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Clinical and demographic characteristics of male MS patients included in the national registry-RelevarEM. Does sex or phenotype make the difference in the association with poor prognosis?

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dc.contributor.author Luetic, Geraldine G.
dc.contributor.author Menichini, María Laura
dc.contributor.author Vrech, Carlos
dc.contributor.author Pappolla, Agustín
dc.contributor.author Patrucco, Liliana
dc.contributor.author Cristiano, Edgardo
dc.contributor.author Marrodán, Mariano
dc.contributor.author Ysrraelit, María Célica
dc.contributor.author Fiol, Marcela Paula
dc.contributor.author Correale, Jorge
dc.contributor.author Cohen, Leila
dc.contributor.author Alonso, Ricardo
dc.contributor.author Silva, Berenice Anabel
dc.contributor.author Casas, Magdalena
dc.contributor.author Garcea, Orlando
dc.contributor.author Deri, Norma
dc.contributor.author Burgos, Marcos
dc.contributor.author Liwacki, Susana
dc.contributor.author Tkachuk, Verónica A.
dc.contributor.author Barboza, Andrés G.
dc.date.accessioned 2022-07-12T15:48:52Z
dc.date.available 2022-07-12T15:48:52Z
dc.date.issued 2021-11-17
dc.identifier.citation 57. Luetic GG, Menichini ML, Vrech C, Pappolla A, Patrucco L, Cristiano E, Marrodán M, Ysrraelit MC, Fiol M, Correale J, Cohen L, Alonso R, Silva B, Casas M, Garcea O, Deri N, Burgos M, Liwacki S, Tkachuk V, Barboza A, Piedrabuena R, Blaya P, Steinberg J, Martínez A, Carrá A, Tavolini D, López P, Knorre E, Nofal P, Volman G, Carnero Contentti E, Pinheiro AA, Leguizamon F, Silva E, Hryb J, Balbuena ME, Zanga G, Kohler M, Chertcoff A, Lazaro L, Tizio S, Mainela C, Reich E, Recchia L, Blanche J, Marcilla MP, Fracaro ME, Sgrilli G, Divi P, Jacobo M, Cabrera M, Pagani Cassara F, Sinay V, Curbelo C, Míguez J, Coppola M, Liguori NF, Martos I, Pettinicchi JP, Viglione JP, José G, Bestoso S, Manzi R, Vázquez G, Nadur D, Martínez C, Serena MA, Rojas JI. Clinical and demographic characteristics of male MS patients included in the national registry-RelevarEM. Does sex or phenotype make the difference in the association with poor prognosis? Mult Scler Relat Disord. 2022 Feb;58:103401. doi: 10.1016/j.msard.2021.103401. Epub 2021 Nov 17 es_ES
dc.identifier.uri https://doi.org/10.1016/j.msard.2021.103401
dc.identifier.uri https://repositorio.fleni.org.ar/xmlui/handle/123456789/625
dc.description.abstract Background In multiple sclerosis demographics there is a well-known female prevalence and male patients have been less specifically evaluated in clinical studies, though some clinical differences have been reported between sexes. Objective The objective of this study was to assess clinical and demographic differences between male and female patients included in the national Argentine MS Registry-RelevarEM. Material and methods This study was observational, retrospective, and was based on the data of 3099 MS patients included as of 04 April 2021. The statistical analysis plan included bivariate analyses with the crude data and also after adjustment for the MS phenotype, further categorized as progressive-onset MS or relapsing-onset MS. In the adjusted analysis, the Mantel-Haenszel odds ratio was compared to the crude odds ratio, to account for the phenotype as a confounder. Results The data from 1,074 (34.7%) men and 2,025 (65.3%) women with MS diagnosis were analysed. Males presented primary progressive disease two times more often than women (11% and 5%, respectively). In the crude analyses by sex, the presence of exclusively infratentorial lesions in the magnetic resonance imaging studies