Neurología Cognitiva: Recent submissions

  • Redes neuronales y funcionamiento cognitivo en la fragilidad: una revisión sistemática de la literatura 
    Lastre Meza, Karina; Allegri, Ricardo Francisco; Barceló Martínez, Ernesto (Fundación Universitaria Católica del Norte, 2025-09-06)
    La fragilidad se presenta como un factor de riesgo clave para la disfunción cognitiva en adultos mayores. El propósito de la revisión sistemática es sintetizar la evidencia disponible en los últimos 11 años sobre la relación ...
  • The relationship of soluble tau species with Alzheimer's disease amyloid plaque removal and tau pathology 
    McDade, Eric; Barthélemy, Nicolas R.; Wang, Guoqiao; Li, Yan; Cao, Yuchen; Gordon, Brian; Benzinger, Tammie L. S.; Clifford, David; Goate, Alison M.; Renton, Alan E.; Hassenstab, Jason; Llibre-Guerra, Jorge J.; Perrin, Richard J.; Xiong, Chengjie; Cruchaga, Carlos; Mummery, Catherine J.; Berman, Sarah B.; Lah, James; Chrem Méndez, Patricio Alexis; DIAN‐TU Study Team and DIAN Obs Team (Wiley, 2025-09-23)
    Background: Tau-derived cerebrospinal fluid (CSF) biomarkers correlate with amyloid-beta (Aβ) plaques or tau tangles in Alzheimer's disease (AD). This study assessed the effects of long-term anti-Aβ antibodies on amyloid ...
  • New landscape of the diagnosis of Alzheimer's disease 
    Frisoni, Giovanni B.; Hansson, Oskar; Nichols, Emma; Garibotto, Valentina; Schindler, Suzanne E.; van der Flier, Wiesje M.; Jessen, Frank; Villain, Nicolas; Arenaza-Urquijo, Eider M.; Crivelli, Lucia; Fortea, Juan; Grinberg, Lea T.; Ismail, Zahinoor; Minoshima, Satoshi; Ossenkoppele, Rik; Zetterberg, Henrik; Petersen, Ronald C.; Dubois, Bruno (Elsevier, 2025-09-22)
    Alzheimer's disease involves a drastic departure from the cognitive, functional, and behavioural trajectory of normal ageing, and is both a dreaded and highly prevalent cause of disability to individuals, and a leading ...
  • Cognitive and physical activities are associated with cognitive resilience in a memory clinic cohort 
    Bocancea, Diana I.; van Loenhoud, Anna C.; Kuijper, Bart; Calandri, Ismael Luis; Groot, Colin; Venkatraghavan, Vikram; de Boer, Casper; Ten Kate, Mara; Trieu, Calvin; Teunissen, Charlotte E.; van de Giessen, Elsmarieke; Leeuwis, Anna E.; Schlueter, Lisa-Marie; van Harten, Argonde C.; Pijnenburg, Yolande A. L.; Barkhof, Frederik; van der Flier, Wiesje M.; Ossenkoppele, Rik (Oxford University Press, 2025-09-06)
    Lifestyle factors such as participation in cognitively stimulating activities and physical activity are hypothesized to foster neural connections and enhance resilience, thereby attenuating cognitive loss in the context ...
  • Cross-Sectional FDG in Down Syndrome and Autosomal Dominant Alzheimer's Disease 
    Abdelmoity, Omar; Wisch, Julie K.; Kennedy, James T.; Goyal, Manu; Vlassenko, Andrei; Flores, Shaney; Handen, Benjamin L.; Head, Elizabeth; Keator, David; Rafii, Michael S.; Lao, Patrick; Lai, Florence; Rosas, H. Diana; Hartley, Sigan L.; Zaman, Shahid; Brickman, Adam M.; Tudorascu, Dana; Lee, Joseph H.; Allegri, Ricardo Francisco; Alzheimer's Biomarker Consortium‐Down Syndrome and the Dominantly Inherited Alzheimer Network (Wiley, 2025-09-22)
    Objectives: Directly compare the brain glucose patterns seen with [F-18] fluorodeoxyglucose (FDG) positron emission tomography (PET) between 2 genetically determined forms of Alzheimer's disease: Down syndrome (DS) and ...
