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Diagnosis of Rapidly Progressive Dementia in a Referral Center in Argentina

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dc.contributor.advisor
dc.contributor.author Acosta, Julián Nicolás
dc.contributor.author Ricciardi, Mario Emiliano
dc.contributor.author Alessandro, Lucas
dc.contributor.author Carnevale, Martín Diego
dc.contributor.author Farez, Mauricio Franco
dc.contributor.author Nagel, Vanesa
dc.contributor.author Allegri, Ricardo Francisco
dc.contributor.author Varela, Francisco José
dc.date.accessioned 2019-10-03T15:19:42Z
dc.date.available 2019-10-03T15:19:42Z
dc.date.issued 2020-01-01
dc.identifier.citation Acosta, J.N., Ricciardi, M.E., Alessandro, L., Carnevale, M., Farez, M.F., Nagel, V., Allegri, R.F., Varela, F., 2020. Diagnosis of Rapidly Progressive Dementia in a Referral Center in Argentina. Alzheimer Dis Assoc Disord 34, 54–58. https://doi.org/10.1097/WAD.0000000000000337 en_US
dc.identifier.uri https://doi.org/10.1097/WAD.0000000000000337
dc.identifier.uri https://repositorio.fleni.org.ar/handle/123456789/45
dc.description.abstract INTRODUCTION: Rapidly progressive dementia (RPD) is a broadly defined clinical syndrome. Our aim was to describe clinical and ancillary study findings in patients with RPD and evaluate their diagnostic performance for the identification of nonchronic neurodegenerative rapidly progressive dementia (ncnRPD). METHODS: We reviewed clinical records and ancillary methods of patients evaluated for RPD at our institution in Buenos Aires, Argentina from 2011 to 2017. We compared findings between chronic neurodegenerative RPD and ncnRPD and evaluated the diagnostic metrics using receiver operating characteristic curves. RESULTS: We included 104 patients with RPD, 29 of whom were chronic neurodegenerative RPD and 75 of whom were ncnRPD. The 6-month time to dementia cutpoint had a sensitivity of 89% and specificity of 100% for ncnRPD, with an area under the receiver operating characteristic curve of 0.965 (95% confidence interval=0.935-0.99; P<0.001). A decision tree that included time to dementia, brain magnetic resonance imaging, and cerebrospinal fluid analysis identified ncnRPD patients with a sensitivity of 100%, specificity of 79%, positive predictive value of 93%, and negative predictive value of 100% overall. DISCUSSION: RPD is a clinical syndrome that comprises different diagnoses, many of them for treatable diseases. Using the time to dementia, brain magnetic resonance imaging, and cerebrospinal fluid analysis when triaging these patients could help identify those diseases that need to be studied more aggressively. en_US
dc.language.iso eng en_US
dc.publisher Lippincott Williams & Wilkins en_US
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by/2.5/ar/
dc.subject RPD en_US
dc.subject Rapidly Progressive Dementia en_US
dc.subject Demencia Rápidamente Progresiva en_US
dc.subject DRP en_US
dc.subject Prion Diseases en_US
dc.subject Enfermedades por Prión en_US
dc.subject Cognitive Dysfunction en_US
dc.subject Disfunción Cognitiva en_US
dc.subject Limbic Encephalitis en_US
dc.subject Encefalitis Límbica en_US
dc.subject AIDS Dementia Complex en_US
dc.subject Complejo SIDA Demencia en_US
dc.title Diagnosis of Rapidly Progressive Dementia in a Referral Center in Argentina en_US
dc.type info:eu-repo/semantics/publishedVersion
dc.type info:eu-repo/semantics/article en_US
dc.description.fil Fil: Acosta, Julián Nicolás. Fleni. Departamento de Neurología; Argentina.
dc.description.fil Fil: Ricciardi, Mario Emiliano. Fleni. Departamento de Neurología; Argentina.
dc.description.fil Fil: Alessandro, Lucas. Fleni. Departamento de Neurología; Argentina
dc.description.fil Fil: Carnevale, Martín Diego. Fleni. Departamento de Diagnóstico por Imágenes; Argentina.
dc.description.fil Fil: Farez, Mauricio Franco. Fleni. Centro de Epidemiología, Bioestadística y Salud Pública; Argentina
dc.description.fil Fil: Nagel, Vanesa. Fleni. Departamento de Neurología; Argentina
dc.description.fil Fil: Allegri, Ricardo Francisco. Fleni. Departamento de Neurología. Servicio de Neurología Cognitiva, Neuropsicología y Neuropsiquiatría; Argentina.
dc.relation.ispartofVOLUME 34
dc.relation.ispartofNUMBER 1
dc.relation.ispartofPAGINATION 54–58
dc.relation.ispartofCOUNTRY Estados Unidos
dc.relation.ispartofCITY Hagerstown
dc.relation.ispartofTITLE Alzheimer Disease & Associated Disorders
dc.relation.ispartofISSN 1546-4156
dc.type.snrd info:ar-repo/semantics/artículo es_ES


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