Mostrar el registro sencillo del ítem
dc.contributor.author | Rojas, Juan Ignacio | |
dc.contributor.author | Alonso, Ricardo | |
dc.contributor.author | Cabrera, Mariela | |
dc.contributor.author | Carnero Contentti, Edgar | |
dc.contributor.author | Cristiano, Edgardo | |
dc.contributor.author | Deri, Norma | |
dc.contributor.author | Hryb, Javier Pablo | |
dc.contributor.author | López, Pablo Adrián | |
dc.contributor.author | Luetic, Geraldine G. | |
dc.contributor.author | Patrucco, Liliana | |
dc.contributor.author | Tkachuk, Verónica A. | |
dc.contributor.author | Ysrraelit, María Célica | |
dc.contributor.author | Zanga, Gisela | |
dc.contributor.author | Cruces, Leonel | |
dc.contributor.author | Turk, Gabriela | |
dc.contributor.author | Longueira, Yesica | |
dc.contributor.author | Laufer, Natalia | |
dc.contributor.author | Nuñez, Sebastián | |
dc.date.accessioned | 2024-02-01T17:15:36Z | |
dc.date.available | 2024-02-01T17:15:36Z | |
dc.date.issued | 2023-03-02 | |
dc.identifier.citation | Rojas JI, Alonso R, Cabrera M, Carnero Contentti E, Cristiano E, Deri N, Hryb J, Lopez P, Luetic G, Patrucco L, Tkachuk V, Ysrraelit MC, Zanga G, Cruces L, Turk G, Longueira Y, Laufer N, Nuñez S. Serological response to SARS-CoV-2 vaccines in patients with multiple sclerosis in Argentina. Medicina (B Aires). 2023;83(3):358-365. | es_ES |
dc.identifier.uri | https://www.medicinabuenosaires.com/PMID/37379532.pdf | |
dc.identifier.uri | https://repositorio.fleni.org.ar/xmlui/handle/123456789/970 | |
dc.description.abstract | Introduction: The objective was to assess the immunogenicity and effectiveness of vaccines against SARSCoV-2 in multiple sclerosis (MS) patients included in the Argentinean MS registry. Methods: A prospective cohort study between May and December 2021. The primary outcome was immunogenicity and effectiveness of vaccines during a three-month follow-up. Immunogenicity was evaluated based on detection of total antibodies (Ab) against spike protein and neutralizing Ab in serum 4 weeks after the second vaccine dose. A positive COVID-19 case was defined according to Argentinean Ministry of Health. Results: 94 patients were included, mean age: 41.7 ± 12.1 years. Eighty (85.1%) had relapsing remitting multiple sclerosis (RRMS); 30 (31.9%) were under fingolimod treatment. The Sputnik V vaccine was the first dose in 33 (35.1%), and AstraZeneca in 61 (64.9%). In 60 (63.8%), the vaccine elicited a specific humoral response. Immunological response according to the vaccination schemes showed no qualitative differences (p = 0.45). Stratified analysis according to the MS treatment showed that a significantly smaller number of subjects developed antibodies against spike antigen among those that were on ocrelizumab compared to other groups (p = 0.001), while a reduced number of patients under ocrelizumab where evaluated (n = 7). This was also observed for neutralizing antibodies in the ocrelizumab group (p < 0.001). During the three-month follow-up, two individuals were diagnosed with COVID-19. Conclusion: We found that MS patients that received Sputnik V or AstraZeneca vaccines for SARS-CoV-2 developed a serological response with no differences between the vaccines used. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Fundación Revista Medicina | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | Antibodies | es_ES |
dc.subject | Anticuerpos | es_ES |
dc.subject | Argentina | es_ES |
dc.subject | COVID-19 | es_ES |
dc.subject | Multiple Sclerosis | es_ES |
dc.subject | Esclerosis Múltiple | es_ES |
dc.subject | SARS-CoV-2 | es_ES |
dc.subject | Vaccination | es_ES |
dc.subject | Vacunación | es_ES |
dc.title | Serological response to SARS-CoV-2 vaccines in patients with multiple sclerosis in Argentina | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.type | info:eu-repo/semantics/publishedVersion | |
dc.description.fil | Fil: Ysrraelit, Maria Célica. Fleni. Departamento de Neurología. Servicio de Neuroinmunología y Enfermedades Desmielinizantes; Argentina. | |
dc.relation.ispartofVOLUME | 83 | |
dc.relation.ispartofNUMBER | 3 | |
dc.relation.ispartofPAGINATION | 358-365 | |
dc.relation.ispartofCOUNTRY | Argentina | |
dc.relation.ispartofCITY | Buenos Aires | |
dc.relation.ispartofTITLE | Medicina | |
dc.relation.ispartofISSN | 1669-9106 | |
dc.type.snrd | info:ar-repo/semantics/artículo | es_ES |