Enfermedades Desmielinizantes.artículos: Recent submissions

  • Treatment strategies and responses for attacks of neuromyelitis optica spectrum disorder: A real-world retrospective cohort study 
    Carnero Contentti, Edgar; Lopez, Pablo A.; Pettinicchi, Juan Pablo; Miguez, Jimena; Patrucco, Liliana; Cristiano, Edgardo; Liwacki, Susana; Tkachuk, Verónica; Balbuena, María Eugenia; Vrech, Carlos; Deri, Norma; Correale, Jorge; Marrodán, Mariano; Ysrraelit, María Célica; Leguizamón, Felisa; Luetic, Geraldine; Tavolini, Darío; Mainella, Carolina; Zanga, Gisela; Burgos, Marcos; Hryb, Javier; Barboza, Andrés; Lazaro, Luciana; Alonso, Ricardo; Fernández Liguori, Nora; Nadur, Débora; Alonso Serena, Marina; Caride, Alejandro; Rojas, Juan I. (Elsevier, 2024-07-15)
    We aimed to assess the treatment strategies utilized in patients with neuromyelitis optica spectrum disorder (NMOSD) experiencing relapses, including their frequency, types, and response after 6 months based on the Expanded ...
  • Real-World Effectiveness and Safety of Cladribine in Multiple Sclerosis: Longitudinal Data From the Nationwide Registry in Argentina 
    Rojas, Juan Ignacio; Alonso, Ricardo; Luetic, Geraldine G.; Patrucco, Liliana; Casas, Magdalena; Silva, Berenice Anabel; Miguez, Jimena; Deri, Norma; Vrech, Carlos; Liwacki, Susana; Piedrabuena, Raúl; Silva, Emanuel; Tkachuk, Verónica A.; Burgos, Marcos; Tavolini, Darío; Zanga, Gisela; Alvez Pinheiro, Amelia; Hryb, Javier Pablo; Leguizamon, Felisa; Knorre, Eduardo; López, Pablo Adrián; Martínez, Alejandra Diana; Carrá, Adriana; Alonso Serena, Marina; Cristiano, Edgardo; Correale, Jorge; Garcea, Orlando; Fernández Liguori, Nora; Carnero Contentti, Edgar (Lippincott Williams & Wilkins, 2024-05-23)
    Objective: The aim was to evaluate patient profiles, effectiveness and safety of cladribine (CLAD) in patients with relapsing-remitting multiple sclerosis in Argentina. Methods: This was a substudy included in RelevarEM ...
  • Transferrin Enhances Neuronal Differentiation 
    Pérez, María Julia; Carden, Tomás Roberto; Dos Santos Claro, Paula Ayelen; Silberstein, Susana; Páez, Pablo Martin; Cheli, Veronica Teresita; Correale, Jorge; Pasquini, Juana María (Sage, 2023-04-24)
    Although transferrin (Tf) is a glycoprotein best known for its role in iron delivery, iron-independent functions have also been reported. Here, we assessed apoTf (aTf) treatment effects on Neuro-2a (N2a) cells, a mouse ...
  • Selection of disease modifying therapies in multiple sclerosis based on patient's age and disease activity: Data from a nationwide registry 
    Piedrabuena, María Agustina; Correale, Jorge; Fiol, Marcela Paula; Marrodán, Mariano; Ysrraelit, María Célica (Elsevier, 2024-05-16)
    Background: Knowledge of the safety and efficacy of disease-modifying therapies (DMTs) in older patients with Multiple Sclerosis (pwMS) is limited due to their exclusion from clinical trials. Our purpose is to evaluate the ...
  • Occurrence of area postrema syndrome during follow-up: phenotype and influence over NMOSD activity in LATAM in real-world settings. 
