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Microglia-derived extracellular vesicles in homeostasis and demyelination/remyelination processes

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dc.contributor.author Wies Mancini, Victoria Sofía Berenice
dc.contributor.author Mattera, Vanesa S.
dc.contributor.author Pasquini, Juana María
dc.contributor.author Pasquini, Laura Andrea
dc.contributor.author Correale, Jorge
dc.date.accessioned 2024-02-20T12:19:10Z
dc.date.available 2024-02-20T12:19:10Z
dc.date.issued 2023-12-06
dc.identifier.citation Wies Mancini VSB, Mattera VS, Pasquini JM, Pasquini LA, Correale JD. Microglia-derived extracellular vesicles in homeostasis and demyelination/remyelination processes. J Neurochem. 2024 Jan;168(1):3-25. doi: 10.1111/jnc.16011. Epub 2023 Dec 6. es_ES
dc.identifier.uri https://doi.org/10.1111/jnc.16011
dc.identifier.uri https://repositorio.fleni.org.ar/xmlui/handle/123456789/999
dc.description.abstract Microglia (MG) play a crucial role as the predominant myeloid cells in the central nervous system and are commonly activated in multiple sclerosis. They perform essential functions under normal conditions, such as actively surveying the surrounding parenchyma, facilitating synaptic remodeling, engulfing dead cells and debris, and protecting the brain against infectious pathogens and harmful self-proteins. Extracellular vesicles (EVs) are diverse structures enclosed by a lipid bilayer that originate from intracellular endocytic trafficking or the plasma membrane. They are released by cells into the extracellular space and can be found in various bodily fluids. EVs have recently emerged as a communication mechanism between cells, enabling the transfer of functional proteins, lipids, different RNA species, and even fragments of DNA from donor cells. MG act as both source and recipient of EVs. Consequently, MG-derived EVs are involved in regulating synapse development and maintaining homeostasis. These EVs also directly influence astrocytes, significantly increasing the release of inflammatory cytokines like IL-1β, IL-6, and TNF-α, resulting in a robust inflammatory response. Furthermore, EVs derived from inflammatory MG have been found to inhibit remyelination, whereas Evs produced by pro-regenerative MG effectively promote myelin repair. This review aims to provide an overview of the current understanding of MG-derived Evs, their impact on neighboring cells, and the cellular microenvironment in normal conditions and pathological states, specifically focusing on demyelination and remyelination processes. es_ES
dc.language.iso eng es_ES
dc.publisher Wiley on behalf of the International Society for Neurochemistry es_ES
dc.subject Microglia es_ES
dc.subject Microglía es_ES
dc.subject Remielinización es_ES
dc.subject Remyelination es_ES
dc.subject Enfermedades Desmielinizantes es_ES
dc.subject Demyelinating Diseases es_ES
dc.title Microglia-derived extracellular vesicles in homeostasis and demyelination/remyelination processes es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.description.fil Fil: Correale, Jorge. Fleni. Departamento de Neurología. Servicio de Neuroinmunología y Enfermedades Desmielinizantes; Argentina.
dc.relation.ispartofCOUNTRY Inglaterra
dc.relation.ispartofCITY Oxford
dc.relation.ispartofTITLE Journal of neurochemistry
dc.relation.ispartofISSN 1471-4159
dc.type.snrd info:ar-repo/semantics/artículo es_ES


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