dc.contributor.author |
Buckles, Virginia |
|
dc.contributor.author |
Xiong, Chengjie |
|
dc.contributor.author |
Bateman, Randall J. |
|
dc.contributor.author |
Hassenstab, Jason |
|
dc.contributor.author |
Allegri, Ricardo Francisco |
|
dc.contributor.author |
Berman, Sarah B. |
|
dc.contributor.author |
Chhatwal, Jasmeer P. |
|
dc.contributor.author |
Danek, Adrian |
|
dc.contributor.author |
Fagan, Anne M. |
|
dc.contributor.author |
Ghetti, Bernardino |
|
dc.contributor.author |
Goate, Alison M. |
|
dc.contributor.author |
Graff-Radford, Neill R. |
|
dc.contributor.author |
Jucker, Mathias |
|
dc.contributor.author |
Levin, Johannes |
|
dc.contributor.author |
Marcus, Daniel S. |
|
dc.contributor.author |
Masters, Colin L. |
|
dc.contributor.author |
McCue, Lena M. |
|
dc.contributor.author |
McDade, Eric |
|
dc.contributor.author |
Mori, Hiroshi |
|
dc.contributor.author |
Moulder, Krista L. |
|
dc.date.accessioned |
2022-07-18T14:37:21Z |
|
dc.date.available |
2022-07-18T14:37:21Z |
|
dc.date.issued |
2021-12-02 |
|
dc.identifier.citation |
Buckles V, Xiong C, Bateman RJ, Hassenstab J, Allegri R, Berman SB, Chhatwal JP, Danek A, Fagan AM, Ghetti B, Goate AM, Graff-Radford NR, Jucker M, Levin J, Marcus DS, Masters CL, McCue LM, McDade E, Mori H, Moulder KL, Noble JM, Paumier K, Preische O, Ringman JM, Fox NC, Salloway S, Schofield PR, Martins R, Vöglein J, Morris JC; Dominantly Inherited Alzheimer's Network. Different rates of cognitive decline in autosomal dominant and late-onset Alzheimer disease. Alzheimers Dement. 2021 Dec 2. doi: 10.1002/alz.12505 |
es_ES |
dc.identifier.uri |
https://doi.org/10.1002/alz.12505 |
|
dc.identifier.uri |
https://repositorio.fleni.org.ar/xmlui/handle/123456789/630 |
|
dc.description.abstract |
As prevention trials advance with autosomal dominant Alzheimer disease (ADAD) participants, understanding the similarities and differences between ADAD and "sporadic" late-onset AD (LOAD) is critical to determine generalizability of findings between these cohorts. Cognitive trajectories of ADAD mutation carriers (MCs) and autopsy-confirmed LOAD individuals were compared to address this question. Longitudinal rates of change on cognitive measures were compared in ADAD MCs (n = 310) and autopsy-confirmed LOAD participants (n = 163) before and after symptom onset (estimated/observed). LOAD participants declined more rapidly in the presymptomatic (preclinical) period and performed more poorly at symptom onset than ADAD participants on a cognitive composite. After symptom onset, however, the younger ADAD MCs declined more rapidly. The similar but not identical cognitive trajectories (declining but at different rates) for ADAD and LOAD suggest common AD pathologies but with some differences. |
es_ES |
dc.language.iso |
eng |
es_ES |
dc.publisher |
John Wiley & Sons |
es_ES |
dc.rights |
info:eu-repo/semantics/openAccess |
|
dc.rights.uri |
https://creativecommons.org/licenses/by/2.5/ar/ |
|
dc.subject |
Alzheimer Disease |
es_ES |
dc.subject |
Enfermedad de Alzheimer |
es_ES |
dc.subject |
Cognitive Dysfunction |
es_ES |
dc.subject |
Disfunción Cognitiva |
es_ES |
dc.title |
Different rates of cognitive decline in autosomal dominant and late-onset Alzheimer disease |
es_ES |
dc.type |
info:eu-repo/semantics/article |
es_ES |
dc.type |
info:eu-repo/semantics/publishedVersion |
|
dc.description.fil |
Fil: Buckles, Virginia. Washington University School of Medicine; Estados Unidos. |
|
dc.description.fil |
Fil: Xiong, Chengjie. Washington University School of Medicine; Estados Unidos. |
|
dc.description.fil |
Fil: Bateman, Randall J. Washington University School of Medicine; Estados Unidos. |
|
dc.description.fil |
Fil: Hassenstab, Jason. Washington University School of Medicine; Estados Unidos. |
|
dc.description.fil |
Fil: Allegri, Ricardo Francisco. Fleni. Departamento de Neurología. Servicio de Neurología Cognitiva, Neuropsicología y Neuropsiquiatría; Argentina. |
|
dc.description.fil |
Fil: Berman, Sarah B. University of Pittsburgh; Estados Unidos. |
|
dc.description.fil |
Fil: Chhatwal, Jasmeer P. Massachusetts General Hospital; Estados Unidos. |
|
dc.description.fil |
Fil: Danek, Adrian. Klinikum der Universität München; Alemania. |
|
dc.description.fil |
Fil: Fagan, Anne M. Washington University School of Medicine; Estados Unidos. |
|
dc.description.fil |
Fil: Ghetti, Bernardino. Indiana University School of Medicine; Estados Unidos. |
|
dc.description.fil |
Fil: Goate, Alison M. Icahn School of Medicine at Mount Sinai; Estados Unidos. |
|
dc.description.fil |
Fil: Graff-Radford, Neill R. Mayo Clinic; Estados Unidos. |
|
dc.description.fil |
Fil: Jucker, Mathias. University of Tuebingen; Alemania. |
|
dc.description.fil |
Fil: Levin, Johannes. Munich Cluster of Systems Neurology; Alemania. |
|
dc.description.fil |
Fil: Marcus, Daniel S. Washington University School of Medicine; Estados Unidos. |
|
dc.description.fil |
Fil: Masters, Colin L. University of Melbourne; Australia. |
|
dc.description.fil |
Fil: McCue, Lena M. Washington University School of Medicine; Estados Unidos. |
|
dc.description.fil |
Fil: McDade, Eric. Washington University School of Medicine; Estados Unidos. |
|
dc.description.fil |
Fil: Mori, Hiroshi. Osaka City University Medical School; Japón. |
|
dc.description.fil |
Fil: Moulder, Krista L. Washington University School of Medicine; Estados Unidos. |
|
dc.relation.ispartofCOUNTRY |
Estados Unidos |
|
dc.relation.ispartofCITY |
Hoboken |
|
dc.relation.ispartofTITLE |
Alzheimer's & dementia |
|
dc.relation.ispartofISSN |
1552-5279 |
|
dc.type.snrd |
info:ar-repo/semantics/artículo |
es_ES |