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dc.contributor.author | Marrodán, Mariano | |
dc.contributor.author | Crema, Santiago | |
dc.contributor.author | Rubstein, Adrián | |
dc.contributor.author | Alessandro, Lucas | |
dc.contributor.author | Fernández, José | |
dc.contributor.author | Correale, Jorge | |
dc.contributor.author | Ysrraelit, María Célica | |
dc.date.accessioned | 2021-08-24T17:48:41Z | |
dc.date.available | 2021-08-24T17:48:41Z | |
dc.date.issued | 2021-07-25 | |
dc.identifier.citation | 39. Marrodan M, Crema S, Rubstein A, Alessandro L, Fernandez J, Correale J, Ysrraelit MC. Therapeutic plasma exchange in MS refractory relapses: Long-term outcome. Mult Scler Relat Disord. 2021 Jul 25;55:103168. doi: 10.1016/j.msard.2021.103168 | es_ES |
dc.identifier.uri | https://doi.org/10.1016/j.msard.2021.103168 | |
dc.identifier.uri | https://repositorio.fleni.org.ar/xmlui/handle/123456789/561 | |
dc.description.abstract | Introduction Therapeutic plasma exchange (TPE) is considered a treatment option for steroid-refractory multiple sclerosis (MS) relapses. Our objective was to assess long-term clinical response to TPE in MS steroid-refractory exacerbations. Methods Retrospective study of relapsing remitting MS (RRMS) patients presenting intravenous methylprednisolone (IVMPS)-refractory relapses, who underwent TPE. Response to TPE was assessed at 1, 3, 6, 12 and 24-months post-treatment, and compared to a second group of RRMS patients with similar demographic and clinical characteristics presenting, IVMPS-refractory relapses but not treated with TPE. Multivariate regression analysis was used to assess potential predictors of significant clinical response. Results Between 2011 to 2020, a total of 23 RRMS patients were treated with TPE. Twenty-one patients not receiving the treatment served as controls. No differences in demographic or clinical characteristics, or predictors of clinical improvement after TPE were detected between groups. Seventy-eight percent of patients treated with TPE presented clinical improvement at 24 months. TPE-treated patients presented lower EDSS scores at 6 and at 24 months. Younger age, presence of gadolinium-enhancing lesions and TPE treatment were associated with better clinical outcomes. No life-threatening side effects were reported. Conclusions TPE is a safe and well tolerated procedure that decreases long-term disability in RRMS patients with IVMPS-refractory relapses. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by/2.5/ar/ | |
dc.subject | Multiple Sclerosis, Relapsing-Remitting | es_ES |
dc.subject | Esclerosis Múltiple Recurrente-Remitente | es_ES |
dc.subject | Plasma Exchange | es_ES |
dc.subject | Intercambio Plasmático | es_ES |
dc.title | Therapeutic plasma exchange in MS refractory relapses: Long-term outcome | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.type | info:eu-repo/semantics/publishedVersion | |
dc.description.fil | Fil: Marrodán, Mariano. Fleni. Departamento de Neurología; Argentina. | |
dc.description.fil | Fil: Crema, Santiago. Fleni. Departamento de Neurología; Argentina | |
dc.description.fil | Fil: Rubstein, A. Merck KGaA; Alemania. | |
dc.description.fil | Fil: Alessandro, Lucas. Fleni. Departamento de Neurología; Argentina. | |
dc.description.fil | Fil: Fernández, José. Fleni. Departamento de Medicina Interna. Hematología y Trombosis; Argentina. | |
dc.description.fil | Fil: Correale, Jorge. Fleni. Departamento de Neurología. Servicio de Neuroinmunología y Enfermedades Desmielinizantes; Argentina | |
dc.description.fil | Fil: Ysrraelit, Maria Célica. Fleni. Departamento de Neurología; Argentina. | |
dc.relation.ispartofCOUNTRY | Países Bajos | |
dc.relation.ispartofCITY | Amsterdam | |
dc.relation.ispartofTITLE | Multiple sclerosis and related disorders | |
dc.relation.ispartofISSN | 2211-0356 | |
dc.type.snrd | info:ar-repo/semantics/artículo | es_ES |