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dc.contributor.advisor
dc.contributor.author Correale, Jorge
dc.contributor.author Gaitán, María Inés
dc.date.accessioned 2019-10-16T18:34:01Z
dc.date.available 2019-10-16T18:34:01Z
dc.date.issued 2019-08-14
dc.identifier.citation Correale J, Gaitán MI. Autoimmune Astrocytopathy. In: Mitoma H, Manto M, eds. Neuroimmune Diseases: From Cells to the Living Brain. Contemporary Clinical Neuroscience. Cham: Springer International Publishing; 2019:329-355. doi:10.1007/978-3-030-19515-1_10 en_US
dc.identifier.uri https://repositorio.fleni.org.ar/handle/123456789/58
dc.identifier.uri https://doi.org/10.1007/978-3-030-19515-1_10
dc.description.abstract Astrocytes are the most abundant and heterogeneous type of glial cell in the Central Nervous System. In addition to their role maintaining physiological conditions stable in the CNS, they are recognized as early and highly active players in immune responses in the CNS, and their dysfunction is believed to contribute to neuroimmune disease. Perhaps one of the most important discoveries in recent years has been the identification of IgG-NMO, a specific pathogenic antibody directed against water channel aquaporin-4 (AQP4). IgG-NMO has not only made neuromyelitis optica diagnosis easier but has allowed differential diagnoses to be established more clearly and lead to the design of better therapeutic alternatives. Likewise, a novel autoantibody directed against GFAP has been identified as biomarker of a relapsing autoimmune form of meningoencephalomyelitis, responsive to steroids, often associated with tumors. Similarly, in Rasmussen’s encephalitis, CD8+ T lymphocytes cause astrocyte apoptosis and loss in affected areas, altering normal neuron function. Reactive astrocytes also play an important role in different CNS infections, not only during acute phases of disease but also long term, and may condition the development of post-infectious sequelae. Finally, multiple mechanisms mediated by astrocytes are known to participate in both the genesis and the progression of MS and in processes of remyelination. Overall, these observations indicate astrocytes actively participate in both pathological and in repair mechanisms, observed in CNS neuroimmune diseases. en_US
dc.language.iso eng en_US
dc.publisher Springer en_US
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by/2.5/ar/
dc.subject Multiple Sclerosis en_US
dc.subject Esclerosis Múltiple en_US
dc.subject Neuromyelitis Optica en_US
dc.subject Neuromielitis Óptica en_US
dc.subject Encephalitis en_US
dc.subject Encefalitis en_US
dc.subject Astrocytes en_US
dc.subject Astrocitos en_US
dc.title Autoimmune Astrocytopathy en_US
dc.type info:eu-repo/semantics/publishedVersion
dc.type info:eu-repo/semantics/bookPart en_US
dc.description.fil Fil: Correale, Jorge. Fleni. Departamento de Neurología. Servicio de Neuroinmunología y Enfermedades Desmielinizantes; Argentina.
dc.description.fil Fil: Gaitán, María Inés. Fleni. Departamento de Neurología. Servicio de Neuroinmunología y Enfermedades Desmielinizantes; Argentina.
dc.relation.ispartofPAGINATION 329-355
dc.relation.ispartofCOUNTRY Alemania
dc.relation.ispartofCITY Berlín
dc.relation.ispartofTITLE Neuroimmune Diseases: From Cells to the Living Brain
dc.relation.ispartofISBN 978-3-030-19515-1
dc.type.snrd info:ar-repo/semantics/artículo es_ES


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