dc.contributor.author |
Camerlingo, Sebastián |
|
dc.contributor.author |
Rubinstein, Fernando |
|
dc.contributor.author |
Ysrraelit, María Célica |
|
dc.contributor.author |
Correale, Jorge |
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dc.contributor.author |
Carnero Contentti, Edgar |
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dc.contributor.author |
Rojas, Juan Ignacio |
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dc.contributor.author |
Patrucco, Liliana |
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dc.contributor.author |
Del Valle Leguizamon, Felisa |
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dc.contributor.author |
Tkachuk, Verónica A. |
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dc.contributor.author |
Fernández Liguori, Nora |
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dc.contributor.author |
Cristiano, Edgardo |
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dc.contributor.author |
Mainella, Carolina |
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dc.contributor.author |
Zanga, Gisela |
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dc.contributor.author |
Carrá, Adriana |
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dc.contributor.author |
Marrodán, Mariano |
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dc.contributor.author |
Martínez, Alejandra Diana |
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dc.contributor.author |
Silva, Berenice Anabel |
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dc.contributor.author |
Alonso, Ricardo |
|
dc.date.accessioned |
2024-01-29T11:04:54Z |
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dc.date.available |
2024-01-29T11:04:54Z |
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dc.date.issued |
2024-01-21 |
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dc.identifier.citation |
Camerlingo S, Rubinstein F, Celia Ysrraelit M, Correale J, Carnero Contentti E, Rojas JI, Patrucco L, Leguizamon FDV, Tkachuk V, Fernandez Liguori N, Cristiano E, Mainella C, Zanga G, Carra A, Marrodan M, Martinez AD, Silva BA, Alonso R. Clinical impact of gender and age at onset on disease trajectory in primary progressive multiple sclerosis patients. Mult Scler. 2024 Jan 21:13524585231219138. doi: 10.1177/13524585231219138. Epub ahead of print |
es_ES |
dc.identifier.uri |
https://doi.org/10.1177/13524585231219138 |
|
dc.identifier.uri |
https://repositorio.fleni.org.ar/xmlui/handle/123456789/959 |
|
dc.description.abstract |
Background and objectives: Primary-progressive multiple sclerosis (PPMS) is characterized by gradual neurological deterioration without relapses. This study aimed to investigate the clinical impact of gender and age at disease onset on disease progression and disability accumulation in patients with this disease phenotype.
Methods: Secondary data from the RelevarEM registry, a longitudinal database in Argentina, were analyzed. The cohort comprised patients with PPMS who met inclusion criteria. Statistical analysis with multilevel Bayesian robust regression modeling was conducted to assess the associations between gender, age at onset, and Expanded Disability Status Scale (EDSS) score trajectories.
Results: We identified 125 patients with a confirmed diagnosis of PPMS encompassing a total of 464 observations. We found no significant differences in EDSS scores after 10 years of disease progression between genders (-0.08; credible interval (CI): -0.60, 0.42). A 20-year difference in age at onset did not show significant differences in EDSS score after 10 years of disease progression (0.281; CI: -0.251, 0.814). Finally, we also did not find any clinically relevant difference between gender EDSS score with a difference of 20 years in age at onset (-0.021; CI: -0.371, 0.319).
Conclusion: Biological plausibility of gender and age effects does not correlate with clinical impact measured by EDSS score. |
es_ES |
dc.language.iso |
eng |
es_ES |
dc.publisher |
Sage Publications |
es_ES |
dc.relation.ispartof |
Londres |
|
dc.subject |
Multiple Sclerosis |
es_ES |
dc.subject |
Esclerosis Múltiple |
es_ES |
dc.subject |
Demyelinating Diseases |
|
dc.subject |
Enfermedades Desmielinizantes |
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dc.title |
Clinical impact of gender and age at onset on disease trajectory in primary progressive multiple sclerosis patients |
es_ES |
dc.type |
info:eu-repo/semantics/article |
es_ES |
dc.description.fil |
Fil: Camerlingo, Sebastián. Instituto de Efectividad Clínica y Sanitaria; Argentina. |
|
dc.description.fil |
Fil: Rubinstein, Fernando. Instituto de Efectividad Clínica y Sanitaria; Argentina. |
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dc.description.fil |
Fil: Ysrraelit, Maria Célica. Fleni. Departamento de Neurología. Servicio de Neuroinmunología y Enfermedades Desmielinizantes; Argentina. |
|
dc.description.fil |
Fil: Correale, Jorge. Fleni. Departamento de Neurología. Servicio de Neuroinmunología y Enfermedades Desmielinizantes; Argentina. |
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dc.description.fil |
Fil: Carnero Contentti, Edgar. Hospital Alemán; Argentina. |
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dc.description.fil |
Fil: Rojas, Juan Ignacio. Centro de Esclerosis Múltiple Buenos Aires; Argentina. |
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dc.description.fil |
Fil: Patrucco, Liliana. Centro de Esclerosis Múltiple Buenos Aires; Argentina. |
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dc.description.fil |
Fil: Del Valle Leguizamon, Felisa. Hospital General de Agudos Dr. Teodoro Alvarez; Argentina. |
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dc.description.fil |
Fil: Tkachuk, Verónica A. Hospital de Clínicas José de San Martín; Argentina. |
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dc.description.fil |
Fil: Fernández Liguori, Nora. Hospital Enrique Tornú; Argentina. |
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dc.description.fil |
Fil: Cristiano, Edgardo. Centro de Esclerosis Múltiple Buenos Aires; Argentina. |
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dc.description.fil |
Fil: Mainella, Carolina. Hospital Español; Argentina. |
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dc.description.fil |
Fil: Zanga, Gisela. Hospital Dr. César Milstein; Argentina. |
|
dc.description.fil |
Fil: Carrá, Adriana. Hospital Británico; Argentina. |
|
dc.description.fil |
Fil: Marrodán, Mariano. Fleni. Departamento de Neurología. Servicio de Neuroinmunología y Enfermedades Desmielinizantes; Argentina. |
|
dc.description.fil |
Fil: Martínez, Alejandra Diana. Hospital Británico; Argentina. |
|
dc.description.fil |
Fil: Silva, Berenice Anabel. Hospital Italiano; Argentina. |
|
dc.description.fil |
Fil: Alonso, Ricardo. Hospital Ramos Mejía; Argentina. |
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dc.relation.ispartofPAGINATION |
13524585231219138 |
|
dc.relation.ispartofCOUNTRY |
Reino Unido |
|
dc.relation.ispartofTITLE |
Multiple sclerosis : clinical and laboratory research |
|
dc.relation.ispartofISSN |
1477-0970 |
|
dc.type.snrd |
info:ar-repo/semantics/artículo |
es_ES |