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Connectivity and Patterns of Regional Cerebral Blood Flow, Cerebral Glucose Uptake, and Aβ-Amyloid Deposition in Alzheimer's Disease (Early and Late-Onset) Compared to Normal Ageing

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dc.contributor.author Falasco, Germán
dc.contributor.author Damián, Andrés
dc.contributor.author Urrutia, Leandro
dc.contributor.author Niell, Nicolás
dc.contributor.author Lago, Graciela
dc.contributor.author Bérgamo, Yanina
dc.contributor.author Chrem Méndez, Patricio Alexis
dc.contributor.author Quagliata, Adriana
dc.contributor.author Bentancourt, Cecilia
dc.contributor.author Calandri, Ismael Luis
dc.contributor.author Cordero, Ismael
dc.contributor.author Ponce de León, Magdalena
dc.contributor.author Contreras, Valeria
dc.contributor.author Feuerstein, Viviana
dc.contributor.author Dansilio, Sergio
dc.contributor.author Allegri, Ricardo Francisco
dc.contributor.author Engler, Henry
dc.contributor.author Vázquez, Silvia
dc.date.accessioned 2022-11-10T18:09:31Z
dc.date.available 2022-11-10T18:09:31Z
dc.date.issued 2021-11-15
dc.identifier.citation Falasco G, Andrés D, Leandro U, Nicolás N, Graciela L, Yanina B, Patricio C, Adriana Q, Cecilia B, Ismael C, Ismael C, de León MP, Valeria C, Feuerstein V, Sergio D, Ricardo A, Henry E, Silvia V. Connectivity and Patterns of Regional Cerebral Blood Flow, Cerebral Glucose Uptake, and Aβ-Amyloid Deposition in Alzheimer's Disease (Early and Late-Onset) Compared to Normal Ageing. Curr Alzheimer Res. 2021;18(8):646-655. doi: 10.2174/1567205018666211116095035 es_ES
dc.identifier.uri https://doi.org/10.2174/1567205018666211116095035
dc.identifier.uri https://repositorio.fleni.org.ar/xmlui/handle/123456789/717
dc.description.abstract Purpose: The aim of this study was to investigate the differences in early (EOAD) and late (LOAD) onset of Alzheimer´s disease, as well as glucose uptake, regional cerebral blood flow (R1), amyloid depositions, and functional brain connectivity between normal young (YC) and Old Controls (OC). Methodology: The study included 22 YC (37 ± 5 y), 22 OC (73 ± 5.9 y), 18 patients with EOAD (63 ± 9.5 y), and 18 with LOAD (70.6 ± 7.1 y). Patients underwent FDG and PIB PET/CT. R1 images were obtained from the compartmental analysis of the dynamic PIB acquisitions. Images were analyzed by a voxel-wise and a VOI-based approach. Functional connectivity was studied from the R1 and glucose uptake images. Results: OC had a significant reduction of R1 and glucose uptake compared to YC, predominantly at the dorsolateral and mesial frontal cortex. EOAD and LOAD vs. OC showed a decreased R1 and glucose uptake at the posterior parietal cortex, precuneus, and posterior cingulum. EOAD vs. LOAD showed a reduction in glucose uptake and R1 at the occipital and parietal cortex and an increased at the mesial frontal and temporal cortex. There was a mild increase in an amyloid deposition at the frontal cortex in LOAD vs. EOAD. YC presented higher connectivity than OC in R1 but lower connectivity considering glucose uptake. Moreover, EOAD and LOAD showed a decreased connectivity compared to controls that were more pronounced in glucose uptake than R1. Conclusion: Our results demonstrated differences in amyloid deposition and functional imaging between groups and a differential pattern of functional connectivity in R1 and glucose uptake in each clinical condition. These findings provide new insights into the pathophysiological processes of AD and may have an impact on patient diagnostic evaluation. es_ES
dc.language.iso eng es_ES
dc.publisher Bentham Science Publishers es_ES
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by/2.5/ar/
dc.subject Alzheimer Disease es_ES
dc.subject Enfermedad de alzheimer es_ES
dc.subject Aniline Compounds es_ES
dc.subject Compuestos de Anilina es_ES
dc.subject Cerebrovascular Circulation es_ES
dc.subject Circulación Cerebrovascular es_ES
dc.subject Glucose es_ES
dc.subject Glucosa es_ES
dc.subject Positron Emission Tomography Computed Tomography es_ES
dc.subject Tomografía Computarizada por Tomografía de Emisión de Positrones es_ES
dc.title Connectivity and Patterns of Regional Cerebral Blood Flow, Cerebral Glucose Uptake, and Aβ-Amyloid Deposition in Alzheimer's Disease (Early and Late-Onset) Compared to Normal Ageing es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.type info:eu-repo/semantics/publishedVersion
dc.description.fil Fil: Falasco, Germán. Fleni. Departamento de Diagnóstico por Imágenes. Centro de Imágenes Moleculares; Argentina.
