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Accelerated longitudinal changes and ordering of Alzheimer disease biomarkers across the adult lifespan

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dc.contributor.author Luo, Jingqin
dc.contributor.author Agboola, Folasade
dc.contributor.author Grant, Elizabeth
dc.contributor.author Morris, John C.
dc.contributor.author Masters, Colin L.
dc.contributor.author Albert, Marilyn S.
dc.contributor.author Johnson, Sterling C.
dc.contributor.author McDade, Eric
dc.contributor.author Fagan, Anne M.
dc.contributor.author Benzinger, Tammie L.S.
dc.contributor.author Hassenstab, Jason
dc.contributor.author Bateman, Randall J.
dc.contributor.author Perrin, Richard J.
dc.contributor.author Wang, Guoqiao
dc.contributor.author Li, Yan
dc.contributor.author Gordon, Brian A.
dc.contributor.author Cruchaga, Carlos
dc.contributor.author Day, Gregory S.
dc.contributor.author Allegri, Ricardo Francisco
dc.contributor.author Dominantly Inherited Alzheimer Network
dc.date.accessioned 2022-10-18T11:38:32Z
dc.date.available 2022-10-18T11:38:32Z
dc.date.issued 2022-08-04
dc.identifier.citation Luo J, Agboola F, Grant E, Morris JC, Masters CL, Albert MS, Johnson SC, McDade EM, Fagan AM, Benzinger TLS, Hassenstab J, Bateman RJ, Perrin RJ, Wang G, Li Y, Gordon BA, Cruchaga C, Day GS, Levin J, Vöglein J, Ikeuchi T, Suzuki K, Allegri RF, Xiong C; Dominantly Inherited Alzheimer Network (DIAN). Accelerated longitudinal changes and ordering of Alzheimer disease biomarkers across the adult lifespan. Brain. 2022 Aug 4:awac238. doi: 10.1093/brain/awac238. es_ES
dc.identifier.uri https://repositorio.fleni.org.ar/xmlui/handle/123456789/689
dc.identifier.uri https://doi.org/10.1093/brain/awac238
dc.description.abstract The temporal evolutions and relative orderings of Alzheimer disease biomarkers, including CSF amyloid-β42 (Aβ42), Aβ40, total tau (Tau) and phosphorylated tau181 (pTau181), standardized uptake value ratio (SUVR) from the molecular imaging of cerebral fibrillar amyloid-β with PET using the 11C-Pittsburgh Compound-B (PiB), MRI-based hippocampal volume and cortical thickness and cognition have been hypothesized but not yet fully tested with longitudinal data for all major biomarker modalities among cognitively normal individuals across the adult lifespan starting from 18 years. By leveraging a large harmonized database from 8 biomarker studies with longitudinal data from 2609 participants in cognition, 873 in MRI biomarkers, 519 in PET PiB imaging and 475 in CSF biomarkers for a median follow-up of 5-6 years, we estimated the longitudinal trajectories of all major Alzheimer disease biomarkers as functions of baseline age that spanned from 18 to 103 years, located the baseline age window at which the longitudinal rates of change accelerated and further examined possible modifying effects of apolipoprotein E (APOE) genotype. We observed that participants 18-45 years at baseline exhibited learning effects on cognition and unexpected directions of change on CSF and PiB biomarkers. The earliest acceleration of longitudinal change occurred for CSF Aβ42 and Aβ42/Aβ40 ratio (with an increase) and for Tau, and pTau181 (with a decrease) at the next baseline age interval of 45-50 years, followed by an accelerated increase for PiB SUVR at the baseline age of 50-55 years and an accelerated decrease for hippocampal volume at the baseline age of 55-60 years and finally by an accelerated decline for cortical thickness and cognition at the baseline age of 65-70 years. Another acceleration in the rate of change occurred at the baseline age of 65-70 years for Aβ42/Aβ40 ratio, Tau, pTau181, PiB SUVR and hippocampal volume. Accelerated declines in hippocampal volume and cognition continued after 70 years. For participants 18-45 years at baseline, significant increases in Aβ42 and Aβ42/Aβ40 ratio and decreases in PiB SUVR occurred in APOE ɛ4 non-carriers but not carriers. After age 45 years, APOE ɛ4 carriers had greater magnitudes than non-carriers in the rates of change for all CSF biomarkers, PiB SUVR and cognition. Our results characterize the temporal evolutions and relative orderings of Alzheimer disease biomarkers across the adult lifespan and the modification effect of APOE ɛ4. These findings may better inform the design of prevention trials on Alzheimer disease. es_ES
dc.language.iso eng es_ES
dc.publisher Oxford University Press es_ES
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by/2.5/ar/
dc.subject Alzheimer Disease es_ES
dc.subject Enfermedad de Alzheimer es_ES
dc.subject Biomarkers es_ES
dc.subject Biomarcadores es_ES
dc.title Accelerated longitudinal changes and ordering of Alzheimer disease biomarkers across the adult lifespan es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.type info:eu-repo/semantics/publishedVersion
dc.description.fil Fil: Allegri, Ricardo Francisco. Fleni. Departamento de Neurología. Servicio de Neurología Cognitiva, Neuropsicología y Neuropsiquiatría. Centro de Memoria y Envejecimiento; Argentina.
