• Thyrotropin Modulates Calcium Handling and Contractility in Adult Cardiac Myocytes 

  Sepúlveda, Marisa; Racioppi, Florencia; Burgos, Juan Ignacio; Murillo, Alexandra; Fernandez-Ruocco, Julieta; Gonano, Luis; Neiman, Gabriel; Miriuka, Santiago Gabriel; Fellet, Andrea; Casis, Oscar; Medei, Emiliano; Colareda, German; Vila Petroff, Martín (Elsevier, 2025-10-15)

  Hypothyroidism is an independent risk factor for cardiovascular disease and, if chronically sustained, leads to myocardial contractile dysfunction resulting in heart failure. However, the subcellular mechanisms underlying ...
• Comparative diagnostic performance of artificial intelligence models in structural MRI for schizophrenia: A systematic review and meta-analysis 

  Kotochinsky, Martin; Oliveira Fonseca, Pandora Eloa; Ramirez Lopera, Veronica; Mora, Laura; Wellgner Fernandes Oliveira, Amador; Cesar Teixeira Sirena, Eduardo; Bandeira de Melo Guimarães, Felipe; Lahitou Herlyn, Delfina; Norbu Sherpa, Nima; Gonzalez Lezana, Andrea; Pardini Fagundes, Thales (Elsevier, 2025-11-04)

  Introduction: Timely diagnosis of schizophrenia is essential to ensure prompt treatment initiation and adherence. Structural magnetic resonance imaging (sMRI), when combined with artificial intelligence (AI), offers a ...
• Clinical and functional evidence supporting the pathogenicity of the novel PSEN1 p.R358P variant in early-onset Alzheimer's disease 

  García Chialva, Diego; Itzcovich, Tatiana; Cifarelli, Diego; Apecetche, Manuela; Chrem Méndez, Patricio; Magrath Guimet, Nahuel; Vázquez, Silvia; Bérgamo, Yanina; Allegri, Ricardo Francisco; Marazita, Mariela; Sevlever, Gustavo Emilio; Isaja, Luciana; Surace, Ezequiel Ignacio; Romorini, Leonardo (Sage, 2025-11-06)

  BackgroundPathogenic variants in PSEN1, PSEN2, or AβPP cause early-onset Alzheimer's disease (EOAD). Several novel variants remain of uncertain significance (VUS) due to limited evidence. The PSEN1 p.R358P variant has not ...
• HIV infection drives proinflammatory adipocyte differentiation in an in vitro model and reveals a new inflammatory pathway 

  Freiberger, Rosa Nicole; López, Cynthia Alicia Marcela; Sviercz, Franco Agustin; Jarmoluk, Patricio; Palma, María Belén; García, Marcela Nilda; Quarleri, Jorge; Delpino, M. Victoria (Frontiers Media, 2025-07-17)

  Introduction: Adipose tissue regulates metabolic homeostasis and serves as a reservoir for mesenchymal stem cells (MSCs), which differentiate into osteoblasts and adipocytes, balancing bone and lipid metabolism. Bone loss ...
• Formación en Neuropsicología Clínica en Argentina: Creación de la Primera Residencia en Neuropsicología de Adultos en Fleni 

  Clarens, María Florencia; Morello García, Florentina; De Los Santos, Loana; Martin, María Eugenia; Sevlever, Gustavo Emilio; Crivelli, Lucía (Universidad de la Costa, 2025-07-21)

  La neuropsicología en Argentina cuenta con una trayectoria sólida, iniciada con estudios tempranos sobre trastornos del lenguaje a comienzos del siglo XX. A pesar de que el contexto sociopolítico ...
• Multi-Channel Nuclear Analysis: An ImageJ/FIJI Plugin for Automated Nuclear Segmentation and Multi-Channel Fluorescence Analysis 

  Waisman, Ariel (Caltech Library, 2025)

  Quantitative analysis of fluorescence microscopy images is essential for studying expression levels, subcellular localization and co-occurrence of proteins and other biomolecules. While several automated tools exist for ...
• Molecular mechanism underlying alcohol's residual effects: The role of acetaldehyde in mitochondrial dysfunction at synapses in mouse brain cortex 

  Karadayian, Analía G.; Carrere, Lautaro; Czerniczyniec, Analia; Lores-Arnaiz, Silvia (Elsevier, 2025-09-17)

  Alcohol residual effects impose significant physiological and cognitive burdens due to acute ethanol exposure; however, its underlying mechanisms remain poorly understood. This study investigates the role of acetaldehyde, ...
• A journey through genetic movement disorders caused by non-coding repeat expansions 

  Pinheiro Camurugy da Hora, Raphael; Rossi, Malco Damián; Rebelo Procaci, Victor; Yoshinaga Tonholo Silva, Thiago; Alves Corazza, Luiza; Novis, Luiz Eduardo; Barsottini, Orlando G.; Pedroso, José Luiz (Elsevier, 2025-07-21)

  Nucleotide repeat expansions are a key genetic mechanism underlying various neurological disorders, especially in movement disorders. While many expansion-related conditions are caused by variants in coding regions, an ...
• "Susceptibility of hiPSC-derived NSCs and neurons to paraquat treatment: insights into differential neurotoxicity mechanisms related to mitochondria." 

