Generation of a gene-corrected human isogenic iPSC line from an Alzheimer's disease iPSC line carrying the PSEN1 H163R mutation

Hernández, Damián; Morgan Schlicht, Stephanie; Clarke, Jordan Elli; Daniszewski, Maciej; Karch, Celeste M.; Dominantly Inherited Alzheimer Network; Goate, Alison M.; Pébay, Alice; Allegri, Ricardo Francisco

Generation of a gene-corrected human isogenic iPSC line from an Alzheimer's disease iPSC line carrying the PSEN1 H163R mutation

Hernández, Damián; Morgan Schlicht, Stephanie; Clarke, Jordan Elli; Daniszewski, Maciej; Karch, Celeste M.; Dominantly Inherited Alzheimer Network; Goate, Alison M.; Pébay, Alice; Allegri, Ricardo Francisco

URI: https://doi.org/10.1016/j.scr.2024.103495
https://repositorio.fleni.org.ar/xmlui/handle/123456789/1198

Date: 2024-09

Abstract:

We report the generation of a gene-edited human induced pluripotent stem cell (iPSC) line from an Alzheimer's disease patient-derived iPSC line harbouring the PSEN1 H163R mutation. This line demonstrates pluripotent stem cell morphology, expression of pluripotency markers, and maintains a normal karyotype.

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