Repositorio Dspace

Listar Neurología Cognitiva.artículos por autor "Bateman, Randall J."

Listar Neurología Cognitiva.artículos por autor "Bateman, Randall J."

Ordenar por:Orden:Resultados:

  • Accelerated longitudinal changes and ordering of Alzheimer disease biomarkers across the adult lifespan 
    Luo, Jingqin; Agboola, Folasade; Grant, Elizabeth; Morris, John C.; Masters, Colin L.; Albert, Marilyn S.; Johnson, Sterling C.; McDade, Eric; Fagan, Anne M.; Benzinger, Tammie L.S.; Hassenstab, Jason; Bateman, Randall J.; Perrin, Richard J.; Wang, Guoqiao; Li, Yan; Gordon, Brian A.; Cruchaga, Carlos; Day, Gregory S.; Allegri, Ricardo Francisco; Dominantly Inherited Alzheimer Network (Oxford University Press, 2022-08-04)
    The temporal evolutions and relative orderings of Alzheimer disease biomarkers, including CSF amyloid-β42 (Aβ42), Aβ40, total tau (Tau) and phosphorylated tau181 (pTau181), standardized uptake value ratio (SUVR) from the ...
  • Association of Longitudinal Changes in Cerebrospinal Fluid Total Tau and Phosphorylated Tau 181 and Brain Atrophy With Disease Progression in Patients With Alzheimer Disease 
    Llibre Guerra, Jorge J.; Li, H; Schindler, Suzanne E.; Gordon, Brian A.; Fagan, Anne M.; Morris, John C.; Benzinger, Tammie L.S.; Hassenstab, Jason; Wang, Guoquiao; Allegri, Ricardo Francisco; Berman, Sarah B.; Chhatwal, Jasmeer P.; Farlow, Martin R.; Holtzman, David M.; Jucker, Mathias; Levin, Johannes; Noble, James M.; Salloway, Stephen; Schofield, Peter R.; Karch, Celeste M.; Fox, Nick C.; Xiong, Chengjie; Bateman, Randall J.; McDade, Eric (American Medical Association, 2019-12-02)
    The amyloid/tau/neurodegeneration (A/T/N) framework uses cerebrospinal fluid (CSF) levels of total tau (tTau) as a marker of neurodegeneration and CSF levels of phosphorylated tau 181 (pTau181) as a marker of tau tangles. ...
  • Awareness of genetic risk in the Dominantly Inherited Alzheimer Network (DIAN) 
    Aschenbrenner, Andrew J.; James, Bryan D.; McDade, Eric; Wang, Guoquiao; Lim, Yen Ying; Benzinger, Tammie L.S.; Cruchaga, Carlos; Goate, Alison M.; Xiong, Chengjie; Perrin, Richard J.; Buckles, Virginia; Allegri, Ricardo Francisco; Berman, Sarah B.; Chhatwal, Jasmeer P.; Fagan, Anne M.; Farlow, Martin R.; O’Connor, Antoinette; Ghetti, Bernardino; Graff-Radford, Neill R.; Goldman, Jill; Gräber, Susanne; Karch, Celeste M.; Lee, Jae-Hong; Levin, Johannes; Martins, Ralph N.; Masters, Colin L.; Mori, Hiroshi; Noble, James M.; Salloway, Stephen; Schofield, Peter R.; Morris, John C.; Bateman, Randall J.; Hassenstab, Jason; Dominantly Inherited Alzheimer Network; Dominantly Inherited Alzheimer Network (Wiley, 2020-06)
    Introduction: Although some members of families with autosomal dominant Alzheimer's disease mutations learn their mutation status, most do not. How knowledge of mutation status affects clinical disease progression is ...
  • Biphasic cortical macro- and microstructural changes in autosomal dominant Alzheimer's disease 
    Montal, Victor; Vilaplana, Eduard; Pegueroles, Jordi; Bejanin, Alexandre; Alcolea, Daniel; Carmona-Iragui, María; Clarimón, Jordi; Levin, Johannes; Cruchaga, Carlos; Graff-Radford, Neill R.; Noble, James M.; Lee, Jae-Hong; Allegri, Ricardo Francisco; Karch, Celeste M.; Laske, Christoph; Schofield, Peter R.; Salloway, Stephen; Ances, Beau M.; Benzinger, Tammie L.S.; McDade, Eric; Bateman, Randall J.; Blesa, Rafael; Sánchez-Valle, Raquel; Lleó, Alberto; Fortea, Juan; Dominantly Inherited Alzheimer Network (John Wiley & Sons, 2020-11-16)