was more frequent in males than in females, but after adjustment by MS onset phenotype, such difference was only present in males with relapsing-onset MS (p = 0.00006). Similarly, worse Expanded Disability Status Scale scores were confirmed only in men with relapsing-onset disease after phenotype adjustment (p = 0.02). Conclusion We did not find any statistically significant clinical or demographic difference between sexes when the progressive MS phenotype was specifically considered. However, the differences we found between the clinical phenotypes are in line with the literature and highlight the importance of stratifying the analyses by sex and phenotype when designing MS studies. es_ES
dc.language.iso eng es_ES
dc.publisher Elsevier es_ES
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by/2.5/ar/
dc.subject Esclerosis Múltiple es_ES
dc.subject Multiple Sclerosis es_ES
dc.subject Demografía es_ES
dc.subject Demography es_ES
dc.subject Progresión de la Enfermedad es_ES
dc.subject Disease Progression es_ES
dc.title Clinical and demographic characteristics of male MS patients included in the national registry-RelevarEM. Does sex or phenotype make the difference in the association with poor prognosis? es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.type info:eu-repo/semantics/publishedVersion
dc.description.fil Fil: Luetic, Geraldine G. Instituto de Neurociencias de Rosario; Argentina.
dc.description.fil Fil: Menichini, María Laura. Instituto de Neurociencias de Rosario; Argentina.
dc.description.fil Fil: Vrech, Carlos. Sanatorio Allende; Argentina.
dc.description.fil Fil: Pappolla, Agustín. Hospital Italiano de Buenos Aires; Argentina.
dc.description.fil Fil: Patrucco, Liliana. Centro de esclerosis múltiple de Buenos Aires; Argentina.
dc.description.fil Fil: Cristiano, Edgardo. Centro de esclerosis múltiple de Buenos Aires; Argentina.
dc.description.fil Fil: Marrodán, Mariano. Fleni. Departamento de Neurología. Servicio de Neuroinmunología y Enfermedades Desmielinizantes; Argentina.
dc.description.fil Fil: Ysrraelit, María Célica. Fleni. Departamento de Neurología. Servicio de Neuroinmunología y Enfermedades Desmielinizantes; Argentina.
dc.description.fil Fil: Fiol, Marcela Paula. Fleni. Departamento de Neurología. Servicio de Neuroinmunología y Enfermedades Desmielinizantes; Argentina.
dc.description.fil Fil: Correale, Jorge. Fleni. Departamento de Neurología. Servicio de Neuroinmunología y Enfermedades Desmielinizantes; Argentina.
dc.description.fil Fil: Cohen, Leila. Hospital Ramos Mejía; Argentina.
dc.description.fil Fil: Alonso, Ricardo. Hospital Ramos Mejía; Argentina.
dc.description.fil Fil: Silva, Berenice Anabel. Hospital Ramos Mejía; Argentina.
dc.description.fil Fil: Casas, Magdalena. Hospital Ramos Mejía; Argentina.
dc.description.fil Fil: Garcea, Orlando. Hospital Ramos Mejía; Argentina.
dc.description.fil Fil: Deri, Norma. Centro de Investigaciones Diabaid; Argentina.
dc.description.fil Fil: Burgos, Marcos. Hospital San Bernardo;Argentina.
dc.description.fil Fil: Liwacki, Susana. Clínica Universitaria Reina Fabiola; Argentina.
dc.description.fil Fil: Tkachuk, Verónica A. Hospital de Clínicas José de San Martín; Argentina.
dc.description.fil Fil: Barboza, Andrés G. Hospital Central de Mendoza; Argentina.
dc.relation.ispartofVOLUME 58
dc.relation.ispartofPAGINATION 103401
dc.relation.ispartofCOUNTRY Países Bajos
dc.relation.ispartofCITY Amsterdam
dc.relation.ispartofTITLE Multiple sclerosis and related disorders
dc.relation.ispartofISSN 2211-0356
dc.type.snrd info:ar-repo/semantics/artículo es_ES


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