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Adaptation and validation of a Spanish version of the treatment burden questionnaire in patients with multiple sclerosis

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dc.contributor.author Ysrraelit, María Célica
dc.contributor.author Fiol, Marcela Paula
dc.contributor.author Vazquez Peña, Fernando
dc.contributor.author Vanotti, Sandra
dc.contributor.author Terrasa, Sergio Adrián
dc.contributor.author Viet-Thi, Tran
dc.contributor.author Montori, Victor M.
dc.contributor.author Correale, Jorge
dc.date.accessioned 2019-10-25T13:25:50Z
dc.date.available 2019-10-25T13:25:50Z
dc.date.issued 2019-08-27
dc.identifier.citation Ysrraelit MC, Fiol MP, Peña FV, et al. Adaptation and validation of a Spanish version of the treatment burden questionnaire in patients with multiple sclerosis. BMC Neurology. 2019;19(1):209. doi:10.1186/s12883-019-1441-0 en_US
dc.identifier.uri https://repositorio.fleni.org.ar/handle/123456789/71
dc.identifier.uri https://doi.org/10.1186/s12883-019-1441-0
dc.description.abstract Background: The Treatment Burden Questionnaire (TBQ) is a self-reported measure of the effect of treatment workload on patient wellbeing. We sought to validate the TBQ in Spanish and use it to estimate the burden of treatment in Argentinian patients with multiple sclerosis (MS). Methods: The TBQ was forward-backward translated into Spanish. Two focus groups and 25 semi-structured interviews focused on wording and possible item exclusion. Validation was performed in 2 steps. First, 162 patients across a range of MS severity completed the questionnaire. Confirmatory factor analysis assessed the dimensional structure of the TBQ. Construct validity was assessed by studying correlations with fatigue and quality of life (QoL). Then, in a second cohort of 171 patients, we evaluated the association between TBQ scores and patients’ sex, age, education level, employment status, type of MS, disease duration, comorbidities, EDSS, pharmacological treatment and medication adherence. Results: The questionnaire presented a 3-factor structure in which burden was related to pharmacological treatment; comprehensive health assistance; and psycho-social-economic context. Composite reliability was > 0.8 for all factors. TBQ showed positive correlation with fatigue (rs = 0.467, p = 0.006), negative correlation with QoL (rs − 0.446, p = 0.009). For the second cohort, total TBQ score was 43 (SD 29). Lowest scores were observed on self-monitoring (0.53, SD 1.3) and highest for administrative load (4.2, SD 3.4). Inverse association was found between the TBQ score and medication adherence (r 0.243 p = 0.001). TBQ scores also correlated with daily patient pill/injection requirements (r 0.175 p = 0.020). Individuals receiving injectable treatment scored higher than patients on oral drugs (total TBQ 51 (SD 32) vs 39 (SD 27) p = 0.002). Conclusions: The TBQ in Spanish is a reliable instrument and showed adequate correlation with QoL and adherence scales in MS patients. TBQ may benefit health resources allocation and provide tailor therapeutic interventions to construct a minimally disruptive care. en_US
dc.language.iso eng en_US
dc.publisher BioMed Central en_US
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by/2.5/ar/
dc.subject Multiple Sclerosis en_US
dc.subject Esclerosis Múltiple en_US
dc.subject Surveys and Questionnaires en_US
dc.subject Encuestas y Cuestionarios en_US
dc.title Adaptation and validation of a Spanish version of the treatment burden questionnaire in patients with multiple sclerosis en_US
dc.type info:eu-repo/semantics/publishedVersion
dc.type info:eu-repo/semantics/article en_US
dc.description.fil Fil: Ysrraelit, María Célica. Fleni. Departamento de Neurología; Argentina.
dc.description.fil Fil: Fiol, Marcela Paula. Fleni. Departamento de Neurología; Argentina.
dc.description.fil Fil: Vazquez Peña, Fernando. Hospital Italiano de Buenos Aires; Argentina.
dc.description.fil Fil: Vanotti, Sandra. Neurosciences Institute of Buenos Aires. Multiple Sclerosis Clinic; Argentina.
dc.description.fil Fil: Terrasa, Sergio Adrián. Hospital Italiano de Buenos Aires; Argentina.
dc.description.fil Fil: Viet-Thi, Tran. Centre of Research in Epidemiology and Statistics; Francia.
dc.description.fil Fil: Montori, Victor M. Mayo Clinic. Knowledge and Evaluation Research Unit; Estados Unidos.
dc.description.fil Fil: Correale, Jorge. Fleni. Departamento de Neurología. Servicio de Neuroinmunología y Enfermedades Desmielinizantes; Argentina.
dc.relation.ispartofVOLUME 19
dc.relation.ispartofNUMBER 1
dc.relation.ispartofPAGINATION 209
dc.relation.ispartofCOUNTRY Inglaterra
dc.relation.ispartofCITY Londres
dc.relation.ispartofTITLE BioMed Central neurology
dc.relation.ispartofISSN 1471-2377
dc.type.snrd info:ar-repo/semantics/artículo es_ES


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