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Pathogenesis of Alzheimer's disease: Involvement of the choroid plexus

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dc.contributor.author Čarna, Maria
dc.contributor.author Onyango, Isaac G.
dc.contributor.author Katina, Stanislav
dc.contributor.author Holub, Dušan
dc.contributor.author Novotny, Jan Sebastian
dc.contributor.author Nezvedova, Marketa
dc.contributor.author Jha, Durga
dc.contributor.author Nedelska, Zuzana
dc.contributor.author Lacovich, Valentina
dc.contributor.author Vande Vyvere, Thijs
dc.contributor.author Houbrechts, Ruben
dc.contributor.author Garcia-Mansfield, Krystine
dc.contributor.author Sharma, Ritin
dc.contributor.author David-Dirgo, Victoria
dc.contributor.author Vyhnalek, Martin
dc.contributor.author Texlova, Kateřina
dc.contributor.author Chaves, Hernán
dc.contributor.author Bakkar, Nadine
dc.contributor.author Pertierra, Lucía
dc.contributor.author Sevlever, Gustavo Emilio
dc.date.accessioned 2023-09-07T16:08:06Z
dc.date.available 2023-09-07T16:08:06Z
dc.date.issued 2023-02-24
dc.identifier.citation Čarna, M., Onyango, I.G., Katina, S., Holub, D., Novotny, J.S., Nezvedova, M., Jha, D., Nedelska, Z., Lacovich, V., Vyvere, T.V., Houbrechts, R., Garcia-Mansfield, K., Sharma, R., David-Dirgo, V., Vyhnalek, M., Texlova, K., Chaves, H., Bakkar, N., Pertierra, L., Vinkler, M., Markova, H., Laczo, J., Sheardova, K., Hortova-Kohoutkova, M., Frič, J., Forte, G., Kaňovsky, P., Belaškova, S., Damborsky, J., Hort, J., Seyfried, N.T., Bowser, R., Sevlever, G., Rissman, R.A., Smith, R.A., Hajduch, M., Pirrotte, P., Spacil, Z., Dammer, E.B., Limbäck-Stokin, C., Stokin, G.B., 2023. Pathogenesis of Alzheimer’s disease: Involvement of the choroid plexus. Alzheimers Dement. https://doi.org/10.1002/alz.12970 es_ES
dc.identifier.uri https://doi.org/10.1002/alz.12970
dc.identifier.uri https://repositorio.fleni.org.ar/xmlui/handle/123456789/828
dc.description.abstract The choroid plexus (ChP) produces and is bathed in the cerebrospinal fluid (CSF), which in aging and Alzheimer's disease (AD) shows extensive proteomic alterations including evidence of inflammation. Considering inflammation hampers functions of the involved tissues, the CSF abnormalities reported in these conditions are suggestive of ChP injury. Indeed, several studies document ChP damage in aging and AD, which nevertheless remains to be systematically characterized. We here report that the changes elicited in the CSF by AD are consistent with a perturbed aging process and accompanied by aberrant accumulation of inflammatory signals and metabolically active proteins in the ChP. Magnetic resonance imaging (MRI) imaging shows that these molecular aberrancies correspond to significant remodeling of ChP in AD, which correlates with aging and cognitive decline. Collectively, our preliminary post-mortem and in vivo findings reveal a repertoire of ChP pathologies indicative of its dysfunction and involvement in the pathogenesis of AD. HIGHLIGHTS: Cerebrospinal fluid changes associated with aging are perturbed in Alzheimer's disease Paradoxically, in Alzheimer's disease, the choroid plexus exhibits increased cytokine levels without evidence of inflammatory activation or infiltrates In Alzheimer's disease, increased choroid plexus volumes correlate with age and cognitive performance. es_ES
dc.language.iso eng es_ES
dc.publisher Wiley es_ES
dc.rights info:eu-repo/semantics/openAccess
dc.subject Alzheimer Disease es_ES
dc.subject Enfermedad de Alzheimer es_ES
dc.subject Choroid Plexus es_ES
dc.subject Plexo Coroideo es_ES
dc.subject Inflammation es_ES
dc.subject Inflamación es_ES
dc.subject Proteomics es_ES
dc.subject Proteómica es_ES
dc.title Pathogenesis of Alzheimer's disease: Involvement of the choroid plexus es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.type info:eu-repo/semantics/publishedVersion
dc.description.fil Fil: Chaves, Hernán. Fleni. Departamento de Diagnóstico por Imágenes; Argentina.
dc.description.fil Fil: Pertierra, Lucía. Fleni. Departamento de Neurología. Servicio de Neurología Cognitiva, Neuropsicología y Neuropsiquiatría. Centro de Memoria y Envejecimiento; Argentina.
dc.description.fil Fil: Sevlever, Gustavo Emilio. Fleni. Departamento de Neuropatología y Biología Molecular; Argentina.
dc.relation.ispartofVOLUME 19
dc.relation.ispartofNUMBER 8
dc.relation.ispartofPAGINATION 3537-3554
dc.relation.ispartofCOUNTRY Estados Unidos
dc.relation.ispartofCITY Hoboken
dc.relation.ispartofTITLE Alzheimer's & dementia
dc.relation.ispartofISSN 1552-5279
dc.type.snrd info:ar-repo/semantics/artículo es_ES


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