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Different rates of cognitive decline in autosomal dominant and late-onset Alzheimer disease

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dc.contributor.author Buckles, Virginia
dc.contributor.author Xiong, Chengjie
dc.contributor.author Bateman, Randall J.
dc.contributor.author Hassenstab, Jason
dc.contributor.author Allegri, Ricardo Francisco
dc.contributor.author Berman, Sarah B.
dc.contributor.author Chhatwal, Jasmeer P.
dc.contributor.author Danek, Adrian
dc.contributor.author Fagan, Anne M.
dc.contributor.author Ghetti, Bernardino
dc.contributor.author Goate, Alison M.
dc.contributor.author Graff-Radford, Neill R.
dc.contributor.author Jucker, Mathias
dc.contributor.author Levin, Johannes
dc.contributor.author Marcus, Daniel S.
dc.contributor.author Masters, Colin L.
dc.contributor.author McCue, Lena M.
dc.contributor.author McDade, Eric
dc.contributor.author Mori, Hiroshi
dc.contributor.author Moulder, Krista L.
dc.date.accessioned 2022-07-18T14:37:21Z
dc.date.available 2022-07-18T14:37:21Z
dc.date.issued 2021-12-02
dc.identifier.citation Buckles V, Xiong C, Bateman RJ, Hassenstab J, Allegri R, Berman SB, Chhatwal JP, Danek A, Fagan AM, Ghetti B, Goate AM, Graff-Radford NR, Jucker M, Levin J, Marcus DS, Masters CL, McCue LM, McDade E, Mori H, Moulder KL, Noble JM, Paumier K, Preische O, Ringman JM, Fox NC, Salloway S, Schofield PR, Martins R, Vöglein J, Morris JC; Dominantly Inherited Alzheimer's Network. Different rates of cognitive decline in autosomal dominant and late-onset Alzheimer disease. Alzheimers Dement. 2021 Dec 2. doi: 10.1002/alz.12505 es_ES
dc.identifier.uri https://doi.org/10.1002/alz.12505
dc.identifier.uri https://repositorio.fleni.org.ar/xmlui/handle/123456789/630
dc.description.abstract As prevention trials advance with autosomal dominant Alzheimer disease (ADAD) participants, understanding the similarities and differences between ADAD and "sporadic" late-onset AD (LOAD) is critical to determine generalizability of findings between these cohorts. Cognitive trajectories of ADAD mutation carriers (MCs) and autopsy-confirmed LOAD individuals were compared to address this question. Longitudinal rates of change on cognitive measures were compared in ADAD MCs (n = 310) and autopsy-confirmed LOAD participants (n = 163) before and after symptom onset (estimated/observed). LOAD participants declined more rapidly in the presymptomatic (preclinical) period and performed more poorly at symptom onset than ADAD participants on a cognitive composite. After symptom onset, however, the younger ADAD MCs declined more rapidly. The similar but not identical cognitive trajectories (declining but at different rates) for ADAD and LOAD suggest common AD pathologies but with some differences. es_ES
dc.language.iso eng es_ES
dc.publisher John Wiley & Sons es_ES
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by/2.5/ar/
dc.subject Alzheimer Disease es_ES
dc.subject Enfermedad de Alzheimer es_ES
dc.subject Cognitive Dysfunction es_ES
dc.subject Disfunción Cognitiva es_ES
dc.title Different rates of cognitive decline in autosomal dominant and late-onset Alzheimer disease es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.type info:eu-repo/semantics/publishedVersion
dc.description.fil Fil: Buckles, Virginia. Washington University School of Medicine; Estados Unidos.
dc.description.fil Fil: Xiong, Chengjie. Washington University School of Medicine; Estados Unidos.
dc.description.fil Fil: Bateman, Randall J. Washington University School of Medicine; Estados Unidos.
dc.description.fil Fil: Hassenstab, Jason. Washington University School of Medicine; Estados Unidos.
dc.description.fil Fil: Allegri, Ricardo Francisco. Fleni. Departamento de Neurología. Servicio de Neurología Cognitiva, Neuropsicología y Neuropsiquiatría; Argentina.
dc.description.fil Fil: Berman, Sarah B. University of Pittsburgh; Estados Unidos.
dc.description.fil Fil: Chhatwal, Jasmeer P. Massachusetts General Hospital; Estados Unidos.
dc.description.fil Fil: Danek, Adrian. Klinikum der Universität München; Alemania.
dc.description.fil Fil: Fagan, Anne M. Washington University School of Medicine; Estados Unidos.
dc.description.fil Fil: Ghetti, Bernardino. Indiana University School of Medicine; Estados Unidos.
dc.description.fil Fil: Goate, Alison M. Icahn School of Medicine at Mount Sinai; Estados Unidos.
dc.description.fil Fil: Graff-Radford, Neill R. Mayo Clinic; Estados Unidos.
dc.description.fil Fil: Jucker, Mathias. University of Tuebingen; Alemania.
dc.description.fil Fil: Levin, Johannes. Munich Cluster of Systems Neurology; Alemania.
dc.description.fil Fil: Marcus, Daniel S. Washington University School of Medicine; Estados Unidos.
dc.description.fil Fil: Masters, Colin L. University of Melbourne; Australia.
dc.description.fil Fil: McCue, Lena M. Washington University School of Medicine; Estados Unidos.
dc.description.fil Fil: McDade, Eric. Washington University School of Medicine; Estados Unidos.
dc.description.fil Fil: Mori, Hiroshi. Osaka City University Medical School; Japón.
dc.description.fil Fil: Moulder, Krista L. Washington University School of Medicine; Estados Unidos.
dc.relation.ispartofCOUNTRY Estados Unidos
dc.relation.ispartofCITY Hoboken
dc.relation.ispartofTITLE Alzheimer's & dementia
dc.relation.ispartofISSN 1552-5279
dc.type.snrd info:ar-repo/semantics/artículo es_ES


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