  • Infusiones de ketamina a dosis subanestésicas en la depresión mayor resistente al tratamiento: protocolo de aplicación en un hospital público de Argentina 
    Dines, Micaela; Bulacia, Adriana; Bamondez, Paloma; Vega, Irene Luis; Montenegro, Micaela; Díaz, Pablo Germán; Oyhamburu, Paula; Ramos, Ana Laura; Ambrosio, Florencia; Vázquez, Gustavo; Pereyra, Monica; Pereyra, Hugo; Cichello, Cynthia; Ríos Merino, Laura Natalia (Polemos, 2025-07-10)
    La depresión mayor resistente al tratamiento (DMRT) representa un desafío significativo en psiquiatría, dada la limitada respuesta a las terapias convencionales. La ketamina endovenosa (EV) a dosis subanestésicas ha emergido ...
  • Immunohistochemical evaluation of a trial of gantenerumab or solanezumab in dominantly inherited Alzheimer disease 
    Chen, Charles D.; Franklin, Erin E.; Li, Yan; Joseph-Mathurin, Nelly; Burns, Aime L.; Hobbs, Diana A.; McCullough, Austin A.; Schultz, Stephanie A.; Xion, Chengjie; Wang, Guoqiao; Masellis, Mario; Robin Hsiung, Ging-Yuek; Gauthier, Serge; Berman, Sarah B.; Roberson, Erik D.; Honig, Lawrence S.; Clarnette, Roger; Allegri, Ricardo Francisco; DIAN-TU Study Team; DIAN-Obs Study Team (Springer Verlag, 2025-06-03)
    Clinical trials of anti-amyloid-β (Aβ) monoclonal antibodies in Alzheimer disease (AD) infer target engagement from Aβ positron emission tomography (PET) and/or fluid biomarkers such as cerebrospinal fluid (CSF) Aβ42/40. ...
  • Dementia research in low-income and middle-income countries - a view from Latin America 
    Allegri, Ricardo Francisco (Nature, 2025-07-29)
    Dementia research, and research in general, has historically been scarce in low-income and middle-income countries (LMICs). However, a high burden of dementia is faced by these regions, with a higher prevalence compared ...
  • Behavioral variant frontotemporal dementia (bvFTD): PET biomarker characterization of metabolism (18F-FDG), amyloid (11C-PIB) and tau (18F-AV1451) and its clinical correlate - analysis of a cohort from Argentina 
    Magrath Guimet, Nahuel; Falasco, Germán; Urrutia, Leandro; Herrera, Julio José; Chrem Méndez, Patricio Alexis; Surace, Ezequiel Ignacio; Allegri, Ricardo Francisco; Vázquez, Silvia; Bagnati, Pablo Miguel; Bérgamo, Yanina (Wiley, 2025-04)
    Introduction: Imaging biomarkers are fundamental in diagnosing neurodegenerative diseases, but their use in FTD remains limited. This study examines PET biomarkers in Argentine bvFTD patients. Methods: We studied a ...
  • Understanding barriers and optimizing socio-cognitive assessment in the diagnosis of neurocognitive disorders 
    Cerami, Chiara; Boccardi, Marina; Meli, Claudia; Panzavolta, Andrea; Funghi, Giulia; Festari, Cristina; Cappa, Stefano F.; Chatzikostopoulos, Thanos; Chicherio, Christian; Clarens, María Florencia; Ferreira de Oliveira, Fabricio; Di Lorenzo, Francesco; Filardi, Marco; Ibanez, Agustin; Girtler, Nicola; Lebouvier, Thibaud; Logroscino, Giancarlo; Luca, Antonella; MacPherson, Sarah E.; SIGNATURE initiative (Wiley, 2025-05-14)
    Harmonized neuropsychological assessment for neurocognitive disorders (NCDs) is an urgent priority in clinics. Neuropsychology assessments in NCDs seldom include tests exploring social cognitive skills. In 2022, we launched ...
