Neurología Cognitiva.artículos: Envíos recientes

  • Loss of Direct Vascular Contact to Astrocytes in the Hippocampus as an Initial Event in Alzheimer's Disease. Evidence from Patients, In Vivo and In Vitro Experimental Models 
    Pomilio, Carlos; Presa, Jessica; Oses, Camila; Vinuesa, Ángeles; Bentivegna, Melisa; Gregosa, Amal; Riudavets, Miguel; Sevlever, Gustavo Emilio; Galvan, V.; Levi, Valeria; Beauquis, Juan; Saravia, Flavia (Humana Press, 2024-01-03)
    Alzheimer's disease (AD) is characterized by the accumulation of aggregated amyloid peptides in the brain parenchyma and within the walls of cerebral vessels. The hippocampus-a complex brain structure with a pivotal role ...
  • Actualización en el uso y el manejo del litio en neuropsiquiatría 
    Corrales, Alejo; Cetkovich Bakmas, Marcelo; Abadi, Andrea; Camino, Sebastián; García Bonetto, Gerardo; Márquez López Mato, Andrea; Marengo, Eliana; Abraham, Estela; Maresca, Tomás; Bagnati, Pablo M.; Dallamea, Amalia; Canseco, Diego; Morra, Carlos; Corral, Ricardo; Sotelo, Daniel; Strejilevich, Sergio; Pessio, Julián; Vilapriño, Juan José; Vilapriño, Manuel; Rebok, Federico; Vázquez, Gustavo (Polemos, 2024-01-10)
    Lithium is an alkaline metal, used for more than 60 years in psychiatry, and currently considered the gold standard in the treatment of bipolar disorder (BD). According to recent evidence, this active ingredient is useful ...
  • A task force for diagnosis and treatment of people with Alzheimer's disease in Latin America 
    Lopera, Francisco; Custodio, Nilton; Rico-Restrepo, Mariana; Allegri, Ricardo Francisco; Barrientos, José Domingo; Garcia Batres, Estuardo; Calandri, Ismael Luis; Calero Moscoso, Cristian; Caramelli, Paulo; Duran Quiroz, Juan Carlos; Jansen, Angela Marie; Mimenza Alvarado, Alberto José; Nitrini, Ricardo; Parodi, Jose F.; Ramos, Claudia; Slachevsky, Andrea; Dozzi Brucki, Sonia María (Frontiers Research Foundation, 2023-07-11)
    Alzheimer's disease (AD) represents a substantial burden to patients, their caregivers, health systems, and society in Latin America and the Caribbean (LAC). This impact is exacerbated by limited access to diagnosis, ...
  • Neuroimaging within the Dominantly Inherited Alzheimer’s Network (DIAN): PET and MRI 
    McKay, Nicole S.; Gordon, Brian A.; Hornbeck, Russ C.; Jack, Clifford R.; Koeppe, Robert A.; Flores, Shaney; Keefe, Sarah J.; Hobbs, Diana A.; Joseph-Mathurin, Nelly; Wang, Qing; Rahmani, Farzaneh; Chen, Charles D.; McCullough, Austin; Koudelis, Deborah; Chua, Jasmin; Ances, Beau M.; Millar, Peter R.; Nickels, Mike; Allegri, Ricardo Francisco; Dominantly Inherited Alzheimer Network (bioRxiv, 2022-03-30)
    The Dominantly Inherited Alzheimer Network (DIAN) Observational Study is an international collaboration studying autosomal dominant Alzheimer disease (ADAD). This rare form of Alzheimer disease (AD) is caused by mutations ...
  • Latin American Initiative for Lifestyle Intervention to Prevent Cognitive Decline (LatAm-FINGERS): Study design and harmonization 
    Crivelli, Lucía; Calandri, Ismael Luis; Kimie Suemoto, Claudia; Salinas Contreras, Rosa María; Velilla, Lina M.; Sanches Yassuda, Mónica; Caramelli, Paulo; Lopera, Francisco; Nitrini, Ricardo; Sevlever, Gustavo Emilio; Sosa, Ana Luisa; Acosta, Daisy; Bérgamo, Yanina; Clarens, María Florencia; Demey, Ignacio; Helou, María Belén; Martin, María Eugenia; Querzé, Diego; Surace, Ezequiel Ignacio; Allegri, Ricardo Francisco (Wiley, 2023-05-19)
    Introduction: Latin American Initiative for Lifestyle Intervention to Prevent Cognitive Decline (LatAm-FINGERS) is the first non-pharmacological multicenter randomized clinical trial (RCT) to prevent cognitive impairment ...
