• Characterization of a novel heterozygous variant in the histidyl-tRNA synthetase gene associated with Charcot-Marie-Tooth disease type 2W 

  Wilhelm, Sarah D. P.; Moresco, Angelica A.; Rivero, Alberto Daniel; Mok Siu, Victoria; Heinemann, Ilka U. (Taylor & Francis, 2024-10-01)

  Heterozygous pathogenic variants in the histidyl-tRNA synthetase (HARS) gene are associated with Charcot-Marie-Tooth (CMT) type 2W disease, classified as an axonal peripheral neuropathy. To date, at least 60 variants causing ...
• HIV Modulates Osteoblast Differentiation via Upregulation of RANKL and Vitronectin 

  Freiberger, Rosa Nicole; López, Cynthia Alicia Marcela; Palma, María Belén; Cevallos, Cintia; Sviercz, Franco Agustin; Jarmolu, Patricio; García, Marcela Nilda; Quarleri, Jorge; Delpino, M. Victoria (MDPI AG, 2024-09-15)

  Bone loss is a prevalent characteristic among people with HIV (PWH). We focused on mesenchymal stem cells (MSCs) and osteoblasts, examining their susceptibility to different HIV strains (R5- and X4-tropic) and the subsequent ...
• CDK5 Deficiency Does not Impair Neuronal Differentiation of Human Induced Pluripotent Stem Cells but Affects Neurite Outgrowth 

  Mucci, Sofía; Clas, Giulia Solange; Allio, Camila Paola; Rodríguez Varela, María Soledad; Isaja, Luciana; Marazita, Mariela; Sevlever, Gustavo Emilio; Scassa, María Élida; Romorini, Leonardo (Humana Press, 2024-06-28)

  Cyclin-dependent kinase 5 (CDK5) is a protein kinase involved in neuronal homeostasis and development critical for neuronal survival. Besides, its deregulation is linked to neurodegenerative pathologies such as Alzheimer's ...
• Country-level gender inequality is associated with structural differences in the brains of women and men 

  Zugman, Andre; Alliende, Luz María; Medel, Vicente; A I Bethlehem, Richard; Seidlitz, Jakob; Ringlein, Grace; Arango, Celso; Arnatkevičiūtė, Aurina; Asmal, Laila; Bellgrove, Mark; Benegal, Vivek; Bernardo, Miquel; Billeke, Pablo; Bosch-Bayard, Jorge; Bressan, Rodrigo; Busatto, Geraldo F.; Castro, Mariana Nair; Chaim-Avancini, Tiffany; Compte, Albert; Villarreal, Mirta Fabiana (National Academy of Sciences, 2023-05-16)

  Gender inequality across the world has been associated with a higher risk to mental health problems and lower academic achievement in women compared to men. We also know that the brain is shaped by nurturing and adverse ...
• EFFECTS OF BACTERIAL LIPOPOLYSACCHARIDE AND SHIGA TOXIN ON INDUCED PLURIPOTENT STEM CELL-DERIVED MESENCHYMAL STEM CELLS 

  Martire-Greco, Daiana; La Greca, Alejandro; Castillo Montañez, Luis; Biani, María Celeste; Lombardi, Antonella; Birnberg-Weiss, Federico; Norris, Alessandra; Sacerdoti, Flavia; Amaral, María Marta; Rodrigues-Rodriguez, Nahuel; Pittaluga, Jose Ramón; Furmento, Verónica Alejandra; Landoni, Verónica Inés; Miriuka, Santiago Gabriel; Luzzani, Carlos Daniel; Fernández, Gabriela Cristina (Lippincott Williams & Wilkins, 2023-04-11)

  Background : Mesenchymal stem cells (MSCs) can be activated by different bacterial toxins. Lipopolysaccharides and Shiga Toxin (Stx) are the main toxins necessary for hemolytic uremic syndrome development. The main etiological ...
• Iron deficiency in astrocytes alters cellular status and impacts on oligodendrocyte differentiation. 

  Marcora, María Silvina; Mattera, Vanesa S.; Goñi, Pilar; Aybar, Florencia; Correale, Jorge; Pasquini, Juana María (Wiley Interscience, 2024-04)

  Iron deficiency (ID) has been shown to affect central nervous system (CNS) development and induce hypomyelination. Previous work from our laboratory in a gestational ID model showed that both oligodendrocyte (OLG) and ...
• Droplets for Gene Editing Using CRISPR-Cas9 and Clonal Selection Improvement Using Hydrogels. 

