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Rebound activity after fingolimod cessation: A case - control study

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dc.contributor.author Barboza, Andrés G.
dc.contributor.author Gaitán, María Inés
dc.contributor.author Alonso, Ricardo
dc.contributor.author Ysrraelit, María Célica
dc.contributor.author Luetic, Geraldine G.
dc.contributor.author Liwacki, Susana
dc.contributor.author Patrucco, Liliana
dc.contributor.author Halfon, Mario Javier
dc.contributor.author Burgos, Marcos
dc.contributor.author Mainella, Carolina
dc.contributor.author Piedrabuena, Raúl
dc.contributor.author Recchia, Luciano
dc.contributor.author Steinberg, Judith
dc.contributor.author Tkachuk, Verónica A.
dc.contributor.author Zanga, Gisela
dc.contributor.author Carra, Adriana
dc.contributor.author Chertcoff, Aníbal
dc.contributor.author Fernández Liguori, Nora
dc.contributor.author Lázaro, Luciana
dc.contributor.author Menichini, María Laura
dc.date.accessioned 2022-08-08T17:45:56Z
dc.date.available 2022-08-08T17:45:56Z
dc.date.issued 2022-02-09
dc.identifier.citation Barboza A, Gaitán MI, Alonso R, Ysrraelit MC, Luetic GG, Liwacki S, Patrucco L, Halfon MJ, Burgos M, Mainella C, Pierdabuena R, Recchia L, Steinberg J, Tkachuk VA, Zanga G, Carra A, Chertcoff A, Fernández Liguori N, Lazaro L, Menichini ML, Miguez J, Orzuza G, Palavecino A, Pappolla A, Pigretti S, Pita C, Ruiz E, Silva B, Zentil G. Rebound activity after fingolimod cessation: A case - control study. Mult Scler Relat Disord. 2022 Jan;57:103329. doi: 10.1016/j.msard.2021.103329 es_ES
dc.identifier.uri https://doi.org/10.1016/j.msard.2021.103329
dc.identifier.uri https://repositorio.fleni.org.ar/xmlui/handle/123456789/650
dc.description.abstract Background: There has been an increase in the number of reports of multiple sclerosis (MS) rebound activity (RA), which is usually defined as a severe disease reactivation after natalizumab or fingolimod withdrawal that exceeds pre-treatment baseline inflammatory activity. The frequency and risk factors that could predict RA remain unknown. Fingolimod is currently the most frequently prescribed disease modifying therapy for MS in Argentina, so that there is a need to determine possible predictors of RA. Objectives: To identify risk factors for developing RA after fingolimod cessation; to describe RA characteristics, management and evolution. Methods: The study was a multicenter, retrospective, case-control study of patients with MS who had discontinued fingolimod and were followed up to nine months after discontinuation. Demographic, clinical and paraclinical data was extracted, including age, gender, MS phenotype, reason for discontinuation, number of relapses during the year prior to suspension, time treated with fingolimod, EDSS before, during and after rebound, MRI findings. Results: 26 cases of RA were matched 1:1 with patients without RA. The median time elapsed to RA was 50 days. 68% showed worsening of the EDSS in the evaluation at 3 months of RA. When compared with the control group, no difference was found in terms of age, gender, phenotype, EDSS at the moment of suspension, reason for discontinuation, number of relapses in the previous year, and time on therapy. Conclusion: In this case-controlled study, no risk factors could be identified to predict RA after fingolimod cessation. Further controlled, prospective, better powered studies are needed to confirm these findings. es_ES
dc.language.iso eng es_ES
dc.publisher Elsevier es_ES
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by/2.5/ar/
dc.subject Fingolimod Hydrochloride es_ES
dc.subject Clorhidrato de Fingolimod es_ES
dc.subject Multiple Sclerosis es_ES
dc.subject Esclerosis Múltiple es_ES
dc.subject Natalizumab es_ES
dc.subject Immunosuppressive Agents es_ES
dc.subject Inmunosupresores es_ES
dc.title Rebound activity after fingolimod cessation: A case - control study es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.type info:eu-repo/semantics/publishedVersion
dc.description.fil Fil: Barboza, Andrés G. Hospital Central de Mendoza; Argentina.
dc.description.fil Fil: Gaitán, María Inés. Fleni. Departamento de Neurología. Servicio de Neuroinmunología y Enfermedades Desmielinizantes; Argentina.
dc.description.fil Fil: Alonso, Ricardo. Hospital Ramos Mejía; Argentina.
dc.description.fil Fil: Ysrraelit, María Célica. Fleni. Departamento de Neurología. Servicio de Neuroinmunología y Enfermedades Desmielinizantes; Argentina.
dc.description.fil Fil: Luetic, Geraldine G. Instituto de Neurociencias de Rosario; Argentina.
dc.description.fil Fil: Liwacki, Susana. Hospital Córdoba; Argentina.
dc.description.fil Fil: Patrucco, Liliana. Hospital Italiano de Buenos Aires; Argentina.
dc.description.fil Fil: Halfon, Mario Javier. Hospital Británico de Buenos Aires; Argentina.
dc.description.fil Fil: Burgos, Marcos. Hospital San Bernardo; Argentina.
dc.description.fil Fil: Mainella, Carolina. Hospital Español de Rosario; Argentina.
dc.description.fil Fil: Piedrabuena, Raúl. Clinica Reina Fabiola; Argentina.
dc.description.fil Fil: Recchia, Luciano. Hospital Central de Mendoza; Argentina.
dc.description.fil Fil: Steinberg, Judith. Hospital Britanico de Buenos Aires; Argentina.
dc.description.fil Fil: Tkachuk, Verónica A. Hospital de Clínicas José de San Martín; Argentina.
dc.description.fil Fil: Zanga, Gisela. ENERI; Argentina.
dc.description.fil Fil: Carra, Adriana. Hospital Británico de Buenos Aires; Argentina
dc.description.fil Fil: Chertcoff, Aníbal. Hospital Británico de Buenos Aires; Argentina.
dc.description.fil Fil: Fernández Liguori, Nora. Sanatorio Güemes; Argentina.
dc.description.fil Fil: Lázaro, Luciana. Sanatorio Güemes; Argentina.
dc.description.fil Fil: Menichini, Maria Laura. Instituto de Neurociencias de Rosario; Argentina.
dc.relation.ispartofVOLUME 57
dc.relation.ispartofCOUNTRY Países Bajos
dc.relation.ispartofCITY Amsterdam
dc.relation.ispartofTITLE Multiple sclerosis and related disorders
dc.relation.ispartofISSN 2211-0356
dc.type.snrd info:ar-repo/semantics/artículo es_ES


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