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Oculomotor Abnormalities during Reading in the Offspring of Late-Onset Alzheimer's Disease

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dc.contributor.author Fernández, Gerardo
dc.contributor.author González, Ana Paula
dc.contributor.author Abulafia, Carolina
dc.contributor.author Fiorentini, Leticia
dc.contributor.author Agamennoni, Osvaldo
dc.contributor.author Guinjoan, Salvador Martín
dc.date.accessioned 2023-01-09T11:42:14Z
dc.date.available 2023-01-09T11:42:14Z
dc.date.issued 2022
dc.identifier.citation Fernández G, González AP, Abulafia C, Fiorentini L, Agamennoni O, Guinjoan SM. Oculomotor Abnormalities during Reading in the Offspring of Late-Onset Alzheimer's Disease. Curr Alzheimer Res. 2022;19(3):212-222. doi: 10.2174/1567205019666220413075840. es_ES
dc.identifier.uri https://doi.org/10.2174/1567205019666220413075840
dc.identifier.uri https://repositorio.fleni.org.ar/xmlui/handle/123456789/765
dc.description.abstract Introduction: Eye movement patterns during reading are well defined and documented. Each eye movement ends up in a fixation point, which allows the brain to process the incoming information and program the following saccade. In this work, we investigated whether eye movement alterations during a reading task might be already present in middle-aged, cognitively normal offspring of late-onset Alzheimer's disease (O-LOAD). Methods: 18 O-LOAD and 18 age-matched healthy individuals with no family history of LOAD participated in the study. Participants were seated in front of a 20-inch LCD monitor, and single sentences were presented on it. Eye movements were recorded with an eye tracker with a sampling rate of 1000 Hz. Results: Analysis of eye movements during reading revealed that O-LOAD displayed more fixations, shorter saccades, and shorter fixation durations than controls. Conclusion: The present study shows that O-LOAD experienced alterations in their eye movements during reading. O-LOAD eye movement behavior could be considered an initial sign of oculomotor impairment. Hence, the evaluation of eye movement during reading might be a useful tool for monitoring well-defined cognitive resources. es_ES
dc.language.iso eng es_ES
dc.publisher Bentham Science Publishers es_ES
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by/2.5/ar/
dc.subject Alzheimer Disease es_ES
dc.subject Enfermedad de Alzheimer es_ES
dc.title Oculomotor Abnormalities during Reading in the Offspring of Late-Onset Alzheimer's Disease es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.type info:eu-repo/semantics/publishedVersion
dc.description.fil Fil: Fernández, Gerardo. ViewMind Inc; Estados Unidos. IIIE-CONICET; Argentina.
dc.description.fil Fil: González, Ana Paula. Fleni. Instituto de Neurociencias FLENI-CONICET. Grupo de Investigación en Neurociencias Aplicadas a las Alteraciones de la Conducta; Argentina.
dc.description.fil Fil: Abulafia, Carolina. Fleni. Instituto de Neurociencias FLENI-CONICET. Grupo de Investigación en Neurociencias Aplicadas a las Alteraciones de la Conducta; Argentina. Fleni. Departamento de Neurología. Servicio de Psiquiatría; Argentina. Universidad Católica Argentina; Argentina.
dc.description.fil Fil: Fiorentini, Leticia. Fleni. Instituto de Neurociencias FLENI-CONICET. Grupo de Investigación en Neurociencias Aplicadas a las Alteraciones de la Conducta; Argentina. Fleni. Departamento de Neurología. Servicio de Psiquiatría; Argentina.
dc.description.fil Fil: Agamennoni, Osvaldo. IIIE-CONICET; Argentina.
dc.description.fil Fil: Guinjoan, Salvador Martín. Fleni. Servicio de Psiquiatría; Argentina.
dc.relation.ispartofVOLUME 19
dc.relation.ispartofNUMBER 3
dc.relation.ispartofPAGINATION 212-222.
dc.relation.ispartofCOUNTRY Estados Unidos
dc.relation.ispartofCITY San Francisco
dc.relation.ispartofTITLE Current Alzheimer research
dc.relation.ispartofISSN 1875-5828
dc.type.snrd info:ar-repo/semantics/artículo es_ES


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