  Pérez Sosa, Camilo; Pérez, Maximiliano S.; Vallejo Janeta, Alexander Paolo; Bhansali, Shekhar; Miriuka, Santiago Gabriel; Lerner, Betiana (MDPI, 2024-02-19)

  Gene editing tools have triggered a revolutionary transformation in the realms of cellular and molecular physiology, serving as a fundamental cornerstone for the evolution of disease models and assays in cell culture ...
• Peritumoral adipose tissue promotes lipolysis and white adipocytes browning by paracrine action 

  Pagnotta, Priscila; Gantov, Mariana; Fletcher, Sabrina; Lombardi, Antonella; Crosbie, María Lujan; Santiso, Natalia; Ursino, Anabela; Frascarolli, Celeste; Amato, Alicia; Dreszman, Rubén; Calvo, Juan Carlos; Toneatto, Judith (Frontiers Research Foundation, 2023-04-26)

  Background: Stromal adipocytes and tumor breast epithelial cells undergo a mutual metabolic adaptation within tumor microenvironment. Therefore, browning and lipolysis occur in cancer associated adipocytes (CAA). However, ...
• A miR-137-Related Biological Pathway of Risk for Schizophrenia Is Associated With Human Brain Emotion Processing 

  Pergola, Giulio; Rampino, Antonio; Sportelli, Leonardo; Borcuk, Christopher James; Passiatore, Roberta; Di Carlo, Pasquale; Marakhovskaia, Aleksandra; Fazio, Leonardo; Amoroso, Nicola; Castro, Mariana Nair; Domenici, Enrico; Gennarelli, Massimo; Khlghatyan, Jivan; Christos Kikidis, Gianluca; Lella, Annalisa; Magri, Chiara; Monaco, Alfonso; Papalino, Marco; Parihar, Madhur; Popolizio, Teresa (Elsevier, 2023-11-22)

  Background: miR-137 is a microRNA involved in brain development, regulating neurogenesis and neuronal maturation. Genome-wide association studies have implicated miR-137 in schizophrenia risk but do not explain its involvement ...
• PluriBAC: A Versatile Baculovirus-Based Modular System to Express Heterologous Genes in Different Biotechnological Platforms 

  Amorós Morales, Leslie C.; Marchesini, Abril; Gómez Bergna, Santiago M.; García Fallit, Matías; Tongiani, Silvana E.; Vásquez, Larisa; Ferrelli, María Leticia; Videla Richardson, Guillermo Agustín; Candolfi, Marianela; Romanowski, Víctor; Pidre, Matías L. (MDPI, 2023-09-23)

  Baculoviruses are insect-specific pathogens widely used in biotechnology. In particular, the Autographa californica nucleopolyhedrovirus (AcMNPV) has been exploited as a platform for bio-inputs production. This is why the ...
• Role of hydroxymethylglutharyl-coenzyme A reductase in the induction of stem-like states in breast cancer 

  Marks, María Paula; Giménez, Carla Alejandra; Isaja, Luciana; Vera, Mariana Belén; Borzone, Francisco Raúl; Pereyra-Bonnet, Federico; Romorini, Leonardo; Videla Richardson, Guillermo Agustín; Chasseing, Norma Alejandra; Calvo, Juan Carlos; Vellón, Luciano (Springer-Verlag, 2024-02-28)

  Purpose: De novo synthesis of cholesterol and its rate-limiting enzyme, 3-hydroxy-3-methylglutharyl-coenzyme A reductase (HMGCR), is deregulated in tumors and critical for tumor cell survival and proliferation. However, ...
• Broad-Spectrum Antiviral Effect of Cannabidiol Against Enveloped and Nonenveloped Viruses 

  Marquez, Agostina B.; Vicente, Josefina; Castro, Eliana; Vota, Daiana; Rodríguez Varela, María Soledad; Lanza Castronuovo, Priscila A.; Fuentes, Giselle M.; Parise, Alejandro R.; Romorini, Leonardo; Alvarez, Diego E.; Bueno, Carlos A.; Ramirez, Cristina L.; Alaimo, Agustina; García, Cybele C. (Mary Ann Liebert, 2023-09-08)

  Introduction: Cannabidiol (CBD), the main non-psychoactive cannabinoid of the Cannabis sativa plant, is a powerful antioxidant compound that in recent years has increased interest due to causes effects in a wide range of ...
• Mitochondrial Peptide Humanin Facilitates Chemoresistance in Glioblastoma Cells 

