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Disrupted functional connectivity of the locus coeruleus in healthy adults with parental history of Alzheimer's disease

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dc.contributor.author Del Cerro, Inés
dc.contributor.author Villarreal, Mirta Fabiana
dc.contributor.author Abulafia, Carolina
dc.contributor.author Duarte-Abritta, Bárbara
dc.contributor.author Sánchez, Stella Maris
dc.contributor.author Castro, Mariana Nair
dc.contributor.author Bocaccio, Hernán
dc.contributor.author Ferrer, Isidre
dc.contributor.author Menchón, José Manuel
dc.contributor.author Sevlever, Gustavo Emilio
dc.contributor.author Nemeroff, Charles B.
dc.contributor.author Soriano-Mas, Carles
dc.contributor.author Guinjoan, Salvador Martín
dc.date.accessioned 2020-11-19T15:40:52Z
dc.date.available 2020-11-19T15:40:52Z
dc.date.issued 2020-04
dc.identifier.citation Del Cerro, I., Villarreal, M.F., Abulafia, C., Duarte-Abritta, B., Sánchez, S.M., Castro, M.N., Bocaccio, H., Ferrer, I., Menchón, J.M., Sevlever, G., Nemeroff, C.B., Soriano-Mas, C., Guinjoan, S.M., 2020. Disrupted functional connectivity of the locus coeruleus in healthy adults with parental history of Alzheimer’s disease. J Psychiatr Res 123, 81–88. https://doi.org/10.1016/j.jpsychires.2020.01.018 en_US
dc.identifier.uri https://repositorio.fleni.org.ar/handle/123456789/241
dc.identifier.uri https://doi.org/10.1016/j.jpsychires.2020.01.018
dc.description.abstract Prevention and early treatment strategies for Alzheimer's disease (AD) are hampered by the lack of research biomarkers. Neuropathological changes in the Locus Coeruleus (LC) are detected early in AD, and noradrenaline plays a neuroprotective role in LC projecting areas. We assessed functional connectivity (FC) of the brainstem in asymptomatic individuals at familial risk for AD hypothesizing that FC of the LC will be decreased in relation to not-at-risk individuals. Thirty-one offspring of patients with late-onset AD (O-LOAD) (22 females; mean age ± SD = 50.36 ± 8.32) and 28 healthy controls (HC) (20 females; mean age ± SD = 53.90 ± 8.44) underwent a neurocognitive evaluation and a resting-state functional magnetic resonance imaging acquisition. In FC analyses we evaluated whole-brain global connectivity of the brainstem area, and subsequently assessed seed-to-voxel FC patterns from regions showing between-group differences. O-LOAD individuals scored worse in neurocognitive measures of memory and overall functioning (pFDR<0.05). In imaging analyses, we observed that O-LOAD individuals showed decreased global connectivity in a cluster encompassing the left LC (peak = -4, -34, -32, pTFCE<0.05). Seed-to-voxel analyses revealed that this finding was largely explained by decreased connectivity between the LC and the cerebellar cortex. Moreover, FC between the LC and the left cerebellum correlated positively with delayed recall scores. FC between the LC and the cerebellar cortex is decreased in the healthy offspring of patients with LOAD, such connectivity measurements being associated with delayed memory scores. The assessment of FC between the LC and the cerebellum may serve as a biomarker of AD vulnerability. en_US
dc.language.iso eng en_US
dc.publisher Pergamon Press en_US
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by/2.5/ar/
dc.subject Enfermedad de Alzheimer en_US
dc.subject Alzheimer Disease en_US
dc.title Disrupted functional connectivity of the locus coeruleus in healthy adults with parental history of Alzheimer's disease en_US
dc.type info:eu-repo/semantics/publishedVersion
dc.type info:eu-repo/semantics/article en_US
dc.description.fil Fil: Sevlever, Gustavo Emilio. Fleni. Departamento de Neuropatología y Biología Molecular. Laboratorio de Biología Molecular; Argentina.
dc.description.fil Fil: Abulafia, Carolina. Fleni. Grupo de Investigación en Neurociencias Aplicadas a las Alteraciones de la Conducta; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.
dc.description.fil Fil: Nemeroff, Charles B. The University of Texas. Dell Medical School. Institute of Early Life Adversity Research; Estados Unidos.
dc.description.fil Fil: Villarreal, Mirta Fabiana. Fleni. Grupo de Investigación en Neurociencias Aplicadas a las Alteraciones de la Conducta; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.
dc.description.fil Fil: Guinjoan, Salvador Martín. Fleni. Grupo de Investigación en Neurociencias Aplicadas a las Alteraciones de la Conducta; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fleni. Servicio de Psiquiatría; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Psiquiatría y Salud Mental; Argentina.
dc.description.fil Fil: Duarte-Abritta, Bárbara. Fleni. Grupo de Investigación en Neurociencias Aplicadas a las Alteraciones de la Conducta; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.
dc.description.fil Fil: Sánchez, Stella Maris. Fleni. Grupo de Investigación en Neurociencias Aplicadas a las Alteraciones de la Conducta; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.
dc.description.fil Fil: Castro, Mariana Nair. Fleni. Grupo de Investigación en Neurociencias Aplicadas a las Alteraciones de la Conducta; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fleni. Servicio de Psiquiatría; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Psiquiatría y Salud Mental; Argentina.
dc.description.fil Fil: Bocaccio, Hernán. Fleni. Grupo de Investigación en Neurociencias Aplicadas a las Alteraciones de la Conducta; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.
dc.description.fil Fil: Ferrer, Isidre. University of Barcelona. Facultad de Medicina y Ciencias de La Salud. Department of Pathology and Experimental Therapeutics. Institute of Neurosciences; España. L'Hospitalet de Llobregat. Department of Pathologic Anatomy, Bellvitge University Hospital. Bellvitge Biomedical Research Institute-IDIBELL; España. Network Center for Biomedical Research on Neurodegenerative Diseases (CIBERNED); España.
dc.description.fil Fil: Menchón, José Manuel. L'Hospitalet de Llobregat. Bellvitge University Hospital. Department of Psychiatry. Bellvitge Biomedical Research Institute-IDIBELL; España. L'Hospitalet de Llobregat. Barcelona University. Faculty of Medicine. Department of Clinical Sciences; España. Network Center for Biomedical Research on Mental Health (CIBERSAM); España.
dc.description.fil Fil: Soriano-Mas. L'Hospitalet de Llobregat. Bellvitge University Hospital. Department of Psychiatry. Bellvitge Biomedical Research Institute-IDIBELL; España. Network Center for Biomedical Research on Mental Health (CIBERSAM); España. Universitat Autonoma de Barcelona. Department of Psychobiology and Methodology in Health Sciences; España.
dc.relation.ispartofVOLUME 123
dc.relation.ispartofPAGINATION 81-88
dc.relation.ispartofCOUNTRY Inglaterra
dc.relation.ispartofCITY Oxford
dc.relation.ispartofISSN 1879-1379
dc.type.snrd info:ar-repo/semantics/artículo es_ES


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