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Are Brain Responses to Emotion a Reliable Endophenotype of Schizophrenia? An Image-Based Functional Magnetic Resonance Imaging Meta-analysis

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dc.contributor.author Fiorito, Anna M.
dc.contributor.author Aleman, André
dc.contributor.author Blasi, Giuseppe
dc.contributor.author Bourque, Josiane
dc.contributor.author Cao, Hengyi
dc.contributor.author Chan, Raymond C.K.
dc.contributor.author Chowdury, Asadur
dc.contributor.author Conrod, Patricia
dc.contributor.author Diwadkar, Vaibhav A.
dc.contributor.author Goghari, Vina M.
dc.contributor.author Guinjoan, Salvador Martín
dc.contributor.author Gur, Raquel E.
dc.contributor.author Gur, Ruben C.
dc.contributor.author Kwon, Jun Soo
dc.contributor.author Lieslehto, Johannes
dc.contributor.author Lukow, Paulina B.
dc.contributor.author Meyer-Lindenberg, Andreas
dc.contributor.author Modinos, Gemma
dc.contributor.author Quarto, Tiziana
dc.contributor.author Villarreal, Mirta Fabiana
dc.date.accessioned 2022-09-22T15:04:54Z
dc.date.available 2022-09-22T15:04:54Z
dc.date.issued 2022-06-22
dc.identifier.citation Fiorito AM, Aleman A, Blasi G, Bourque J, Cao H, Chan RCK, Chowdury A, Conrod P, Diwadkar VA, Goghari VM, Guinjoan S, Gur RE, Gur RC, Kwon JS, Lieslehto J, Lukow PB, Meyer-Lindenberg A, Modinos G, Quarto T, Spilka MJ, Shivakumar V, Venkatasubramanian G, Villarreal M, Wang Y, Wolf DH, Yun JY, Fakra E, Sescousse G. Are Brain Responses to Emotion a Reliable Endophenotype of Schizophrenia? An Image-Based Functional Magnetic Resonance Imaging Meta-analysis. Biol Psychiatry. 2022 Jun 22:S0006-3223(22)01357-9. doi: 10.1016/j.biopsych.2022.06.013. Epub ahead of print. es_ES
dc.identifier.uri https://repositorio.fleni.org.ar/xmlui/handle/123456789/672
dc.identifier.uri https://doi.org/10.1016/j.biopsych.2022.06.013
dc.description.abstract Background: Impaired emotion processing constitutes a key dimension of schizophrenia and a possible endophenotype of this illness. Empirical studies consistently report poorer emotion recognition performance in patients with schizophrenia as well as in individuals at enhanced risk of schizophrenia. Functional magnetic resonance imaging studies also report consistent patterns of abnormal brain activation in response to emotional stimuli in patients, in particular, decreased amygdala activation. In contrast, brain-level abnormalities in at-risk individuals are more elusive. We address this gap using an image-based meta-analysis of the functional magnetic resonance imaging literature. Methods: Functional magnetic resonance imaging studies investigating brain responses to negative emotional stimuli and reporting a comparison between at-risk individuals and healthy control subjects were identified. Frequentist and Bayesian voxelwise meta-analyses were performed separately, by implementing a random-effect model with unthresholded group-level T-maps from individual studies as input. Results: In total, 17 studies with a cumulative total of 677 at-risk individuals and 805 healthy control subjects were included. Frequentist analyses did not reveal significant differences between at-risk individuals and healthy control subjects. Similar results were observed with Bayesian analyses, which provided strong evidence for the absence of meaningful brain activation differences across the entire brain. Region of interest analyses specifically focusing on the amygdala confirmed the lack of group differences in this region. Conclusions: These results suggest that brain activation patterns in response to emotional stimuli are unlikely to constitute a reliable endophenotype of schizophrenia. We suggest that future studies instead focus on impaired functional connectivity as an alternative and promising endophenotype. es_ES
dc.language.iso eng es_ES
dc.publisher Elsevier es_ES
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by/2.5/ar/
dc.subject Schizophrenia es_ES
dc.subject Esquizofrenia es_ES
dc.subject Magnetic Resonance Imaging es_ES
dc.subject Imagen por Resonancia Magnética es_ES
dc.title Are Brain Responses to Emotion a Reliable Endophenotype of Schizophrenia? An Image-Based Functional Magnetic Resonance Imaging Meta-analysis es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.type info:eu-repo/semantics/publishedVersion
dc.description.fil Fil: Villarreal, Mirta Fabiana. Instituto de Neurociencias FLENI-CONICET; Argentina.
