DSpace Repositorium (Manakin basiert)

Improvement of episodic memory retention by a memory reactivation intervention across the lifespan: from younger adults to amnesic patients

Zur Kurzanzeige

dc.contributor.author Fernández, Rodrigo Sebastián
dc.contributor.author Picco, Soledad
dc.contributor.author Beron, Juan Cruz
dc.contributor.author Bavassi, Luz
dc.contributor.author Campos, Jorge
dc.contributor.author Allegri, Ricardo Francisco
dc.contributor.author Pedreira, María Eugenia
dc.date.accessioned 2023-01-11T12:29:39Z
dc.date.available 2023-01-11T12:29:39Z
dc.date.issued 2022-04-05
dc.identifier.citation Fernández RS, Picco S, Beron JC, Bavassi L, Campos J, Allegri RF, Pedreira ME. Improvement of episodic memory retention by a memory reactivation intervention across the lifespan: from younger adults to amnesic patients. Transl Psychiatry. 2022 Apr 5;12(1):144. doi: 10.1038/s41398-022-01915-z. es_ES
dc.identifier.uri https://doi.org/10.1038/s41398-022-01915-z
dc.identifier.uri https://repositorio.fleni.org.ar/xmlui/handle/123456789/769
dc.description.abstract Spontaneous reactivation of recently acquired memories is a fundamental mechanism of memory stabilization. Re-exposure to specific learned cues during sleep or awake states, namely targeted memory reactivation, has been shown to improve memory retention at long delays. Manipulation of memory reactivation could have potential clinical value in populations with memory deficits or cognitive decline. However, no previous study investigated a target memory reactivation approach on those populations. Here we tested the hypothesis that a reactivation-based intervention would improve episodic memory performance in healthy adults and amnestic patients. On Day 1, young adults, old adults and amnestic Mild Cognitive Impairment patients (n = 150) learned face-name pairs and 24 h later either received a reactivation intervention or a reactivation control (Day 2). On Day 3, associative and item memory were assessed. A robust Bayesian Generalized Mixed Model was implemented to estimate intervention effects on groups. Groups that underwent the reactivation-based intervention showed improved associative memory retention. Notably, amnestic patients benefited more from the intervention as they also had better item memory retention than controls. These findings support memory reactivation as stabilization and strengthening mechanism irrespectively of age and cognitive status, and provides proof-of-concept evidence that reactivation-based interventions could be implemented in the treatment and rehabilitation of populations with memory deficits. es_ES
dc.language.iso eng es_ES
dc.publisher Nature Pub. Group es_ES
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by/2.5/ar/
dc.subject Memory es_ES
dc.subject Memoria es_ES
dc.subject Public Health es_ES
dc.subject Salud Pública es_ES
dc.title Improvement of episodic memory retention by a memory reactivation intervention across the lifespan: from younger adults to amnesic patients es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.type info:eu-repo/semantics/publishedVersion
dc.description.fil Fil: Fernández, Rodrigo Sebastián. Instituto de Fisiología, Biología Molecular y Neurociencias (IFIBYNE - CONICET); Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
dc.description.fil Fil: Picco, Soledad. Instituto de Fisiología, Biología Molecular y Neurociencias (IFIBYNE - CONICET); Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
dc.description.fil Fil: Beron, Juan Cruz. Instituto de Fisiología, Biología Molecular y Neurociencias (IFIBYNE - CONICET); Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
dc.description.fil Fil: Bavassi, Luz. Instituto de Fisiología, Biología Molecular y Neurociencias (IFIBYNE - CONICET); Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
dc.description.fil Fil: Campos, Jorge. Fleni. Departamento de Neurología. Servicio de Neurología Cognitiva, Neuropsicología y Neuropsiquiatría. Centro de Memoria y Envejecimiento; Argentina.
dc.description.fil Fil: Allegri, Ricardo Francisco. Fleni. Departamento de Neurología. Servicio de Neurología Cognitiva, Neuropsicología y Neuropsiquiatría. Centro de Memoria y Envejecimiento; Argentina.
dc.description.fil Fil: Pedreira, María Eugenia. Instituto de Fisiología, Biología Molecular y Neurociencias (IFIBYNE - CONICET); Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
dc.relation.ispartofVOLUME 12
dc.relation.ispartofNUMBER 1
dc.relation.ispartofPAGINATION 144.
dc.relation.ispartofCOUNTRY Estados Unidos
dc.relation.ispartofCITY Nueva York
dc.relation.ispartofTITLE Translational psychiatry
dc.relation.ispartofISSN 2158-3188
dc.type.snrd info:ar-repo/semantics/artículo es_ES


Dateien zu dieser Ressource

Das Dokument erscheint in:

Zur Kurzanzeige

info:eu-repo/semantics/openAccess Solange nicht anders angezeigt, wird die Lizenz wie folgt beschrieben: info:eu-repo/semantics/openAccess

DSpace Suche


Stöbern

Mein Benutzerkonto

Statistik