    Pestchanker, Claudia; Bertado Cortez, Brenda; Lana Peixoto, Marco A.; Gortari, José Ignacio; Castro Suarez, Sheila; Caparo Zamalloa, César; Galiana, Graciana Lourdes; Peñalver, Francisco; Daccach Marques, Vanessa; Messias, Katharina; Galleguillos Goiry, Lorna; García, Fernando; Rojas, Juan Ignacio; Patrucco, Liliana; Cristiano, Edgardo; Tkachuk, Verónica A.; Liwacki, Susana; Correale, Jorge; Marrodán, Mariano; Ysrraelit, María Célica; Vrech, Carlos; Deri, Norma; Leguizamon, Felisa; Tavolini, Darío; Mainella, Carolina; Zanga, Gisela; Alonso Serena, Marina; Ciampi, Ethel; Herval Ribeiro Soares Neto, Herval; López, Pablo Adrián; Carnero Contentti, Edgar (Springer-Verlag, 2024-03-17)
    Introduction: We aimed to assess the frequency, duration, and severity of area postrema syndrome (APS) during follow-up in neuromyelitis optica spectrum disorder (NMOSD) patients, as well as its association with inflammatory ...
  • Core data set for real world data in multiple sclerosis: customization for latin america from a global task force recommendation. 
    Rojas, Juan Ignacio; Gracia, Fernando; Parciak, T.; Alonso, R. N.; Becker, Jefferson; Treviño Frenk, Irene; Alonso Serena, Marina; Giunta, Diego Hernán; Abad, P.; Carnero Contentti, Edgar; Carrá, Adriana; Correa Díaz, Edgar Patricio; Correale, Jorge; Cristiano, Edgardo; Flores, José; Fruns, Manuel; Galleguillos Goiry, Lorna; Garcea, Orlando; Hamuy, Fernando; Lana Peixoto, Marco A.; Navas, Carlos; Papais Alvarenga, Regina; Patrucco, Liliana; Rivera, V.; Tenembaum, S. N.; Ysrraelit, María Célica; Peeters, L.M. (Viguera, 2024-04-01)
    Introduction: The primary objective of the core data set is to reduce heterogeneity and promote harmonization among data sources in EM, thereby reducing the time needed to execute real life data collection efforts. Recently, ...
  • Comorbidities in multiple sclerosis and their influence on the choice of treatment 
    Barboza, Andrés G.; Sinay, Vladimiro; Alonso, Ricardo; Carnero Contentti, Edgar; Hryb, Javier Pablo; Silva, Berenice Anabel; Tavolini, Darío; Ysrraelit, María Célica; Correale, Jorge (Revista de Neurología, 2024-03-16)
    Los estudios clínicos de tratamientos para personas con esclerosis múltiple (pEM) se realizan en poblaciones seleccionadas, que excluyen a pacientes que presenten comorbilidades o medicaciones concomitantes. Sin embargo, ...
  • Remyelinating effect driven by transferrin-loaded extracellular vesicles 
    Mattera, Vanesa S.; Occhiuzzi, Federico; Correale, Jorge; Pasquini, Juana María (Wiley, 2023-10-20)
    Extracellular vesicles (EVs) are involved in diverse cellular functions, playing a significant role in cell-to-cell communication in both physiological conditions and pathological scenarios. Therefore, EVs represent a ...
  • Mortality of neuromyelitis optica spectrum disorder patients in an Argentinean population: A study from the RelevarEM registry 
    Carnero Contentti, Edgar; López, Pablo Adrián; Pettinicchi, Juan Pablo; Criniti, Juan; Pappolla, Agustín; Miguez, Jimena; Cristiano, Edgardo; Patrucco, Liliana; Liwacki, Susana; Tkachuk, Verónica A.; Balbuena Aguirre, María Eugenia; Vrech, Carlos; Deri, Norma; Correale, Jorge; Marrodán, Mariano; Ysrraelit, María Célica; Leguizamon, Felisa; Luetic, Geraldine G.; Menichini, María Laura; Tavolini, Darío (Sage, 2023-10-17)
    We aimed to evaluate mortality and causes of death among Argentinean neuromyelitis optica spectrum disorder (NMOSD) patients and identify predictors of death. Retrospective study included 158 NMOSD patients and 11 (7%) ...
  • A plain language summary on assessing the long-term effectiveness of cladribine tablets in people living with relapsing multiple sclerosis: The CLASSIC-MS study 
    Giovannoni, Gavin; Boyko, Alexey; Correale, Jorge; Edan, Gilles; Freedman, Mark S.; Montalban, Xavier; Rammohan, Kottil; Stefoski, Dusan; Yamout, Bassem; Leist, Thomas; Aydemir, Aida; Borsi, Laszlo; Verdun di Cantogno, Elisabetta (Future Medicine, 2023-08-03)
    What is this summary about?: Previous studies have shown that people living with multiple sclerosis (MS) treated with cladribine tablets have fewer relapses (where new symptoms occur or existing symptoms get worse for 24 ...