dc.description.fil Fil: Fiorito, Anna M. University of Lyon; Francia. University Hospital of Saint-Etienne, Saint-Etienne. Department of Psychiatry; Francia.
dc.description.fil Fil: Aleman, André. University of Groningen; Países Bajos. University Medical Center Groningen. Department of Biomedical Sciences of Cells & Systems; Países Bajos.
dc.description.fil Fil: Blasi, Giuseppe. University of Bari Aldo Moro. Department of Basic Medical Sciences, Neuroscience and Sense Organs. Group of Psychiatric Neuroscience; Italia.
dc.description.fil Fil: Bourque, Josiane. University of Pennsylvania. Perelman School of Medicine. Department of Psychiatry; Estados Unidos.
dc.description.fil Fil: Cao, Hengyi. Feinstein Institute for Medical Research. Center for Psychiatric Neuroscience; Estados Unidos.
dc.description.fil Fil: Chan, Raymond C.K. Institute of Psychology. Sciences Key Laboratory of Mental Health; China.
dc.description.fil Fil: Chowdury, Asadur. Wayne State University. Department of Psychiatry & Behavioral Neurosciences; Estados Unidos.
dc.description.fil Fil: Conrod, Patricia. University of Montréal. Department of Psychiatry and Addiction. CHU Sainte-Justine Research Center; Canadá.
dc.description.fil Fil: Diwadkar, Vaibhav A. University of Montréal. Department of Psychiatry and Addiction. CHU Sainte-Justine Research Center; Canadá.
dc.description.fil Fil: Goghari, Vina M. University of Toronto. Department of Psychological Clinical Science; Canadá.
dc.description.fil Fil: Guinjoan, Salvador Martín. Laureate Institute for Brain Research; Estados Unidos.
dc.description.fil Fil: Gur, Raquel E. University of Pennsylvania. Department of Psychiatry, Perelman School of Medicine; Estados Unidos.
dc.description.fil Fil: Gur, Ruben C. University of Pennsylvania. Department of Psychiatry, Perelman School of Medicine; Estados Unidos.
dc.description.fil Fil: Kwon, Jun Soo. Seoul National University College of Medicine. Department of Psychiatry; Corea.
dc.description.fil Fil: Lieslehto, Johannes. Niuvanniemi Hospital. University of Eastern Finland, Department of Forensic Psychiatry; Finlandia.
dc.description.fil Fil: Lukow, Paulina B. King's College London. Institute of Psychiatry, Psychology & Neuroscience. Department of Psychosis Studies; Reino Unido.
dc.description.fil Fil: Meyer-Lindenberg, Andreas. Medical Faculty Mannheim/Heidelberg University. Central Institute of Mental Health; Alemania.
dc.description.fil Fil: Modinos, Gemma. King's College London. Institute of Psychiatry, Psychology & Neuroscience. Department of Psychosis Studies; Reino Unido.
dc.description.fil Fil: Quarto, Tiziana. University of Foggia. Department of Law; Italia.
dc.relation.ispartofPAGINATION S0006-3223(22)01357-9
dc.relation.ispartofCOUNTRY Estados Unidos
dc.relation.ispartofCITY Nueva York
dc.relation.ispartofTITLE Biological psychiatry
dc.relation.ispartofISSN 1873-2402
dc.type.snrd info:ar-repo/semantics/artículo es_ES


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