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From the prodromal stage of multiple sclerosis to disease prevention

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dc.contributor.author Marrie, Ruth Ann
dc.contributor.author Allegretta, Mark
dc.contributor.author Barcellos, Lisa F.
dc.contributor.author Bebo, Bruce
dc.contributor.author Calabresi, Peter A.
dc.contributor.author Correale, Jorge
dc.contributor.author Davis, Benjamin
dc.contributor.author De Jager, Philip L.
dc.contributor.author Gasperi, Christiane
dc.contributor.author Greenbaum, Carla
dc.contributor.author Helme, Anne
dc.contributor.author Hemmer, Bernhard
dc.contributor.author Kanellis, Pamela
dc.contributor.author Kostich, Walter
dc.contributor.author Landsman, Douglas
dc.contributor.author Lebrun-Frenay, Christine
dc.contributor.author Makhani, Naila
dc.contributor.author Munger, Kassandra L.
dc.contributor.author Okuda, Darin T.
dc.contributor.author Ontaneda, Daniel
dc.date.accessioned 2023-12-19T14:17:02Z
dc.date.available 2023-12-19T14:17:02Z
dc.date.issued 2022-07-15
dc.identifier.citation Marrie RA, Allegretta M, Barcellos LF, Bebo B, Calabresi PA, Correale J, Davis B, De Jager PL, Gasperi C, Greenbaum C, Helme A, Hemmer B, Kanellis P, Kostich W, Landsman D, Lebrun-Frenay C, Makhani N, Munger KL, Okuda DT, Ontaneda D, Postuma RB, Quandt JA, Roman S, Saidha S, Sormani MP, Strum J, Valentine P, Walton C, Zackowski KM, Zhao Y, Tremlett H. From the prodromal stage of multiple sclerosis to disease prevention. Nat Rev Neurol. 2022 Sep;18(9):559-572. doi: 10.1038/s41582-022-00686-x. Epub 2022 Jul 15. es_ES
dc.identifier.uri https://doi.org/10.1038/s41582-022-00686-x
dc.identifier.uri https://repositorio.fleni.org.ar/xmlui/handle/123456789/920
dc.description.abstract A prodrome is an early set of signs or symptoms that indicate the onset of a disease before more typical symptoms develop. Prodromal stages are well recognized in some neurological and immune-mediated diseases such as Parkinson disease, schizophrenia, type 1 diabetes mellitus and rheumatoid arthritis. Emerging evidence indicates that a prodromal stage exists in multiple sclerosis (MS), raising the possibility of intervention at this stage to delay or prevent the development of classical MS. However, much remains unclear about the prodromal stage of MS and considerable research is needed to fully characterize the prodrome and develop standardized criteria to reliably identify individuals with prodromal MS who are at high risk of progressing to a diagnosis of MS. In this Roadmap, we draw on work in other diseases to propose a disease framework for MS that incorporates the prodromal stage, and set out key steps and considerations needed in future research to fully characterize the MS prodrome, identify early disease markers and develop standardized criteria that will enable reliable identification of individuals with prodromal MS, thereby facilitating trials of interventions to slow or stop progression beyond the prodrome. es_ES
dc.language.iso eng es_ES
dc.publisher Nature Pub. Group es_ES
dc.subject Multiple Sclerosis es_ES
dc.subject Esclerosis Múltiple es_ES
dc.title From the prodromal stage of multiple sclerosis to disease prevention es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.description.fil Fil: Correale, Jorge. Fleni. Departamento de Neurología. Servicio de Neuroinmunología y Enfermedades Desmielinizantes; Argentina.
dc.description.fil Fil: Marrie, Ruth Ann. University of Manitoba; Canadá.
dc.description.fil Fil: Allegretta, Mark. National Multiple Sclerosis Society; Estados Unidos.
dc.description.fil Fil: Barcellos, Lisa F. University of California; Estados Unidos.
dc.description.fil Fil: Bebo, Bruce. National Multiple Sclerosis Society; Estados Unidos.
dc.description.fil Fil: Davis, Benjamin. Multiple Sclerosis Society of Canada; Canadá.
dc.description.fil Fil: De Jager, Philip L. University Irving Medical Center; Estados Unidos.
dc.description.fil Fil: Gasperi, Christiane. Technical University of Munich; Alemania.
dc.description.fil Fil: Greenbaum, Carla. Benaroya Research Institute; Estados Unidos.
dc.description.fil Fil: Helme, Anne. Multiple Sclerosis International Federation; Reino Unido.
dc.description.fil Fil: Hemmer, Bernhard. Technical University of Munich; Alemania.
dc.description.fil Fil: Kanellis, Pamela. Multiple Sclerosis Society of Canada; Canadá.
dc.description.fil Fil: Kostich, Walter. National Multiple Sclerosis Society; Estados Unidos.
dc.description.fil Fil: Landsman, Douglas. National Multiple Sclerosis Society; Estados Unidos.
dc.description.fil Fil: Lebrun-Frenay, Christine. Université Nice Cote d'Azur Nice; Francia.
dc.description.fil Fil: Makhani, Naila. Yale School of Medicine; Estados Unidos.
dc.description.fil Fil: Munger, Kassandra L. Harvard TH Chan School of Public Health; Estados Unidos.
dc.description.fil Fil: Okuda, Darin T. The University of Texas Southwestern Medical Center; Estados Unidos.
dc.description.fil Fil: Ontaneda, Daniel. Cleveland Clinic; Estados Unidos.
dc.relation.ispartofCOUNTRY Reino Unido
dc.relation.ispartofCITY Londres
dc.relation.ispartofTITLE Nature reviews. Neurology.
dc.relation.ispartofISSN 1759-4766
dc.type.snrd info:ar-repo/semantics/artículo es_ES


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