    Methods: In this study we tested this model fitting linear versus quadratic trajectories and computed the timing of the inflection points vertexwise of cortical thickness and cortical diffusivity-a novel marker of cortical ...
  • Bundle-specific associations between white matter microstructure and Ab and tau pathology in preclinical Alzheimer’s disease 
    Pichet Binette, Alexa; Theaud, Guillaume; Rheault, François; Roy, Maggie; Collins, D. Louis; Levin, Johannes; Mori, Hiroshi; Lee, Hae Hong; Rhys Farlow, Martin; Schofield, Peter R.; Chhatwal, Jasmeer P.; Masters, Colin L.; Benzinger, Tammie L.S.; Morris, John C.; Bateman, Randall J.; Breitner, John C.S.; Poirier, Judes; Allegri, Ricardo Francisco; DIAN Study Group; PREVENT-AD Research Group (eLife Sciences Publications, 2021-05-13)
    Beta-amyloid (Ab) and tau proteins, the pathological hallmarks of Alzheimer’s disease (AD), are believed to spread through connected regions of the brain. Combining diffusion imaging and positron emission tomography, we ...
  • Clinical, pathophysiological and genetic features of motor symptoms in autosomal dominant Alzheimer’s disease 
    Vöglein, Jonathan; Paumier, Katrina; Jucker, Mathias; Preische, Oliver; McDade, Eric; Hassenstab, Jason; Benzinger, Tammie L.S.; Noble, James M.; Berman, Sarah B.; Graff-Radford, Neill R.; Ghetti, Bernardino; Farlow, Martin R.; Chhatwal, Jasmeer P.; Salloway, Stephen; Xiong, Chengjie; Karch, Celeste M.; Cairns, Nigel; Mori, Hiroshi; Schofield, Peter R.; Masters, Colin L.; Goate, Alison M.; Buckles, Virginia; Fox, Nick C.; Rossor, Martin N.; Chrem Méndez, Patricio Alexis; Allegri, Ricardo Francisco; Ringman, John M.; Höglinger, Günter; Steiner, Harald; Dieterich, Marianne; Haass, Christian; Laske, Christoph; Morris, John C.; Bateman, Randall J.; Danek, Adrian; Levin, Johannes; Dominantly Inherited Alzheimer Network (Oxford, 2019-03-20)
    Owing to an early and marked deposition of amyloid-β in the basal ganglia, autosomal dominant Alzheimer’s disease could distinctly involve motor symptoms. Therefore, we aimed to assess the prevalence and characteristics ...
  • Comparing cortical signatures of atrophy between late-onset and autosomal dominant Alzheimer disease 
    Allegri, Ricardo Francisco; Dincer, Aylin; Gordon, Brian A.; Hari-Raj, Amrita; Keefe, Sarah J.; Flores, Shaney; McKay, Nicole S.; Paulick, Angela M.; Shady Lewis, Kristine E.; Feldman, Rebecca L.; Hornbeck, Russ C.; Ances, Beau M.; Berman, Sarah B.; Brickman, Adam M.; Brooks, William S.; Cash, David M.; Chhatwal, Jasmeer P.; Farlow, Martin R.; La Fougère, Christian; Fox, Nick C.; Fulham, Michael J.; Jack Jr, Clifford R.; Joseph-Mathurin, Nelly; Karch, Celeste M.; Lee, Athene; Levin, Johannes; Masters, Colin L.; McDade, Eric; Oh, Hwamee; Perrin, Richard J.; Raji, Cyrus; Salloway, Stephen; Schofield, Peter R.; Su, Yi; Villemagne, Victor L.; Wang, Qing; Weiner, Michael W.; Xiong, Chengjie; Yakushev, Igor; Morris, John C.; Bateman, Randall J.; Benzinger, Tammie L.S.; Dominantly Inherited Alzheimer Network (Elsevier, 2020-11-05)
    Defining a signature of cortical regions of interest preferentially affected by Alzheimer disease (AD) pathology may offer improved sensitivity to early AD compared to hippocampal volume or mesial temporal lobe alone. Since ...