  • Biomarkers for dementia in Latin American countries: Gaps and opportunities 
    Parra, Mario A.; Orellana, Paulina; León, Tomás; Cabello, Victoria G.; Henriquez, Fernando; Gomez, Rodrigo; Avalos, Constanza; Damián, Andrés; Slachevsky, Andrea; Ibañez, Agustín; Zetterberg, Henrik; Tijms, Betty M.; Yokoyama, Jennifer S.; Piña-Escudero, Stefanie D.; Cochran, J. Nicholas; Matallana, Diana L.; Acosta, Daisy; Allegri, Ricardo Francisco (John Wiley & Sons, 2022-09-13)
    Limited knowledge on dementia biomarkers in Latin American and Caribbean (LAC) countries remains a serious barrier. Here, we reported a survey to explore the ongoing work, needs, interests, potential barriers, and opportunities ...
  • Pattern and implications of neurological examination findings in autosomal dominant Alzheimer disease 
    Vöglein, Jonathan; Franzmeier, Nicolai; Morris, John C.; Dieterich, Marianne; McDade, Eric; Simon, Mikael; Preische, Oliver; Hofmann, Anna; Hassenstab, Jason; Benzinger, Tammie L.S.; Fagan, Anne M.; Noble, James M.; Berman, Sarah B.; Graff-Radford, Neill R.; Ghetti, Bernardino; Farlow, Martin R.; Chhatwal, Jasmeer P.; Chrem Méndez, Patricio Alexis; Allegri, Ricardo Francisco; Dominantly Inherited Alzheimer Network (John Wiley & Sons, 2022-05-24)
    Introduction: As knowledge about neurological examination findings in autosomal dominant Alzheimer disease (ADAD) is incomplete, we aimed to determine the frequency and significance of neurological examination findings in ...
  • "Pandemic Fatigue" in South America: A Multi-Center Report from Argentina, Bolivia, Paraguay, Peru, and Uruguay 
    Torales, Julio César; González-Urbieta, Israel; Barrios Coronel, Iván; Waisman Campos, Marcela; Terrazas-Landivar, Alexandra; Viola, Laura; Caycho-Rodríguez, Tomás; Melgarejo, Osvaldo; Navarro, Rodrigo Eduardo; García, Oscar; Almirón Santacruz, José; Castaldelli-Maia, João Mauricio; Ventriglio, Antonio (MDPI, 2023-03-04)
    The COVID-19 pandemic has had a heavy impact on daily life, leading to physical and psychosocial consequences. Nowadays, clinicians and health researchers are particularly interested in describing and facing the long-term ...
  • Design of a Non-Interventional Study to Assess Neurologists' Perspectives and Pharmacological Treatment Decisions in Early Alzheimer's Disease 
    Saposnik, Gustavo; Sánchez-Benavidez, Gonzalo; García-Arcelay, Elena; Franco-Macías, Emilio; Bensi, Catalina; Carmelingo, Sebastián; Allegri, Ricardo Francisco; Pérez-Martíne, David A.; Maurino, Jorge (Springer, 2023-03-23)
    Introduction: The current therapeutic landscape of Alzheimer's disease (AD) is evolving rapidly. Our treatment options include new anti-amyloid-β protein disease-modifying therapies (DMTs) that decrease cognitive decline ...
  • AD-causing variants that affect PSEN1 transmembrane domains are associated with faster neurodegeneration and cognitive decline compared to those affecting cytoplasmic domains 
    Schultz, Stephanie A.; Allegri, Ricardo Francisco; Schultz, Aaron P.; Goate, Alison M.; Levey, Allan I.; Fagan, Anne M.; Hanseeuw, Bernard J.; Koeppe, Robert A.; Gordon, Brian A.; Cruchaga, Carlos; Karch, Celeste M.; Chen, Charles D.; Xiong, Chengjie; Jack Jr, Clifford R.; Fitzpatrick, Colleen D.; McDade, Eric; Chui, Helena C.; Mori, Hiroshi; Lee, Jae-Hong; Noble, James M. (Wiley, 2022-12)
    Background Rates of cognitive and biomarker change in Autosomal Dominant Alzheimer disease (ADAD) vary substantially across individuals. Prior cross-sectional work suggests that the location of the pathogenic variant ...