dc.description.fil Fil: Luo, Jingqin. Washington University School of Medicine. Department of Surgery. Division of Public Health Sciences; Estados Unidos. Washington University School of Medicine. Siteman Cancer Center Biostatistics Core; Estados Unidos. Washington University School of Medicine. Division of Biostatistics; Estados Unidos.
dc.description.fil Fil: Agboola, Folasade. Washington University School of Medicine. Division of Biostatistics; Estados Unidos. Washington University School of Medicine. Knight Alzheimer Disease Research Center; Estados Unidos.
dc.description.fil Fil: Grant, Elizabeth. Washington University School of Medicine. Knight Alzheimer Disease Research Center; Estados Unidos. Washington University School of Medicine. Division of Biostatistics; Estados Unidos.
dc.description.fil Fil: Morris, John C. Washington University School of Medicine. Knight Alzheimer Disease Research Center; Estados Unidos. Washington University School of Medicine. Department of Neurology; Estados Unidos. Washington University School of Medicine. Departments of Pathology and Immunology; Estados Unidos.
dc.description.fil Fil: Masters, Colin L. University of Melbourne. The Florey Institute of Neuroscience and Mental Health; Estados Unidos.
dc.description.fil Fil: Albert, Marilyn S. Johns Hopkins University School of Medicine, Baltimore. Department of Neurology; Estados Unidos.
dc.description.fil Fil: Johnson, Sterling C. University of Wisconsin-Madison School of Medicine and Public Health. Wisconsin Alzheimer's Institute and Alzheimer's Disease Research Center; Estados Unidos. Middleton Veterans Memorial Hospital. Geriatric Research Education and Clinical Center; Estados Unidos.
dc.description.fil Fil: McDade, Eric. Washington University School of Medicine. Department of Neurology; Estados Unidos.
dc.description.fil Fil: Fagan, Anne M. Washington University School of Medicine. Knight Alzheimer Disease Research Center; Estados Unidos. Washington University School of Medicine. Department of Neurology; Estados Unidos.
dc.description.fil Fil: Benzinger, Tammie L.S. Washington University School of Medicine. Knight Alzheimer Disease Research Center; Estados Unidos. Washington University School of Medicine. Department of Radiology; Estados Unidos.
dc.description.fil Fil: Hassenstab, Jason. Washington University School of Medicine. Knight Alzheimer Disease Research Center; Estados Unidos. Washington University School of Medicine. Department of Neurology; Estados Unidos.
dc.description.fil Fil: Bateman, Randall J. Washington University School of Medicine. Knight Alzheimer Disease Research Center; Estados Unidos. Washington University School of Medicine. Department of Neurology; Estados Unidos.
dc.description.fil Fil: Perrin, Richard J. Washington University School of Medicine. Knight Alzheimer Disease Research Center; Estados Unidos. Washington University School of Medicine. Department of Neurology; Estados Unidos. Washington University School of Medicine. Departments of Pathology and Immunology; Estados Unidos.
dc.description.fil Fil: Wang, Guoqiao. Washington University School of Medicine. Knight Alzheimer Disease Research Center; Estados Unidos. Washington University School of Medicine. Division of Biostatistics; Estados Unidos.
dc.description.fil Fil: Li, Yan. Washington University School of Medicine. Knight Alzheimer Disease Research Center; Estados Unidos. Washington University School of Medicine. Department of Neurology; Estados Unidos.
dc.description.fil Fil: Gordon, Brian A. Washington University School of Medicine. Knight Alzheimer Disease Research Center; Estados Unidos. Middleton Veterans Memorial Hospital. Geriatric Research Education and Clinical Center; Estados Unidos.
dc.description.fil Fil: Cruchaga, Carlos. Washington University School of Medicine. Knight Alzheimer Disease Research Center; Estados Unidos. Washington University School of Medicine. Department of Radiology; Estados Unidos.
dc.description.fil Fil: Day, Gregory S. Mayo Clinic. Department of Neurology; Estados Unidos.
dc.relation.ispartofPAGINATION awac238
dc.relation.ispartofCOUNTRY Inglaterra
dc.relation.ispartofCITY Londres
dc.relation.ispartofTITLE Brain : a journal of neurology
dc.relation.ispartofISSN 1460-2156
dc.type.snrd info:ar-repo/semantics/artículo es_ES


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