  • Deficits of Alzheimer's Disease Neuropsychological Architecture Correlate with Specific Exosomal mRNA Expression: Evidence of a Continuum? 
    Barceló Martínez, Ernesto; Mosquera-Heredia, María I.; Vidal, Oscar M.; Bolívar, Daniel A.; Allegri, Ricardo Francisco; Morales, Luis C.; Silvera-Redondo, Carlos; Arcos-Burgos, Mauricio; Garavito-Galofre, Pilar; Vélez, Jorge I. (MDPI, 2025-05-20)
    Alzheimer's disease (AD) is a neurodegenerative disorder characterized by cognitive decline and complex molecular changes. Extracellular vesicles (EVs), particularly exosomes, play a key role in intercellular communication ...
  • Impact of genetic counseling and testing in individuals at high risk of familial Alzheimer's disease from Latin America: a non-randomized controlled trial 
    Bagnati, Pablo M.; Londoño Castaño, Marisol; Fernández, María Laura; Henao, Beatriz Mora; Chrem Méndez, Patricio Alexis; Aguillón, David; Varela, Luz Estela; Barbaran, Juan Diego; Leon, Yudy; Surace, Ezequiel Ignacio; Madrigal, Claudia C.; Picasso, Juan Pablo; Ramos, Claudia P.; Restrepo Fernández, Carlos M.; Vigo, Gabriela; Ramirez Aguilar, Laura; VargasCuadros, Gabriel Alberto; Arcos-Burgos, Mauricio; Longoria, Erika Mariana; Ziegemeier, Ellen; McDade, Eric; Bateman, Randall J.; Allegri, Ricardo Francisco; Lopera, Francisco; Llibre-Guerra, Jorge J. (Wiley, 2025-04-06)
    Introduction: This study involved evaluating a tailored genetic counseling and testing (GCT) protocol for families at risk of autosomal dominant Alzheimer's disease (ADAD) in Latin America (LatAm), focusing on essential ...
  • Resistance and resilience to Alzheimer's disease in Down syndrome 
    Boyle, Rory; Koops, Elouise A.; Ances, Beau; Andrews, Elizabeth J.; Arenaza-Urquijo, Eider M.; Benjanin, Alexandre; Brickman, Adam M.; Buckley, Rachel F.; Clas, Giulia Solange; Costello, Emmet; Coughlan, Gillian T.; Conley, Alexander C.; Deng, Feng; de Paula Faria, Daniele; Edwards, Natalie; Flores-Aguilar, Lisi; Fortea, Juan; Saidi, Ladan Ghazi; Head, Elizabeth; Hom, Christy L. (Wiley, 2025-04-28)
    Due to the high prevalence of Alzheimer's disease (AD) in adults with Down syndrome (DS), trisomy 21 is now considered a genetic form of AD (DSAD). A better understanding of factors that can prevent or delay AD is vital ...
  • Safety and efficacy of long-term gantenerumab treatment in dominantly inherited Alzheimer's disease: an open-label extension of the phase 2/3 multicentre, randomised, double-blind, placebo-controlled platform DIAN-TU trial 
    Bateman, Randall J.; Li, Yan; McDade, Eric; Llibre-Guerra, Jorge J.; Clifford, David B.; Atri, Alireza; Mills, Susan L.; Santacruz, Anna M.; Wang, Guoqiao; Supnet, Charlene; Benzinger, Tammie L. S.; Gordon, Brian A.; Ibanez, Laura; Klein, Gregory; Baudler, Monika; Doody, Rachelle S.; Delmar, Paul; Kerchner, Geoffrey A.; Allegri, Ricardo Francisco; Dominantly Inherited Alzheimer's Disease–Trials Unit (Elsevier, 2025-04)
    Background: Amyloid plaque removal by monoclonal antibody therapies slows clinical progression in symptomatic Alzheimer's disease; however, the potential for delaying the onset of clinical symptoms in asymptomatic people ...
