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Pattern and implications of neurological examination findings in autosomal dominant Alzheimer disease

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dc.contributor.author Vöglein, Jonathan
dc.contributor.author Franzmeier, Nicolai
dc.contributor.author Morris, John C.
dc.contributor.author Dieterich, Marianne
dc.contributor.author McDade, Eric
dc.contributor.author Simon, Mikael
dc.contributor.author Preische, Oliver
dc.contributor.author Hofmann, Anna
dc.contributor.author Hassenstab, Jason
dc.contributor.author Benzinger, Tammie L.S.
dc.contributor.author Fagan, Anne M.
dc.contributor.author Noble, James M.
dc.contributor.author Berman, Sarah B.
dc.contributor.author Graff-Radford, Neill R.
dc.contributor.author Ghetti, Bernardino
dc.contributor.author Farlow, Martin R.
dc.contributor.author Chhatwal, Jasmeer P.
dc.contributor.author Chrem Méndez, Patricio Alexis
dc.contributor.author Allegri, Ricardo Francisco
dc.contributor.author Dominantly Inherited Alzheimer Network
dc.date.accessioned 2023-12-18T11:54:39Z
dc.date.available 2023-12-18T11:54:39Z
dc.date.issued 2022-05-24
dc.identifier.citation Vöglein J, Franzmeier N, Morris JC, Dieterich M, McDade E, Simons M, Preische O, Hofmann A, Hassenstab J, Benzinger TLS, Fagan AM, Noble JM, Berman SB, Graff-Radford NR, Ghetti B, Farlow MR, Chhatwal JP, Salloway S, Xiong C, Karch CM, Cairns N, Perrin RJ, Day G, Martins R, Sanchez-Valle R, Mori H, Shimada H, Ikeuchi T, Suzuki K, Schofield PR, Masters CL, Goate A, Buckles V, Fox NC, Chrem Méndez, PA, Allegri R, Ringman JM, Yakushev I, Laske C, Jucker M, Höglinger G, Bateman RJ, Danek A, Levin J; Dominantly Inherited Alzheimer Network. Pattern and implications of neurological examination findings in autosomal dominant Alzheimer disease. Alzheimers Dement. 2023 Feb;19(2):632-645. doi: 10.1002/alz.12684. Epub 2022 May 24. es_ES
dc.identifier.uri https://doi.org/10.1002/alz.12684
dc.identifier.uri https://repositorio.fleni.org.ar/xmlui/handle/123456789/912
dc.description.abstract Introduction: As knowledge about neurological examination findings in autosomal dominant Alzheimer disease (ADAD) is incomplete, we aimed to determine the frequency and significance of neurological examination findings in ADAD. Methods: Frequencies of neurological examination findings were compared between symptomatic mutation carriers and non mutation carriers from the Dominantly Inherited Alzheimer Network (DIAN) to define AD neurological examination findings. AD neurological examination findings were analyzed regarding frequency, association with and predictive value regarding cognitive decline, and association with brain atrophy in symptomatic mutation carriers. Results: AD neurological examination findings included abnormal deep tendon reflexes, gait disturbance, pathological cranial nerve examination findings, tremor, abnormal finger to nose and heel to shin testing, and compromised motor strength. The frequency of AD neurological examination findings was 65.1%. Cross-sectionally, mutation carriers with AD neurological examination findings showed a more than two-fold faster cognitive decline and had greater parieto-temporal atrophy, including hippocampal atrophy. Longitudinally, AD neurological examination findings predicted a significantly greater decline over time. Discussion: ADAD features a distinct pattern of neurological examination findings that is useful to estimate prognosis and may inform clinical care and therapeutic trial designs. Keywords: Alzheimer disease; autosomal dominant Alzheimer disease; differential diagnosis; neurological examination; neurological examination findings; predictive value; prognosis. es_ES
dc.language.iso eng es_ES
dc.publisher John Wiley & Sons es_ES
dc.subject Alzheimer Disease es_ES
dc.subject Enfermedad de Alzheimer es_ES
dc.title Pattern and implications of neurological examination findings in autosomal dominant Alzheimer disease es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.description.fil Fil: Allegri, Ricardo Francisco. Fleni. Departamento de Neurología. Servicio de Neurología Cognitiva, Neuropsicología y Neuropsiquiatría; Argentina.
dc.description.fil Fil: Chrem Méndez, Patricio Alexis. Fleni. Departamento de Neurología. Servicio de Neurología Cognitiva, Neuropsicología y Neuropsiquiatría; Argentina.
dc.description.fil Fil: Vöglein, Jonathan. German Center for Neurodegenerative Diseases; Alemania.
dc.description.fil Fil: Franzmeier, Nicolai. German Center for Neurodegenerative Diseases; Alemania.
dc.description.fil Fil: Morris, John C. Washington University School of Medicine; Estados Unidos.
dc.description.fil Fil: Dieterich, Marianne. German Center for Neurodegenerative Diseases; Alemania.
dc.description.fil Fil: McDade, Eric. Washington University School of Medicine; Estados Unidos.
dc.description.fil Fil: Simon, Mikael. German Center for Neurodegenerative Diseases; Alemania.
dc.description.fil Fil: Preische, Oliver. German Center for Neurodegenerative Diseases; Alemania.
dc.description.fil Fil: Hofmann, Anna. German Center for Neurodegenerative Diseases; Alemania.
dc.description.fil Fil: Hassenstab, Jason. German Center for Neurodegenerative Diseases; Alemania.
dc.description.fil Fil: Benzinger, Tammie L.S. German Center for Neurodegenerative Diseases; Alemania.
dc.description.fil Fil: Fagan, Anne M. German Center for Neurodegenerative Diseases; Alemania.
dc.description.fil Fil: Noble, James M. Columbia University Irving Medical Center; Estados Unidos.
dc.description.fil Fil: Berman, Sarah B. University of Pittsburgh; Estados Unidos.
dc.description.fil Fil: Graff-Radford, Neill R. Mayo Clinic; Estados Unidos.
dc.description.fil Fil: Ghetti, Bernardino. Indiana University School of Medicine; Estados Unidos.
dc.description.fil Fil: Farlow, Martin R. Indiana University School of Medicine; Estados Unidos.
dc.description.fil Fil: Chhatwal, Jasmeer P. Harvard Medical School; Estados Unidos.
dc.relation.ispartofVOLUME 19
dc.relation.ispartofNUMBER 2
dc.relation.ispartofPAGINATION 632-645.
dc.relation.ispartofCOUNTRY Estados Unidos
dc.relation.ispartofCITY Hoboken
dc.relation.ispartofTITLE Alzheimer's & dementia : the journal of the Alzheimer's Association
dc.type.snrd info:ar-repo/semantics/artículo es_ES


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