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Seasonal variation in attacks of neuromyelitis optica spectrum disorders and multiple sclerosis: Evaluation of 794 attacks from a nationwide registry in Argentina

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dc.contributor.author Carnero Contentti, Edgar
dc.contributor.author López, Pablo Adrián
dc.contributor.author Pettinicchi, Juan Pablo
dc.contributor.author Criniti, Juan
dc.contributor.author Pappolla, Agustín
dc.contributor.author Miguez, Jimena
dc.contributor.author Patrucco, Liliana
dc.contributor.author Cristiano, Edgardo
dc.contributor.author Liwacki, Susana
dc.contributor.author Tkachuk, Verónica A.
dc.contributor.author Balbuena Aguirre, María Eugenia
dc.contributor.author Vrech, Carlos
dc.contributor.author Deri, Norma
dc.contributor.author Correale, Jorge
dc.contributor.author Marrodán, Mariano
dc.contributor.author Ysrraelit, María Célica
dc.contributor.author Leguizamon, Felisa
dc.contributor.author Luetic, Geraldine G.
dc.contributor.author Menichini, María Laura
dc.contributor.author Tavolini, Darío
dc.date.accessioned 2022-07-19T17:46:29Z
dc.date.available 2022-07-19T17:46:29Z
dc.date.issued 2021-12-13
dc.identifier.citation Carnero Contentti E, Lopez PA, Pettinicchi JP, Criniti J, Pappolla A, Miguez J, Patrucco L, Cristiano E, Liwacki S, Tkachuk V, Balbuena ME, Vrech C, Deri N, Correale J, Marrodan M, Ysrraelit MC, Leguizamon F, Luetic GG, Menichini ML, Tavolini D, Mainella C, Zanga G, Burgos M, Hryb J, Barboza A, Lazaro L, Alonso R, Fernández Liguori N, Nadur D, Chercoff A, Alonso Serena M, Caride A, Paul F, Rojas JI. Seasonal variation in attacks of neuromyelitis optica spectrum disorders and multiple sclerosis: Evaluation of 794 attacks from a nationwide registry in Argentina. Mult Scler Relat Disord. 2021 Dec 13;58:103466 es_ES
dc.identifier.uri https://doi.org/10.1016/j.msard.2021.103466
dc.identifier.uri https://repositorio.fleni.org.ar/xmlui/handle/123456789/633
dc.description.abstract Background: Identification of triggers that potentially instigate attacks in neuromyelitis optica spectrum disorders (NMOSD) and multiple sclerosis (MS) has remained challenging. We aimed to analyze the seasonality of NMOSD and MS attacks in an Argentinean cohort seeking differences between the two disorders. Methods: A retrospective study was conducted in a cohort of NMOSD and MS patients followed in specialized centers from Argentina and enrolled in RelevarEM, a nationwide, longitudinal, observational, non-mandatory registry of MS/NMOSD patients. Patients with complete relapse data (date, month and year) at onset and during follow-up were included. Attack counts were analyzed by month using a Poisson regression model with the median monthly attack count used as reference. Results: A total of 551 patients (431 MS and 120 NMOSD), experiencing 236 NMOSD-related attacks and 558 MS-related attacks were enrolled. The mean age at disease onset in NMOSD was 39.5 ± 5.8 vs. 31.2 ± 9.6 years in MS (p < 0.01). Mean follow-up time was 6.1 ± 3.0 vs. 7.4 ± 2.4 years (p < 0.01), respectively. Most of the included patients were female in both groups (79% vs. 60%, p < 0.01). We found a peak of number of attacks in June (NMOSD: 28 attacks (11.8%) vs MS: 33 attacks (5.9%), incidence rate ratio 1.82, 95%CI 1.15-2.12, p = 0.03), but no differences were found across the months in both disorders when evaluated separately. Strikingly, we observed a significant difference in the incidence rate ratio of attacks during the winter season when comparing NMOSD vs. MS (NMOSD: 75 attacks (31.7%) vs MS: 96 attacks (17.2%), incidence rate ratio 1.82, 95%CI 1.21-2.01, p = 0.02) after applying Poisson regression model. Similar results were observed when comparing the seropositive NMOSD (n = 75) subgroup vs. MS. Conclusions: Lack of seasonal variation in MS and NMOSD attacks was observed when evaluated separately. Future epidemiological studies about the effect of different environmental factors on MS and NMOSD attacks should be evaluated prospectively in Latin America population. es_ES
dc.language.iso eng es_ES
dc.publisher Elsevier es_ES
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by/2.5/ar/
dc.subject Esclerosis Múltiple es_ES
dc.subject Multiple Sclerosis es_ES
dc.subject Neuromielitis Óptica es_ES
dc.subject Neuromyelitis Optica es_ES
dc.title Seasonal variation in attacks of neuromyelitis optica spectrum disorders and multiple sclerosis: Evaluation of 794 attacks from a nationwide registry in Argentina es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.type info:eu-repo/semantics/publishedVersion
dc.description.fil Fil: Carnero Contentti, Edgar. Hospital Alemán. Departamento de Neurociencias. Unidad de Neuroinmunología; Argentina.
