.
dc.description.fil Fil: Brickman, Adam M. Columbia University; Estados Unidos.
dc.description.fil Fil: Reyes-Dumeyer, Dolly. Columbia University; Estados Unidos.
dc.description.fil Fil: Bateman, Randall J. Washington University School of Medicine; Estados Unidos.
dc.description.fil Fil: Benzinger, Tammie L.S. Washington University School of Medicine; Estados Unidos.
dc.description.fil Fil: Morris, John C. Washington University School of Medicine; Estados Unidos.
dc.description.fil Fil: Ances, Beau M. Washington University School of Medicine; Estados Unidos.
dc.description.fil Fil: Joseph-Mathurin, Nelly. Washington University School of Medicine; Estados Unidos.
dc.description.fil Fil: Perrin, Richard J. Washington University School of Medicine; Estados Unidos.
dc.description.fil Fil: Gordon, Brian A. Washington University School of Medicine; Estados Unidos.
dc.description.fil Fil: Allegri, Ricardo Francisco. Fleni. Departamento de Neurología. Servicio de Neurología Cognitiva, Neuropsicología y Neuropsiquiatría; Argentina.
dc.description.fil Fil: Chrem Méndez, Patricio. Fleni. Departamento de Neurología. Servicio de Neurología Cognitiva, Neuropsicología y Neuropsiquiatría; Argentina.
dc.relation.ispartofVOLUME 13
dc.relation.ispartofNUMBER 1
dc.relation.ispartofPAGINATION e12197
dc.relation.ispartofCOUNTRY Países Bajos
dc.relation.ispartofCITY Amsterdam
dc.relation.ispartofTITLE Alzheimer's & dementia
dc.relation.ispartofISSN 2352-8729
dc.type.snrd info:ar-repo/semantics/artículo es_ES


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