  • The Nairobi Declaration-Reducing the burden of dementia in low- and middle-income countries (LMICs): Declaration of the 2022 Symposium on Dementia and Brain Aging in LMICs 
    Maestre, Gladys; Carrillo, María C.; Kalaria, Raj; Acosta, Daisy; Adams, Larry; Adoukonou, Thierry; Akinwande, Kazeem; Akinyemi, Joshua; Akinyemi, Rufus; Akpa, Onoja; Alladi, Suvarna; Allegri, Ricardo Francisco; Arizaga, Raul; Arshad, Faheem; Arulogun, Oyedunni; Babalola, David; Baiyewu, Olusegun; Bak, Thomas; Bellaj, Tarek; African Dementia Consortium (John Wiley & Sons, 2023-03-11)
    Resumen no disponible
  • Pathogenesis of Alzheimer's disease: Involvement of the choroid plexus 
    Čarna, Maria; Onyango, Isaac G.; Katina, Stanislav; Holub, Dušan; Novotny, Jan Sebastian; Nezvedova, Marketa; Jha, Durga; Nedelska, Zuzana; Lacovich, Valentina; Vande Vyvere, Thijs; Houbrechts, Ruben; Garcia-Mansfield, Krystine; Sharma, Ritin; David-Dirgo, Victoria; Vyhnalek, Martin; Texlova, Kateřina; Chaves, Hernán; Bakkar, Nadine; Pertierra, Lucía; Sevlever, Gustavo Emilio (Wiley, 2023-02-24)
    The choroid plexus (ChP) produces and is bathed in the cerebrospinal fluid (CSF), which in aging and Alzheimer's disease (AD) shows extensive proteomic alterations including evidence of inflammation. Considering inflammation ...
  • Cross-sectional and longitudinal comparisons of biomarkers and cognition among asymptomatic middle-aged individuals with a parental history of either autosomal dominant or late-onset Alzheimer's disease 
    Xiong, Chengjie; McCue, Lena M.; Buckles, Virginia; Grant, Elizabeth; Agboola, Folasade; Coble, Dean; Bateman, Randall J.; Fagan, Anne M.; Benzinger, Tammie L.S.; Hassenstab, Jason; Schindler, Suzanne E.; McDade, Eric; Moulder, Krista L.; Gordon, Brian A.; Cruchaga, Carlos; Day, Gregory S.; Ikeuchi, Takeshi; Suzuki, Kazushi; Allegri, Ricardo Francisco; Dominantly Inherited Alzheimer Network (Wiley, 2023-01-14)
    Background: Comparisons of late-onset Alzheimer's disease (LOAD) and autosomal dominant AD (ADAD) are confounded by age. Methods: We compared biomarkers from cerebrospinal fluid (CSF), magnetic resonance imaging, and ...
  • Multimodal brain age estimates relate to Alzheimer disease biomarkers and cognition in early stages: a cross-sectional observational study 
    Millar, Peter R.; Gordon, Brian A.; Luckett, Patrick H.; Benzinger, Tammie L.S.; Cruchaga, Carlos; Fagan, Anne M.; Hassenstab, Jason; Perrin, Richard J.; Schindler, Suzanne E.; Allegri, Ricardo Francisco; Day, Gregory S.; Farlow, Martin R.; Mori, Hiroshi; Nübling, Georg; Dominantly Inherited Alzheimer Network; Bateman, Randall J.; Morris, John C.; Ances, Beau M. (eLife Sciences Publications, 2023-01-06)
    Background: Estimates of 'brain-predicted age' quantify apparent brain age compared to normative trajectories of neuroimaging features. The brain age gap (BAG) between predicted and chronological age is elevated in symptomatic ...
  • Teleneuropsychological assessment in South America: A perspective from patients and neuropsychologists 
    Arruabarrena, Micaela María; Martin, María Eugenia; Calandri, Ismael Luis; Corvalán, Nicolás; Helou, María Belén; Martínez Canyazo, Carlos; Crivelli, Lucía (Universidad de la Costa, 2022-12-23)
    Teleneuropsychology (teleNP) in Argentina was promoted by the COVID-19 pandemic. This investigation aimed to evaluate patients’ and neuropsychologists’ satisfaction with teleNP and to identify the advantages and disadvantages ...