  • Comparison of CSF biomarkers in Down syndrome and autosomal dominant Alzheimer's disease: a cross-sectional study 
    Fagan, Anne M.; Henson, Rachel L.; Li, Yan; Boerwinkle, Anna H.; Xiong, Chengjie; Bateman, Randall J.; Goate, Alison M.; Ances, Beau M.; Doran, Eric; Christian, Bradley T.; Lai, Florence; Rosas, H. Diana; Schupf, Nicole; Krinsky-McHale, Sharon; Silverman, Wayne; Lee, Joseph H.; Klunk, William E.; Handen, Benjamin L.; Allegri, Ricardo Francisco; Alzheimer's Biomarker Consortium-Down Syndrome; Dominantly Inherited Alzheimer Network (Elsevier, 2021-08)
    Background Due to trisomy of chromosome 21 and the resultant extra copy of the amyloid precursor protein gene, nearly all adults with Down syndrome develop Alzheimer's disease pathology by the age of 40 years and are at ...
  • Cross-sectional and longitudinal comparisons of biomarkers and cognition among asymptomatic middle-aged individuals with a parental history of either autosomal dominant or late-onset Alzheimer's disease 
    Xiong, Chengjie; McCue, Lena M.; Buckles, Virginia; Grant, Elizabeth; Agboola, Folasade; Coble, Dean; Bateman, Randall J.; Fagan, Anne M.; Benzinger, Tammie L.S.; Hassenstab, Jason; Schindler, Suzanne E.; McDade, Eric; Moulder, Krista L.; Gordon, Brian A.; Cruchaga, Carlos; Day, Gregory S.; Ikeuchi, Takeshi; Suzuki, Kazushi; Allegri, Ricardo Francisco; Dominantly Inherited Alzheimer Network (Wiley, 2023-01-14)
    Background: Comparisons of late-onset Alzheimer's disease (LOAD) and autosomal dominant AD (ADAD) are confounded by age. Methods: We compared biomarkers from cerebrospinal fluid (CSF), magnetic resonance imaging, and ...
  • Different rates of cognitive decline in autosomal dominant and late-onset Alzheimer disease 
    Buckles, Virginia; Xiong, Chengjie; Bateman, Randall J.; Hassenstab, Jason; Allegri, Ricardo Francisco; Berman, Sarah B.; Chhatwal, Jasmeer P.; Danek, Adrian; Fagan, Anne M.; Ghetti, Bernardino; Goate, Alison M.; Graff-Radford, Neill R.; Jucker, Mathias; Levin, Johannes; Marcus, Daniel S.; Masters, Colin L.; McCue, Lena M.; McDade, Eric; Mori, Hiroshi; Moulder, Krista L. (John Wiley & Sons, 2021-12-02)
    As prevention trials advance with autosomal dominant Alzheimer disease (ADAD) participants, understanding the similarities and differences between ADAD and "sporadic" late-onset AD (LOAD) is critical to determine ...
  • Multimodal brain age estimates relate to Alzheimer disease biomarkers and cognition in early stages: a cross-sectional observational study 
    Millar, Peter R.; Gordon, Brian A.; Luckett, Patrick H.; Benzinger, Tammie L.S.; Cruchaga, Carlos; Fagan, Anne M.; Hassenstab, Jason; Perrin, Richard J.; Schindler, Suzanne E.; Allegri, Ricardo Francisco; Day, Gregory S.; Farlow, Martin R.; Mori, Hiroshi; Nübling, Georg; Dominantly Inherited Alzheimer Network; Bateman, Randall J.; Morris, John C.; Ances, Beau M. (eLife Sciences Publications, 2023-01-06)
    Background: Estimates of 'brain-predicted age' quantify apparent brain age compared to normative trajectories of neuroimaging features. The brain age gap (BAG) between predicted and chronological age is elevated in symptomatic ...
  • Parenchymal border macrophages regulate the flow dynamics of the cerebrospinal fluid 