dc.description.fil Fil: López, Pablo Adrián. Hospital Alemán. Departamento de Neurociencias. Unidad de Neuroinmunología; Argentina.
dc.description.fil Fil: Pettinicchi, Juan Pablo. Hospital Alemán. Departamento de Neurociencias. Unidad de Neuroinmunología; Argentina.
dc.description.fil Fil: Criniti, Juan. Hospital Alemán. Departamento de Neurociencias. Unidad de Neuroinmunología; Argentina.
dc.description.fil Fil: Pappolla, Agustín. Hospital Italiano de Buenos Aires. Servicio de Neurología; Argentina.
dc.description.fil Fil: Miguez, Jimena. Hospital Italiano de Buenos Aires. Servicio de Neurología; Argentina.
dc.description.fil Fil: Patrucco, Liliana. Hospital Italiano de Buenos Aires. Servicio de Neurología; Argentina.
dc.description.fil Fil: Cristiano, Edgardo. Centro de esclerosis múltiple de Buenos Aires; Argentina.
dc.description.fil Fil: Liwacki, Susana. Clínica Universitaria Reina Fabiola. Servicio de Neurología; Argentina.
dc.description.fil Fil: Tkachuk, Verónica A. Hospital de Clínicas José de San Martín. Servicio de Neurología. Sección de Neuroinmunología y Enfermedades Desmielinizantes; Argentina.
dc.description.fil Fil: Balbuena Aguirre, María Eugenia. Hospital de Clínicas José de San Martín; Argentina.
dc.description.fil Fil: Vrech, Carlos. Sanatorio Allende. Departamento de Enfermedades Desmielinizantes; Argentina.
dc.description.fil Fil: Deri, Norma. Centro de Investigaciones Diabaid; Argentina.
dc.description.fil Fil: Correale, Jorge. Fleni. Departamento de Neurología. Servicio de Neuroinmunología y Enfermedades Desmielinizantes; Argentina.
dc.description.fil Fil: Marrodán, Mariano. Fleni. Departamento de Neurología. Servicio de Neuroinmunología y Enfermedades Desmielinizantes; Argentina.
dc.description.fil Fil: Ysrraelit, María Célica. Fleni. Departamento de Neurología. Servicio de Neuroinmunología y Enfermedades Desmielinizantes; Argentina.
dc.description.fil Fil: Leguizamon, Felisa. Hospital de Agudos Dr. Teodoro Álvarez; Argentina.
dc.description.fil Fil: Luetic, Geraldine G. Hospital de Agudos Dr. Teodoro Álvarez; Argentina.
dc.description.fil Fil: Menichini, María Laura. Sanatorio Británico; Argentina.
dc.description.fil Fil: Tavolini, Darío. INECO; Argentina.
dc.relation.ispartofVOLUME 58
dc.relation.ispartofCOUNTRY Países Bajos
dc.relation.ispartofCITY Amsterdam
dc.relation.ispartofTITLE Multiple sclerosis and related disorders
dc.relation.ispartofISSN 2211-0356
dc.type.snrd info:ar-repo/semantics/artículo es_ES


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