  • La Organización Mundial de la Salud acaba de lanzar un Blueprint for Dementia Research. Algunas notas para impulsar la investigación sobre la demencia en América Latina... 
    Allegri, Ricardo Francisco; Román, Fabián; Barceló Martínez, Ernesto (Universidad de la Costa, 2022-12-28)
    La demencia es la causa más importante de discapacidad y dependencia en los adultos mayores y actualmente afecta a más de 55 millones de personas, el 60% de las cuales vive en países de ingresos bajos y medios (PRMB). El ...
  • Change in Cerebrospinal Fluid Tau Microtubule Binding Region Detects Symptom Onset, Cognitive Decline, Tangles, and Atrophy in Dominantly Inherited Alzheimer's Disease 
    Horie, Kanta; Li, Yan; Barthélemy, Nicolas R.; Gordon, Brian A.; Hassenstab, Jason; Benzinger, Tammie L.S.; Fagan, Anne M.; Morris, John C.; Karch, Celeste M.; Xiong, Chengjie; Allegri, Ricardo Francisco; Chrem Méndez, Patricio Alexis; Ikeuchi, Takeshi; Kasuga, Kensaku; Noble, James M.; Farlow, Martin R.; Chhatwal, Jasmeer P.; Day, Gregory S.; Schofield, Peter R.; Dominantly Inherited Alzheimer Network (Wiley, 2023-03-16)
    Objective: Identifying cerebrospinal fluid measures of the microtubule binding region of tau (MTBR-tau) species that reflect tau aggregation could provide fluid biomarkers that track Alzheimer's disease related neurofibrillary ...
  • Comparison of amyloid burden in individuals with Down syndrome versus autosomal dominant Alzheimer's disease: a cross-sectional study 
    Boerwinkle, Anna H.; Gordon, Brian A.; Wisch, Julie K.; Flores, Shaney; Henson, Rachel L.; Butt, Omar H.; McKay, Nicole S.; Chen, Charles D.; Benzinger, Tammie L.S.; Fagan, Anne M.; Handen, Benjamin L.; Christian, Bradley T.; Head, Elizabeth; Mapstone, Mark; Rafii, Michael S.; Alzheimer's Biomarker Consortium-Down Syndrome; Dominantly Inherited Alzheimer Network; Allegri, Ricardo Francisco; Chrem Méndez, Patricio Alexis; Egido, Noelia (Elsevier, 2022-12-12)
    Background: Important insights into the early pathogenesis of Alzheimer's disease can be provided by studies of autosomal dominant Alzheimer's disease and Down syndrome. However, it is unclear whether the timing and spatial ...
  • Autosomal dominant and sporadic late onset Alzheimer's disease share a common in vivo pathophysiology 
    Morris, John C.; Weiner, Michael W.; Xiong, Chengjie; Beckett, Laurel A.; Coble, Dean; Saito, Naomi; Aisen, Paul S.; Allegri, Ricardo Francisco; Benzinger, Tammie L.S.; Berman, Sarah B.; Cairns, Nigel; Carrillo, María C.; Chui, Helena C.; Chhatwal, Jasmeer P.; Cruchaga, Carlos; Fagan, Anne M.; Farlow, Martin R.; Fox, Nick C.; Ghetti, Bernardino; Goate, Alison M. (Oxford University Press, 2022-10-21)
    The extent to which the pathophysiology of autosomal dominant Alzheimer's disease corresponds to the pathophysiology of 'sporadic' late onset Alzheimer's disease is unknown, thus limiting the extrapolation of study findings ...
  • Neurocognitive Assessment in Addictions 
    Waisman Campos, Marcela; Cerviño, Cecilia; Bagnati, Pablo M.; Navarro, Rodrigo Eduardo; Barrios Coronel, Iván; González-Urbieta, Israel; García Franco, Oscar; O’Higgins, Marcelo Gerardo; Castaldelli-Maia, João Mauricio; Ventriglio, Antonio; Almirón-Santacruz, José; Torales, Julio César (EFACIM. Editorial de la Facultad de Ciencias Médicas de la Universidad Nacional de Asunción, 2022-04)
    Introduction: This paper aims to provide a brief review of recent evidence considering addictionrelated cognitive factors. Clinical observations, conventional wisdom, and well-reasoned theoretical mechanisms suggest that ...

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