  • Microglia-derived extracellular vesicles in homeostasis and demyelination/remyelination processes 
    Wies Mancini, Victoria Sofía Berenice; Mattera, Vanesa S.; Pasquini, Juana María; Pasquini, Laura Andrea; Correale, Jorge (Wiley on behalf of the International Society for Neurochemistry, 2023-12-06)
    Microglia (MG) play a crucial role as the predominant myeloid cells in the central nervous system and are commonly activated in multiple sclerosis. They perform essential functions under normal conditions, such as actively ...
  • Incidence of SARS-CoV-2 infection in patients with multiple sclerosis who received SARS-CoV-2 vaccines and are under treatment with high-efficacy therapies in Argentina 
    Carnero Contentti, Edgar; López, Pablo Adrián; Pappolla, Agustín; Alonso, Ricardo; Silva, Berenice Anabel; Deri, Norma; Balbuena Aguirre, María Eugenia; Burgos, Marcos; Luetic, Geraldine G.; Alvez Pinheiro, Amelia; Cabrera, Mariela; Hryb, Javier Pablo; Nofal, Pedro G.; Pestchanker, Claudia; Vrech, Carlos; Tavolini, Darío; Marrodán, Mariano; Ysrraelit, María Célica; Correale, Jorge; RelevarEM investigators (Springer-Verlag Italia, 2023-12-30)
    We aimed to evaluate the incidence of SARS-CoV-2 breakthrough infection of SARS-CoV-2 vaccines in people with MS (PwMS) on high-efficacy disease-modifying therapies (HET) included in the national MS registry in Argentina ...
  • Etiology of White Matter Hyperintensities in Autosomal Dominant and Sporadic Alzheimer Disease 
    Shirzadi, Zahra; Schultz, Stephanie A.; Yau, Wai-Ying W.; Joseph-Mathurin, Nelly; Fitzpatrick, Colleen D.; Levin, Raina; Kantarci, Kejal; Preboske, Gregory M.; Jack Jr, Clifford R.; Farlow, Martin R.; Hassenstab, Jason; Jucker, Mathias; Morris, John C.; Xiong, Chengjie; Karch, Celeste M.; Levey, Allan I.; Gordon, Brian A.; Schofield, Peter R.; Allegri, Ricardo Francisco; Dominantly Inherited Alzheimer Network; Alzheimer’s Disease Neuroimaging Initiative (American Medical Association, 2023-12-01)
    Importance: Increased white matter hyperintensity (WMH) volume is a common magnetic resonance imaging (MRI) finding in both autosomal dominant Alzheimer disease (ADAD) and late-onset Alzheimer disease (LOAD), but it remains ...
  • Clinical characterization of long-term multiple sclerosis (COLuMbus) patients in Argentina: A cross-sectional non-interventional study 
    Deri, Norma; Barboza, Andrés G.; Vrech, Carlos; Rey, Roberto D.; Burgos, Marcos; Fiol, Marcela Paula; Calvo Vildoso, Christian; Patrucco, Liliana; José, Gustavo; Aliberti, Paula; Chirico, Daniela; Federico, María B.; Seifer, Gustavo; Piedrabuena, Raúl (Elsevier, 2023-12-31)
    Background: Most Multiple Sclerosis (MS) clinical trials fail to assess the long-term effects of disease-modifying therapies (DMT) or disability. Methods: COLuMbus was a single-visit, cross-sectional study in Argentina ...
  • Frequency of new asymptomatic MRI lesions during attacks and follow-up of patients with NMOSD in a real-world setting 
    Carnero Contentti, Edgar; López, Pablo Adrián; Tkachuk, Verónica A.; Vrech, Carlos; Zarate, María Agustina; Correale, Jorge; Deri, Norma; Luetic, Geraldine G.; Marrodán, Mariano; Pagani Cassará, Fátima; Tavolini, Darío; Ysrraelit, María Célica; Balbuena Aguirre, María Eugenia; Hryb, Javier Pablo; Chiganer, Edson Hernán; Leguizamon, Felisa; Knorre, Eduardo; Zanga, Gisela; Pestchanker, Claudia; Barboza, Andrés G. (Sage, 2023-07-25)
    Background: We aimed to assess the frequency of new asymptomatic lesions on brain and spinal imaging (magnetic resonance imaging (MRI)) and their association with subsequent relapses in a large cohort of neuromyelitis ...
