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Incidence of COVID-19 after vaccination in people with multiple sclerosis in Argentina: Data from the nationwide registry RelevarEM

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dc.contributor.author Rojas, Juan Ignacio
dc.contributor.author Luetic, Geraldine G.
dc.contributor.author Vrech, Carlos
dc.contributor.author Pappolla, Agustín
dc.contributor.author Patrucco, Liliana
dc.contributor.author Cristiano, Edgardo
dc.contributor.author Marrodán, Mariano
dc.contributor.author Ysrraelit, María Célica
dc.contributor.author Fiol, Marcela Paula
dc.contributor.author Correale, Jorge
dc.contributor.author Cohen, Leila
dc.contributor.author Alonso, Ricardo
dc.contributor.author Silva, Berenice Anabel
dc.contributor.author Casas, Magdalena
dc.contributor.author Garcea, Orlando
dc.contributor.author Deri, Norma
dc.contributor.author Burgos, Marcos
dc.contributor.author Liwacki, Susana
dc.contributor.author Tkachuk, Verónica A.
dc.contributor.author Barboza, Andrés G.
dc.date.accessioned 2023-03-03T12:33:57Z
dc.date.available 2023-03-03T12:33:57Z
dc.date.issued 2022-12
dc.identifier.citation Rojas JI, Luetic GG, Vrech C, Pappolla A, Patrucco L, Cristiano E, Marrodan M, Ysrraelit MC, Fiol M, Correale J, Cohen L, Alonso R, Silva B, Casas M, Garcea O, Deri N, Burgos M, Liwacki S, Tkachuk V, Barboza AG, Piedrabuena R, Blaya P, Steinberg J, Martínez A, Carra A, Tavolini D, López P, Knorre E, Nofal P, Carnero Contentti E, Alves Pinheiro A, Leguizamon F, Silva E, Hryb J, Balbuena ME, Zanga G, Kohler M, Lazaro L, Tizio S, Mainella C, Blanche J, Parada Marcilla M, Fracaro ME, Menichini ML, Sgrilli G, Divi P, Jacobo M, Cabrera M, Míguez J, Fernandez Liguori N, Viglione JP, Nadur D, Alonso Serena M, Nuñez S. Incidence of COVID-19 after vaccination in people with multiple sclerosis in Argentina: Data from the nationwide registry RelevarEM. Mult Scler Relat Disord. 2022 Dec;68:104104. doi: 10.1016/j.msard.2022.104104. Epub 2022 Aug 12. es_ES
dc.identifier.uri https://doi.org/10.1016/j.msard.2022.104104
dc.identifier.uri https://repositorio.fleni.org.ar/xmlui/handle/123456789/795
dc.description.abstract The objective of the study was to evaluate the incidence of COVID-19 after complete vaccination in people with multiple sclerosis (PwMS) included in the Argentinean MS and NMOSD registry (RelevarEM, NCT03375177). Methods: cohort study conducted between May 2021 and December 2021. The primary outcome was the appearance of infection during the follow-up time (at least three months after complete vaccination (second dose)). Data was collected through the contact between the treating physician and the patient. Specific information was requested (date, symptoms, need for hospitalization, ventilatory assistance, treatment, and evolution). The contact was made every 30 days during the period of 3 months after the full dose vaccination. A positive COVID-19 case was defined according to the definition established by the Ministry of Health in Argentina. Cumulative incidence was reported by Kaplan Meier survival curves as well as incidence density. Results: A total of 576 PwMS were included, mean age 45.2 ± 13 years, 432 (75%) RRMS, 403 (70%) were female. The mean and median time of follow-up after the second dose was 91 ± 17 and 94 ± 21 days respectively. Most frequent first and second dose received was Astra-Zeneca vaccine, followed by Sputnik V vaccine. During follow-up a total of twenty COVID-19 cases were observed for a total exposure time of 39,557 days. The overall cumulative incidence for the observed period was 3.4% (SE 0.4%) with an overall incidence density of 5 × 10.000 patients/day (95%CI 0.7-12). We observed more cases in woman than men with an incidence density of 6 × 10.000 patients/day (95%CI 0.9-9) vs. 3 × 10.000 patients/day (95%CI 0.2-6) respectively, but not significantly different (IRR 1.7 95% CI 0.56-7.37 p = 0.15). Conclusion: we found an incidence density of breakthrough COVID-19 infection of 5 × 10.000 patients/day (95%CI 0.7-12) after vaccination in Argentina. es_ES
dc.language.iso eng es_ES
dc.publisher Elsevier B. V. es_ES
dc.rights info:eu-repo/semantics/openAccess
dc.subject COVID-19 es_ES
dc.subject Multiple Sclerosis es_ES
dc.subject Esclerosis Múltiple es_ES
dc.subject Argentina es_ES
dc.title Incidence of COVID-19 after vaccination in people with multiple sclerosis in Argentina: Data from the nationwide registry RelevarEM es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.type info:eu-repo/semantics/publishedVersion
dc.description.fil Fil: Rojas, Juan Ignacio. Hospital Universitario de CEMIC; Argentina.
dc.description.fil Fil: Luetic, Geraldine. Instituto de Neurociencias de Rosario; Argentina.
dc.description.fil Fil: Vrech, Carlos. Instituto de Neurociencias de Rosario; Argentina.
dc.description.fil Fil: Pappolla, Agustín. Hospital Italiano de Buenos Aires, Buenos Aires; Argentina.
dc.description.fil Fil: Marrodán, Mariano. Fleni. Departamento de Neurología. Servicio de Neuroinmunología y Enfermedades Desmielinizantes; Argentina.
dc.description.fil Fil: Ysrraelit, Maria Célica. Fleni. Departamento de Neurología. Servicio de Neuroinmunología y Enfermedades Desmielinizantes; Argentina.
dc.description.fil Fil: Fiol, Marcela Paula. Fleni. Departamento de Neurología. Servicio de Neuroinmunología y Enfermedades Desmielinizantes; Argentina.
dc.description.fil Fil: Correale, Jorge. Fleni. Departamento de Neurología. Servicio de Neuroinmunología y Enfermedades Desmielinizantes; Argentina.
dc.relation.ispartofVOLUME 68
dc.relation.ispartofPAGINATION 104104
dc.relation.ispartofCOUNTRY Países Bajos
dc.relation.ispartofCITY Ámsterdam
dc.relation.ispartofTITLE Multiple sclerosis and related disorders
dc.relation.ispartofISSN 2211-0356
dc.type.snrd info:ar-repo/semantics/artículo es_ES


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