  Peña Agudelo, Jorge A.; Pidre, Matías L.; García Fallit, Matías; Pérez Küper, Melanie; Zuccato, Camila; Nicola Candia, Alejandro J.; Marchesini, Abril; Vera, Mariana Belén; De Simone, Emilio; Giampaoli, Carla; Amorós Morales, Leslie C.; Gonzalez, Nazareno; Romanowski, Víctor; Videla Richardson, Guillermo Agustín; Seilicovich, Adriana; Candolfi, Marianela (MDPI, 2023-08-11)

  Humanin (HN) is a mitochondrial-derived peptide with robust cytoprotective effects in many cell types. Although the administration of HN analogs has been proposed to treat degenerative diseases, its role in the pathogenesis ...
• Spirituality and Cognitive Neurosciences 

  Allegri, Ricardo Francisco; Román, Fabián; Barceló Martínez, Ernesto (Universidad de la Costa, 2023-10-23)
• Editorial: Advances in platforms for disease modelling 

  Romorini, Leonardo; Baweja, Sukriti; Martin Mateos, Rosa Maria; Mehta, Gautam; Jalan-Sakrikar, Nidhi (Frontiers Media, 2023-04-19)

  Resumen no disponible
• Low-dimensional organization of global brain states of reduced consciousness 

  Perl, Yonatan Sanz; Pallavicini, Carla; Piccinini, Juan; Demertzi, Athena; Bonhomme, Vincent; Martial, Charlotte; Panda, Rajanikant; Alnagger, Naji; Annen, Jitka; Gosseries, Olivia; Ibañez, Agustín; Laufs, Helmut; Sitt, Jacobo D.; Jirsa, Viktor K.; Kringelbach, Morten; Laureys, Steven; Deco, Gustavo; Tagliazucchi, Enzo (Elsevier, 2023-05-11)

  Brain states are frequently represented using a unidimensional scale measuring the richness of subjective experience (level of consciousness). This description assumes a mapping between the high-dimensional space of ...
• Body mass index, waist circumference, insulin, and leptin plasma levels differentiate between clozapine-responsive and clozapine-resistant schizophrenia 

  Hönig, Guillermo; Daray, Federico M.; Rodante, Demián; Drucaroff, Lucas Javier; Gutiérrez, María Laura; Lenze, Mariela; García Bournissen, Facundo; Wikinski, Silvia (Sage, 2023-06-28)

  Background: Between 25% and 50% of patients suffering from treatment-resistant schizophrenia fail to achieve a clinical response with clozapine. The rapid identification and treatment of this subgroup of patients represents ...
• Chromatographic Scalable Method to Isolate Engineered Extracellular Vesicles Derived from Mesenchymal Stem Cells for the Treatment of Liver Fibrosis in Mice 

  Domínguez, Luciana M.; Bueloni, Bárbara; Cantero, María José; Albornoz, Milagros; Pacienza, Natalia; Biani, María Celeste; Luzzani, Carlos Daniel; Miriuka, Santiago Gabriel; García, Mariana; Atorrasagasti Fernández, María Catalina; Yannarelli, Gustavo; Bayo, Juan; Fiore, Esteban; Mazzolini, Guillermo (MDPI, 2023-05-31)

  New therapeutic options for liver cirrhosis are needed. Mesenchymal stem cell (MSC)-derived extracellular vesicles (EVs) have emerged as a promising tool for delivering therapeutic factors in regenerative medicine. Our aim ...
• The role of microfluidics and 3D-bioprinting in the future of exosome therapy 

  Amondarain, Mikele; Gallego, Idoia; Puras, Gustavo; Saenz-Del-Burgo, Laura; Luzzani, Carlos Daniel; Pedraz, José Luis (Elsevier, 2023-06-09)

  Exosome-based strategies constitute a promising tool for therapeutics, avoiding potential immunogenic and tumorigenic side-effects of cell therapies. However, the collection of a suitable exosome pool, and the need for ...
• Generation of two edited iPSCs lines by CRISPR/Cas9 with point mutations in PKP2 gene for arrhythmogenic cardiomyopathy in vitro modeling 

  Amín, Guadalupe; Castañeda, Sheila; Zabalegui, Federico; Belli, Carolina; Atorrasagasti Fernández, María Catalina; Miriuka, Santiago Gabriel; Moro, Lucía Natalia (Elsevier, 2023-06-25)

  The arrhythmogenic cardiomyopathy (ACM) is an inherited heart muscle disease characterized by the progressive replacement of contractile myocardium by fibro-fatty adipose tissue, that generates ventricular arrhythmias and ...

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