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Incidence of SARS-CoV-2 infection in patients with multiple sclerosis who received SARS-CoV-2 vaccines and are under treatment with high-efficacy therapies in Argentina

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dc.contributor.author Carnero Contentti, Edgar
dc.contributor.author López, Pablo Adrián
dc.contributor.author Pappolla, Agustín
dc.contributor.author Alonso, Ricardo
dc.contributor.author Silva, Berenice Anabel
dc.contributor.author Deri, Norma
dc.contributor.author Balbuena Aguirre, María Eugenia
dc.contributor.author Burgos, Marcos
dc.contributor.author Luetic, Geraldine G.
dc.contributor.author Alvez Pinheiro, Amelia
dc.contributor.author Cabrera, Mariela
dc.contributor.author Hryb, Javier Pablo
dc.contributor.author Nofal, Pedro G.
dc.contributor.author Pestchanker, Claudia
dc.contributor.author Vrech, Carlos
dc.contributor.author Tavolini, Darío
dc.contributor.author Marrodán, Mariano
dc.contributor.author Ysrraelit, María Célica
dc.contributor.author Correale, Jorge
dc.contributor.author RelevarEM investigators
dc.date.accessioned 2024-02-20T11:28:21Z
dc.date.available 2024-02-20T11:28:21Z
dc.date.issued 2023-12-30
dc.identifier.citation Carnero Contentti E, López PA, Pappolla A, Alonso R, Silva B, Deri N, Balbuena ME, Burgos M, Luetic G, Alvez Pinheiro A, Cabrera M, Hryb J, Nofal P, Pestchanker C, Vrech C, Tavolini D, Tkachuk V, Zanga G, Marrodan M, Ysrraelit MC, Correale J, Carrá A, Federico B, Garcea O, Fernandez Liguori N, Patrucco L, Cristiano E, Giunta D, Alonso Serena M, Rojas JI; on behalf RelevarEM. Incidence of SARS-CoV-2 infection in patients with multiple sclerosis who received SARS-CoV-2 vaccines and are under treatment with high-efficacy therapies in Argentina. Neurol Sci. 2024 Feb;45(2):379-389. doi: 10.1007/s10072-023-07282-x. Epub 2023 Dec 30. es_ES
dc.identifier.uri https://doi.org/10.1007/s10072-023-07282-x
dc.identifier.uri https://repositorio.fleni.org.ar/xmlui/handle/123456789/998
dc.description.abstract We aimed to evaluate the incidence of SARS-CoV-2 breakthrough infection of SARS-CoV-2 vaccines in people with MS (PwMS) on high-efficacy disease-modifying therapies (HET) included in the national MS registry in Argentina (RelevarEM). Methods: Non-interventional, retrospective cohort study that collected information directly from RelevarEM. Adult PwMS who had been treated for at least 6 months with a HET (ocrelizumab, natalizumab, alemtuzumab, cladribine) who had received at least two doses of SARS-CoV-2 vaccines available in Argentina were included. Full course of vaccination was considered after the second dose of the corresponding vaccines. Cumulative incidence of SARS-CoV-2 infection was reported for the whole cohort by Kaplan-Meier survival curves (which is expressed in percentage) as well as incidence density (which is expressed per 10.000 patients/day with 95% CI). Results: Two hundred twenty-eight PwMS were included. Most frequent first and second dose received was AstraZeneca vaccine, followed by Sputnik vaccine. Most frequent HETs used in included patients were cladribine in 79 (34.8%). We found an incidence density of breakthrough COVID-19 infection of 3.5 × 10.000 patients/day (95% CI 2.3-6.7) after vaccination in Argentina. We described the incidence rate after vaccination for every HET used, it being significantly higher for ocrelizumab compared with other HETs (p = 0.005). Only five patients presented a relapse during the follow-up period with no differences regarding the pre-vaccination period. Conclusions: We found an incidence density of breakthrough COVID-19 infection of 3.5 × 10.000 patients/day (95% CI 2.3-6.7) after vaccination in Argentina. es_ES
dc.language.iso eng es_ES
dc.publisher Springer-Verlag Italia es_ES
dc.subject Esclerosis Múltiple es_ES
dc.subject Multiple Sclerosis es_ES
dc.subject Argentina es_ES
dc.title Incidence of SARS-CoV-2 infection in patients with multiple sclerosis who received SARS-CoV-2 vaccines and are under treatment with high-efficacy therapies in Argentina es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.description.fil Fil: Marrodán, Mariano. Fleni. Departamento de Neurología. Servicio de Neuroinmunología y Enfermedades Desmielinizantes; Argentina.
dc.description.fil Fil: Ysrraelit, María Célica. Fleni. Departamento de Neurología. Servicio de Neuroinmunología y Enfermedades Desmielinizantes; Argentina.
dc.description.fil Fil: Correale, Jorge. Fleni. Departamento de Neurología. Servicio de Neuroinmunología y Enfermedades Desmielinizantes; Argentina.
dc.relation.ispartofNUMBER 2
dc.relation.ispartofPAGINATION 379-389.
dc.relation.ispartofTITLE Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
dc.relation.ispartofISSN 1590-3478
dc.type.snrd info:ar-repo/semantics/artículo es_ES


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