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Computational basis of decision-making impairment in multiple sclerosis

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dc.contributor.author Fernández, Rodrigo Sebastián
dc.contributor.author Crivelli, Lucía
dc.contributor.author Pedreira, María Eugenia
dc.contributor.author Allegri, Ricardo Francisco
dc.contributor.author Correale, Jorge
dc.date.accessioned 2022-07-21T17:11:56Z
dc.date.available 2022-07-21T17:11:56Z
dc.date.issued 2021-12-21
dc.identifier.citation Fernández RS, Crivelli L, Pedreira ME, Allegri RF, Correale J. Computational basis of decision-making impairment in multiple sclerosis. Mult Scler. 2022 Jul;28(8):1267-1276. doi: 10.1177/13524585211059308 es_ES
dc.identifier.uri https://doi.org/10.1177/13524585211059308
dc.identifier.uri https://repositorio.fleni.org.ar/xmlui/handle/123456789/635
dc.description.abstract Background: Multiple sclerosis (MS) is commonly associated with decision-making, neurocognitive impairments, and mood and motivational symptoms. However, their relationship may be obscured by traditional scoring methods. Objectives: To study the computational basis underlying decision-making impairments in MS and their interaction with neurocognitive and neuropsychiatric measures. Methods: Twenty-nine MS patients and 26 matched control subjects completed a computer version of the Iowa Gambling Task (IGT). Participants underwent neurocognitive evaluation using an expanded version of the Brief Repeatable Battery. Hierarchical Bayesian Analysis was used to estimate three established computational models to compare parameters between groups. Results: Patients showed increased learning rate and reduced loss-aversion during decision-making relative to control subjects. These alterations were associated with: (1) reduced net gains in the IGT; (2) processing speed, executive functioning and memory impairments; and (3) higher levels of depression and current apathy. Conclusion: Decision-making deficits in MS patients could be described by the interplay between latent computational processes, neurocognitive impairments, and mood/motivational symptoms. es_ES
dc.language.iso eng es_ES
dc.publisher Sage es_ES
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by/2.5/ar/
dc.subject Multiple Sclerosis es_ES
dc.subject Esclerosis Múltiple es_ES
dc.subject Cognitive Impairment es_ES
dc.subject Disfunción Cognitiva es_ES
dc.subject Decision Making es_ES
dc.subject Toma de Decisiones es_ES
dc.subject Neuropsychological Tests es_ES
dc.subject Pruebas Neuropsicológicas es_ES
dc.title Computational basis of decision-making impairment in multiple sclerosis es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.type info:eu-repo/semantics/publishedVersion
dc.description.fil Fil: Fernández, Rodrigo Sebastián. Universidad de Buenos Aires; Argentina.
dc.description.fil Fil: Crivelli, Lucía. Fleni. Departamento de Neurología. Servicio de Neurología Cognitiva, Neuropsicología y Neuropsiquiatría; Argentina.
dc.description.fil Fil: Pedreira, María Eugenia. Universidad de Buenos Aires; Argentina.
dc.description.fil Fil: Allegri, Ricardo Francisco. Fleni. Departamento de Neurología. Servicio de Neurología Cognitiva, Neuropsicología y Neuropsiquiatría; Argentina.
dc.description.fil Fil: Correale, Jorge. Fleni. Departamento de Neurología. Servicio de Neuroinmunología y Enfermedades Desmielinizantes; Argentina.
dc.relation.ispartofVOLUME 28
dc.relation.ispartofNUMBER 8
dc.relation.ispartofPAGINATION 1267-1276
dc.relation.ispartofCOUNTRY Reino Unido
dc.relation.ispartofCITY Londres
dc.relation.ispartofTITLE Multiple sclerosis
dc.relation.ispartofISSN 1477-0970
dc.type.snrd info:ar-repo/semantics/artículo es_ES


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