    Drieu, Antoine; Du, Siling; Storck, Steffen E.; Rustenhoven, Justin; Papadopoulos, Zachary; Dykstra, Taitea; Zhong, Fenghe; Kim, Kyungdeok; Blackburn, Susan; Mamuladze, Tornike; Harari, Oscar; Karch, Celeste M.; Bateman, Randall J.; Perrin, Richard J.; Farlow, Martin R.; Chhatwal, Jasmeer; Dominantly Inherited Alzheimer Network; Hu, Song; Randolph, Gwendalyn J.; Allegri, Ricardo Francisco (Nature Publishing Group, 2022-11)
    Macrophages are important players in the maintenance of tissue homeostasis1. Perivascular and leptomeningeal macrophages reside near the central nervous system (CNS) parenchyma2, and their role in CNS physiology has not ...
  • Pattern and degree of individual brain atrophy predicts dementia onset in dominantly inherited Alzheimer's disease 
    Keret, Ophir; Staffaroni, Adam M.; Ringman, John M.; Cobigo, Yann; Goh, Sheng-Yang M.; Wolf, Amy; Allen, Isabel Elaine; Salloway, Stephen; Chhatwal, Jasmeer P.; Brickman, Adam M.; Reyes-Dumeyer, Dolly; Bateman, Randall J.; Benzinger, Tammie L.S.; Morris, John C.; Ances, Beau M.; Joseph-Mathurin, Nelly; Perrin, Richard J.; Gordon, Brian A.; Allegri, Ricardo Francisco; Chrem Méndez, Patricio Alexis (Wiley, 2021-07-05)
    Introduction Asymptomatic and mildly symptomatic dominantly inherited Alzheimer's disease mutation carriers (DIAD-MC) are ideal candidates for preventative treatment trials aimed at delaying or preventing dementia onset. ...
  • Predicting brain age from functional connectivity in symptomatic and preclinical Alzheimer disease 
    Millar, Peter R.; Luckett, Patrick H.; Gordon, Brian A.; Benzinger, Tammie L.S.; Schindler, Suzanne E.; Fagan, Anne M.; Cruchaga, Carlos; Bateman, Randall J.; Allegri, Ricardo Francisco; Jucker, Mathias; Lee, Jae-Hong; Mori, Hiroshi; Salloway, Stephen; Igor, Yakushev; Morris, John C.; Ances, Beau M.; Dominantly Inherited Alzheimer Network (Academic Press, 2022-08-01)
    "Brain-predicted age" quantifies apparent brain age compared to normative neuroimaging trajectories. Advanced brain-predicted age has been well established in symptomatic Alzheimer disease (AD), but is underexplored in ...
  • A soluble phosphorylated tau signature links tau, amyloid and the evolution of stages of dominantly inherited Alzheimer's disease 
    Barthélemy, Nicolas R.; Li, Yan; Joseph-Mathurin, Nelly; Gordon, Brian A.; Hassenstab, Jason; Benzinger, Tammie L.S.; Buckles, Virginia; Fagan, Anne M.; Perrin, Richard J.; Goate, Alison M.; Morris, John C.; Karch, Celeste M.; Xiong, Chengjie; Allegri, Ricardo Francisco; Chrem Méndez, Patricio Alexis; Berman, Sarah B.; Ikeuchi, Takeshi; Mori, Hiroshi; Shimada, Hiroyuki; Shoji, Mikio; Suzuki, Kazushi; Noble, James M.; Farlow, Martin R.; Chhatwal, Jasmeer P.; Graff-Radford, Neill R.; Salloway, Stephen; Schofield, Peter R.; Masters, Colin L.; Martins, Ralph N.; O’Connor, Antoinette; Fox, Nick C.; Levin, Johannes; Jucker, Mathias; Gabelle, Audrey; Lehmann, Sylvain; Sato, Chihiro; Bateman, Randall J.; McDade, Eric; Dominantly Inherited Alzheimer Network (Nature, 2020-03)
    Development of tau-based therapies for Alzheimer's disease requires an understanding of the timing of disease-related changes in tau. We quantified the phosphorylation state at multiple sites of the tau protein in cerebrospinal ...

Buscar en DSpace


Búsqueda avanzada

Listar

Mi cuenta