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dc.contributor.author | Marrodán, Mariano | |
dc.contributor.author | Bensi, Catalina | |
dc.contributor.author | Pappolla, Agustín | |
dc.contributor.author | Rojas, Juan Ignacio | |
dc.contributor.author | Gaitán, María Inés | |
dc.contributor.author | Ysrraelit, María Célica | |
dc.contributor.author | Negrotto, Laura | |
dc.contributor.author | Fiol, Marcela Paula | |
dc.contributor.author | Patrucco, Liliana | |
dc.contributor.author | Cristiano, Edgardo | |
dc.contributor.author | Farez, Mauricio Franco | |
dc.contributor.author | Correale, Jorge | |
dc.date.accessioned | 2020-03-13T18:18:53Z | |
dc.date.available | 2020-03-13T18:18:53Z | |
dc.date.issued | 2019-12-14 | |
dc.identifier.citation | Marrodan, M., Bensi, C., Pappolla, A., Rojas, J.I., Gaitán, M.I., Ysrraelit, M.C., Negrotto, L., Fiol, M.P., Patrucco, L., Cristiano, E., Farez, M.F., Correale, J. Disease activity impacts disability progression in primary progressive multiple sclerosis. Mult Scler Relat Disord. 2019 Dec 14;39:101892. doi: 10.1016/j.msard.2019.101892 | en_US |
dc.identifier.uri | https://doi.org/10.1016/j.msard.2019.101892 | |
dc.identifier.uri | https://repositorio.fleni.org.ar/handle/123456789/200 | |
dc.description.abstract | Background Although solid information on the natural history of primary progressive multiple sclerosis (PPMS) is available, evidence regarding impact of disease activity on PPMS progression remains controversial. Objective To describe the clinical characteristics, presence or absence of MRI activity, and natural history of a PPMS cohort from two referral centers in Argentina and assess whether clinical and/or radiological disease activity correlated with disability worsening. Methods Retrospective study conducted at two MS clinics in Buenos Aires, Argentina, through comparative analysis of patients with and without evidence of disease activity. Results Clinical and/or radiologic activity was presented in 56 (31%) of 178 patients. When stratified by age at onset, we found that for every 10 years of increase in age at onset, risk of reaching EDSS scores of 4 and 6 increased by 26% and 31%, respectively (EDSS 4: HR 1.26, CI 95%: 1.06–1.50; EDSS 6: HR 1.31, CI 95%: 1.06–1.62). Patients who presented clinical exacerbations reached EDSS scores of 6, 7 and 8 faster than those without associated exacerbations (p = 0.009, p = 0.016 and p = 0.001, respectively). Likewise, patients who presented gadolinium-enhancing lesions during the course of disease reached EDSS scores of 7 earlier (p = 0.002). Conclusion Older age at onset and presence of clinical and/or radiological disease activity correlated with accelerated disability progression in this cohort of PPMS patients. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Elsevier | en_US |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by/2.5/ar/ | |
dc.subject | Multiple Sclerosis | en_US |
dc.subject | Esclerosis Múltiple | en_US |
dc.subject | Disability Evaluation | en_US |
dc.subject | Evaluación de la Discapacidad | en_US |
dc.title | Disease activity impacts disability progression in primary progressive multiple sclerosis | en_US |
dc.type | info:eu-repo/semantics/publishedVersion | |
dc.type | info:eu-repo/semantics/article | en_US |
dc.description.fil | Fil: Marrodán, Mariano. Fleni. Departamento de Neurología. Servicio de Neuroinmunología y Enfermedades Desmielinizantes; Argentina. | |
dc.description.fil | Fil: Bensi, Catalina. Fleni. Departamento de Neurología; Argentina. | |
dc.description.fil | Fil: Pappolla, Agustín. Hospital Italiano; Argentina. | |
dc.description.fil | Fil: Rojas, Juan Ignacio. Hospital Italiano; Argentina. | |
dc.description.fil | Fil: Gaitán, María Inés. Fleni. Departamento de Neurología. Servicio de Neuroinmunología y Enfermedades Desmielinizantes; Argentina. | |
dc.description.fil | Fil: Ysrraelit, María Célica. Fleni. Departamento de Neurología; Argentina. | |
dc.description.fil | Fil: Negrotto, Laura. Fleni. Departamento de Neurología. Servicio de Neuroinmunología y Enfermedades Desmielinizantes; Argentina. | |
dc.description.fil | Fil: Fiol, Marcela Paula. Fleni. Departamento de Neurología. Servicio de Neuroinmunología y Enfermedades Desmielinizantes; Argentina. | |
dc.description.fil | Fil: Patrucco, Liliana. Hospital Italiano; Argentina. | |
dc.description.fil | Fil: Cristiano, Edgardo. Centro de Esclerosis Múltiple de Buenos Aires; Argentina. | |
dc.description.fil | Fil: Farez, Mauricio Franco. Fil: Farez, Mauricio Franco. Fleni. Centro para la Investigación de Enfermedades Neuroinmunológicas; Argentina. | |
dc.description.fil | Fil: Correale, Jorge. Fleni. Departamento de Neurología. Servicio de Neuroinmunología y Enfermedades Desmielinizantes; Argentina. | |
dc.relation.ispartofVOLUME | 39 | |
dc.relation.ispartofNUMBER | 101892 | |
dc.relation.ispartofCOUNTRY | Países Bajos | |
dc.relation.ispartofCITY | Amsterdam | |
dc.relation.ispartofTITLE | Multiple sclerosis and related disorders | |
dc.relation.ispartofISSN | 2211-0356 | |
dc.type.snrd | info:ar-repo/semantics/artículo | es_ES |