dc.description.fil Fil: Damián, Andrés. Centro Uruguayo de Imagenologia Molecular; Uruguay.
dc.description.fil Fil: Urrutia, Leandro. Fleni. Departamento de Diagnóstico por Imágenes. Centro de Imágenes Moleculares; Argentina.
dc.description.fil Fil: Niell, Nicolás. Centro Uruguayo de Imagenologia Molecular; Uruguay.
dc.description.fil Fil: Lago, Graciela. Centro Uruguayo de Imagenologia Molecular; Uruguay.
dc.description.fil Fil: Bérgamo, Yanina. Fleni. Departamento de Neurología. Servicio de Neurología Cognitiva, Neuropsicología y Neuropsiquiatría; Argentina.
dc.description.fil Fil: Chrem Méndez, Patricio Alexis. Fleni. Departamento de Neurología. Servicio de Neurología Cognitiva, Neuropsicología y Neuropsiquiatría; Argentina.
dc.description.fil Fil: Quagliata, Adriana. Centro Uruguayo de Imagenologia Molecular; Uruguay.
dc.description.fil Fil: Bentancourt, Cecilia. Centro Uruguayo de Imagenologia Molecular; Uruguay.
dc.description.fil Fil: Calandri, Ismael Luis. Fleni. Departamento de Neurología. Servicio de Neurología Cognitiva, Neuropsicología y Neuropsiquiatría; Argentina.
dc.description.fil Fil: Cordero, Ismael. Centro Uruguayo de Imagenologia Molecular; Uruguay.
dc.description.fil Fil: Ponce de León, Magdalena. Fleni. Departamento de Diagnóstico por Imágenes. Centro de Imágenes Moleculares; Argentina.
dc.description.fil Fil: Contreras, Valeria. Hospital de Clínicas; Uruguay.
dc.description.fil Fil: Feuerstein, Viviana. Hospital de Clínicas; Uruguay.
dc.description.fil Fil: Dansilio, Sergio. Hospital de Clínicas; Uruguay.
dc.description.fil Fil: Allegri, Ricardo Francisco. Fleni. Departamento de Neurología. Servicio de Neurología Cognitiva, Neuropsicología y Neuropsiquiatría; Argentina.
dc.description.fil Fil: Engler, Henry. Universidad de la República; Uruguay.
dc.description.fil Fil: Vázquez, Silvia. Fleni. Departamento de Diagnóstico por Imágenes. Centro de Imágenes Moleculares; Argentina.
dc.relation.ispartofVOLUME 18
dc.relation.ispartofNUMBER 8
dc.relation.ispartofPAGINATION 646-655
dc.relation.ispartofCOUNTRY Estados Unidos
dc.relation.ispartofCITY San Francisco
dc.relation.ispartofTITLE Current Alzheimer research
dc.relation.ispartofISSN 1875-5828
dc.type.snrd info:ar-repo/semantics/artículo es_ES


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