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dc.contributor.author | Correale, Jorge | |
dc.contributor.author | Marrodán, Mariano | |
dc.contributor.author | Carnero Contentti, Edgar | |
dc.date.accessioned | 2021-10-07T17:17:06Z | |
dc.date.available | 2021-10-07T17:17:06Z | |
dc.date.issued | 2021-07-01 | |
dc.identifier.citation | Correale J, Marrodan M, Carnero Contentti E. Interleukin-35 is a critical regulator of immunity during helminth infections associated with multiple sclerosis. Immunology. 2021 Jul 1. doi: 10.1111/imm.13389 | es_ES |
dc.identifier.uri | https://doi.org/10.1111/imm.13389 | |
dc.identifier.uri | https://repositorio.fleni.org.ar/xmlui/handle/123456789/601 | |
dc.description.abstract | Multiple sclerosis (MS) is currently thought to arise by interactions between genetic susceptibility and environmental factors. Infections in general trigger autoimmune responses causing clinical manifestations of disease. However, as a result of regulatory T (Treg)- and regulatory B (Breg)-cell induction, helminth infections tend to dampen disease activity. IL-35, the newest member of the IL-12 family, is an inhibitory cytokine composed of an EBI3β chain subunit, and an IL-12p35 subunit. The aim of this study was to investigate the role of IL-35 during parasite infections occurring in individuals with MS. Numbers of IL-35-producing Breg cells are higher in CSF from helminth-infected than from uninfected MS subjects, a finding associated with decreased MRI disease activity. Interestingly, stimulation of CD19+ B cells with IL-35 promotes conversion of these cells to Breg cells producing both IL-35 and IL-10. Coculture of B cells from helminth-infected MS patients inhibits proliferation of Th1 and Th17 myelin peptide-specific T cells, as well as production of IFN-γ and IL-17. Following activation, CD4+ CD25+ Treg cells significantly upregulate expression of EBI3 and IL-12p35 mRNA. Furthermore, CD4+ CD25- T cells activated in the presence of IL-35 induce a population of cells with regulatory function, known as iTR35. Finally, B cells from normal individuals cultured in vitro in the presence of the helminth antigen SEA increase expression of the transcription BATF, IRF4 and IRF8, acquiring a pattern similar to that of IL-35 Breg cells. These data highlight the important immunoregulatory effects of IL-35 on both Breg and Treg cells, observed in helminth-infected MS subjects. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Wiley | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by/2.5/ar/ | |
dc.subject | Multiple Sclerosis | es_ES |
dc.subject | Esclerosis Múltiple | es_ES |
dc.subject | Interleukin-35 | es_ES |
dc.subject | Interleuquina-35 | es_ES |
dc.subject | Helminths | es_ES |
dc.subject | Helmintos | es_ES |
dc.title | Interleukin-35 is a critical regulator of immunity during helminth infections associated with multiple sclerosis | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.type | info:eu-repo/semantics/publishedVersion | |
dc.description.fil | Fil: Correale, Jorge. Fleni. Departamento de Neurología. Servicio de Neuroinmunología y Enfermedades Desmielinizantes; Argentina | |
dc.description.fil | Fil: Marrodan, Mariano. Fleni. Departamento de Neurología. Servicio de Neuroinmunología y Enfermedades Desmielinizantes; Argentina | |
dc.description.fil | Fil: Carnero Contentti, Edgar. Hospital Alemán; Argentina. | |
dc.relation.ispartofCOUNTRY | Reino Unido | |
dc.relation.ispartofCITY | Oxford | |
dc.relation.ispartofTITLE | Immunology | |
dc.relation.ispartofISSN | 1365-2567 | |
dc.type.snrd | info:ar-repo/semantics/artículo | es_ES |