  • Differential diagnosis of suspected multiple sclerosis: an updated consensus approach 
    Solomon, Andrew J.; Arrambide, Georgina; Brownlee, Wallace J.; Flanagan, Eoin P.; Amato, María Pía; Amezcua, Lilyana; Banwell, Brenda L.; Barkhof, Frederik; Corboy, John R.; Correale, Jorge; Fujihara, Kazuo; Graves, Jennifer; Harnegie, Mary Pat; Hemmer, Bernhard; Lechner-Scott, Jeannette; Marrie, Ruth Ann; Newsome, Scott D.; Rocca, Maria A.; Royal, Walter; Waubant, Emmanuelle L. (Lancet, 2023-07-19)
    Accurate diagnosis of multiple sclerosis requires careful attention to its differential diagnosis-many disorders can mimic the clinical manifestations and paraclinical findings of this disease. A collaborative effort, ...
  • Global Barriers to the Diagnosis of Multiple Sclerosis: Data From the Multiple Sclerosis International Federation Atlas of MS, Third Edition 
    Solomon, Andrew J.; Marrie, Ruth Ann; Viswanathan, Shanthi; Correale, Jorge; Magyari, Melinda; Robertson, Neil P.; Saylor, Deanna R.; Kaye, Wendy; Rechtman, Lindsay; Bae, Eunchan; Shinohara, Russell; King, Rachel; Laurson-Doube, Joanna; Helme, Anne (Lippincott Williams & Wilkins, 2023-06-15)
    Background and objectives: Recent data suggest increasing global prevalence of multiple sclerosis (MS). Early diagnosis of MS reduces the burden of disability-adjusted life years and associated health care costs. Yet ...
  • Latin American consensus recommendations on the risk of infections in people with multiple sclerosis treated with disease modifying drugs 
    Silva, Berenice Anabel; Carnero Contentti, Edgar; Becker, Jefferson; Carranza, José I.; Correa Díaz, Edgar Patricio; Galleguillos Goiry, Lorna; Garcea, Orlando; Gracia, Fernando; Hamuy, Fernando; Macías, Miguel Angel; Navas, Carlos; Nuñez, Sebastián; Rojas, Juan Ignacio; Farez, Mauricio Franco; Alonso, Ricardo; López, Pablo Adrián (Elsevier, 2023-06-20)
    Introduction: The emergence of several therapeutic options in multiple sclerosis (MS), which significantly modify the immune system functioning, has led to the need for the consideration of additional factors, such as risk ...
  • Serological response to SARS-CoV-2 vaccines in patients with multiple sclerosis in Argentina 
    Rojas, Juan Ignacio; Alonso, Ricardo; Cabrera, Mariela; Carnero Contentti, Edgar; Cristiano, Edgardo; Deri, Norma; Hryb, Javier Pablo; López, Pablo Adrián; Luetic, Geraldine G.; Patrucco, Liliana; Tkachuk, Verónica A.; Ysrraelit, María Célica; Zanga, Gisela; Cruces, Leonel; Turk, Gabriela; Longueira, Yesica; Laufer, Natalia; Nuñez, Sebastián (Fundación Revista Medicina, 2023-03-02)
    Introduction: The objective was to assess the immunogenicity and effectiveness of vaccines against SARSCoV-2 in multiple sclerosis (MS) patients included in the Argentinean MS registry. Methods: A prospective cohort ...
  • Clinically relevant increases in serum neurofilament light chain and glial fibrillary acidic protein in patients with Susac syndrome 
    Plantone, Domenico; Sabatelli, Eleonora; Locci, Sara; Marrodán, Mariano; Laakso, Sini M.; Mateen, Farrah J.; Feresiadou, Amalia; Buelens, Tom; Bianco, Assunta; Fiol, Marcela Paula; Correale, Jorge; Tienari, Pentti; Calabresi, Paolo; De Stefano, Nicola; Iorio, Raffaele (Wiley, 2023-06-19)
    Background and purpose: Serum levels of neurofilament light chain (sNfL) and glial fibrillary acidic protein (sGFAP) are promising neuro-axonal damage and astrocytic activation biomarkers. Susac syndrome (SS) is an ...

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