  • Increasing hub disruption parallels dementia severity in autosomal dominant Alzheimer's disease 
    Jiaxin Cindy, Tu; Millar, Peter R.; Strain, Jeremy F.; Eck, Andrew; Adeyemo, Babatunde; Snyder, Abraham Z.; Daniels, Alisha; Karch, Celeste; Huey, Edward D.; McDade, Eric; Day, Gregory S.; Yakushev, Igor; Hassenstab, Jason; Morris, John; Llibre-Guerra, Jorge J.; Ibanez, Laura; Jucke, Mathias; Chrem Méndez, Patricio Alexis; Dominantly Inherited Alzheimer Network (MIT Press, 2024)
    Hub regions in the brain, recognized for their roles in ensuring efficient information transfer, are vulnerable to pathological alterations in neurodegenerative conditions, including Alzheimer's disease (AD). Computational ...
  • 2- Cognitive Impairment and Dementia in Latin American Individuals with Parkinsonism and Parkinson’s Disease: A 10/66 Dementia Research Group Study (Ana Luisa Sosa) 
    Sosa, Ana Luisa; Khan, N.; Arruabarrena, Micaela María; Kim, D.J.; Jiang, M.; Llibre-Guerra, Jorge J.; Rodriguez-Salgado, A.M.; Acosta, I.; Acosta, D.; Jimenez-Velasquez, I.Z.; Guerra, M.; Salas, A.; López-Contreras, R.; Dhara, Santana; Hesse, H.; Tanner, C.; Prina, M.; Llibre-Guerra, J.J.; 10/66 Dementia ResearchGroup (International Psichogeriatrics Association, 2024-09)
  • Protocolo de valoración neuroconductual estandarizada y de interpretación clínica de pacientes con trastornos crónicos de conciencia 
    Russo, María Julieta; Pavón, Hernán Marcelo; Deschle, Florencia; Marroquín, María Verónica; Aliaga, Orlando; Sampayo, María de la Paz (Elsevier, 2025-03-20)
    En este trabajo investigamos la literatura existente acerca de la posibilidad de que algunos hallazgos clínicos puedan ser de utilidad para el diagnóstico de la presencia de contenido de conciencia en los pacientes con ...
  • Longitudinal analysis of a dominantly inherited Alzheimer disease mutation carrier protected from dementia 
    Llibre Guerra, Jorge J.; Fernandez, M. Victoria; Joseph-Mathurin, Nelly; Bian, Shijia; Carter, Kathleen; Li, Yan; Aschenbrenner, Andrew J.; Pottier, Cyril; Sigurdson, Wendy; McDade, Eric; Gordon, Brian A.; Renton, Alan E.; Benzinger, Tammie L. S.; Ibañez, Laura; Barthelemy, Nico; Dominantly Inherited Alzheimer Network (Nature Publishing Company, 2025-02-10)
    We conducted an in-depth longitudinal study on an individual carrying the presenilin 2 p.Asn141Ile mutation, traditionally associated with dominantly inherited Alzheimer's disease (AD), who has remarkably remained asymptomatic ...
  • Experts envision a valuable role for tau-PET in clinical practiceand drug trials 
    Vermeiren, Marie R.; Calandri, Ismael Luis; van der Flier, Wiesje M.; van de Giessen, Elsmarieke; Ossenkoppele, Rik (Wiley, 2024)
    Background: Recent advancements in Alzheimer’s disease (AD) biomarker researchand AD drug trials prompt reflection on the value and appropriate use of tau-PET infuture clinical practice and trials. We therefore conducted ...
  • Development of a Multidomain Composite InterventionEngagement Score in the U.S. POINTER Trial 
    Ghadimi Nouran, Mina; Katula, Jeffrey A.; Ventrelle, Jennifer; Graef, Sarah; Garcia, Katelyn R.; Lovato, Laura; Wilmoth, Sharon; Woolard, Nancy; Leng, Xiaoyan; Calandri, Ismael Luis; Snyder, Heather M.; Bake, Laura D. (Wiley, 2024)
    Background Multidomain lifestyle interventions have shown promise to slow cognitive decline and possibly prevent dementia. However, challenges arise in analyzing and interpreting treatment response when participants vary ...

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