  Czerniczyniec, Analia; Mucci, Sofía; Lopez, M.A.; Apecetche, Manuela; García Chialva, Diego; Quilumbaquin, W.; Marazita, Mariela Claudia; Sevlever, Gustavo Emilio; Scassa, María Élida; Vanasco, V.; Romorini, Leonardo (Elsevier, 2025-09-13)

  Environmental exposure to paraquat (PQ), a widely used herbicide, has been associated with an increased risk of neurodegenerative diseases such as Parkinson's disease. However, species-specific limitations of traditional ...
• Generation of an iPSC line from congenital hypopituitarism patient with a nonsense heterozygous variant in FOXA2 

  Camilletti, María Andrea; Chirino Felker, Gonzalo Tomás; Castañeda, Sheila; Zabalegui, Federico; Amin, Guadalupe; Belgorosky, Alicia; Ciaccio, Marta; Di Palma, Maria Isabel; Vaiani, Elisa; Waisman, Ariel; Miriuka, Santiago Gabriel; Pérez Millán, María Inés; Moro, Lucia Natalia (Elsevier, 2025-07-15)

  Forkhead box A2 (FOXA2) is a pioneer transcription factor, necessary for human development. Mutations in FOXA2 were recently associated with congenital hypopituitarism (CH); however, the pathogenic mechanism remains unknown. ...
• Integrated Workflow for Drug Repurposing in Glioblastoma: Computational Prediction and Preclinical Validation of Therapeutic Candidates 

  Gonzalez, Nazareno; Pérez Küper, Melanie; Garcia Fallit, Matías; Peña Agudelo, Jorge A.; Candia, Alejandro Nicola; Suarez Velandia, Maicol; Romero, Ana Clara; Videla Richardson, Guillermo Agustín; Candolfi, Marianela (MDPI, 2025-06-13)

  Background: Glioblastoma (GBM) remains a significant challenge in oncology due to its resistance to standard treatments including temozolomide. This study aimed to develop and validate an integrated model for predicting ...
• Targeting FOXP3 in glioblastoma: Blockade of tumor intrinsic effects boosts response to chemo-radiotherapy 

  Garcia Fallit, Matías; Peña Agudelo, Jorge A.; Nicola Candia, Alejandro J.; Gonzalez, Nazareno; Pérez Küper, Melanie; Zampini, Yamila; Romero, Ana Clara; Sobarzo, Cristian; Sánchez Rojas, Ivana; Durán, Hebe; Perona, Marina; Ripari, Luisina Belén; Videla Richardson, Guillermo Agustín; Zanetti, Flavia A.; Lozano, Teresa; Casares, Noelia; Lasarte, Juan José; Candolfi, Marianela (Elsevier, 2025-06-27)

  Glioblastoma (GBM) is the most common malignant primary brain tumor in adults. Although this disease carries a dismal prognosis due to its highly invasive nature and resistance to therapy, no significant therapeutic advances ...
• Generation of human induced pluripotent stem cell lines from two down syndrome patients, including a down syndrome/Alzheimer's disease case (FLENIi002-A) and a beta-amyloid-resistant case (FLENIi003-A) 

  Clas, Giulia Solange; Marazita, Mariela Claudia; Pertierra, Lucía; Vázquez, Silvia; Isaja, Luciana; Rodríguez Varela, María Soledad; Mucci, Sofía; Helou, María Belén; Tapajóz Pereira de Sampaio, Fernanda; Magrath Guimet, Nahuel; Bérgamo, Yanina; Allegri, Ricardo Francisco; Sevlever, Gustavo Emilio; Scassa, María Élida; Surace, Ezequiel Ignacio; Romorini, Leonardo (Elsevier, 2025-05-01)

  Two human induced pluripotent stem cell (hiPSC) lines, FLENIi002-A and FLENIi003-A, were generated from peripheral blood mononuclear cells (PBMCs) using the lentiviral-hSTEMCCA-loxP vector. FLENIi002-A was derived from a ...
• Resistance and resilience to Alzheimer's disease in Down syndrome 

  Boyle, Rory; Koops, Elouise A.; Ances, Beau; Andrews, Elizabeth J.; Arenaza-Urquijo, Eider M.; Benjanin, Alexandre; Brickman, Adam M.; Buckley, Rachel F.; Clas, Giulia Solange; Costello, Emmet; Coughlan, Gillian T.; Conley, Alexander C.; Deng, Feng; de Paula Faria, Daniele; Edwards, Natalie; Flores-Aguilar, Lisi; Fortea, Juan; Saidi, Ladan Ghazi; Head, Elizabeth; Hom, Christy L. (Wiley, 2025-04-28)

  Due to the high prevalence of Alzheimer's disease (AD) in adults with Down syndrome (DS), trisomy 21 is now considered a genetic form of AD (DSAD). A better understanding of factors that can prevent or delay AD is vital ...
• SARS-CoV-2 Impairs Osteoblast Differentiation Through Spike Glycoprotein and Cytokine Dysregulation 

  Freiberger, Rosa Nicole; López, Cynthia Alicia Marcela; Jarmoluk, Patricio; Palma, María Belén; Cevallos, Cintia; Sviercz, Franco Agustin; Grosso, Tomás Martín; García, Marcela Nilda; Quarleri, Jorge; Delpino, María Victoria (MDPI, 2025-01-22)

  Pulmonary and extrapulmonary manifestations have been reported following infection with SARS-CoV-2, the causative agent of COVID-19. The virus persists in multiple organs due to its tropism for various tissues, including ...
• Exploring Music-Based Interventions for Executive Functioning and Emotional Well-Being in Stroke Rehabilitation: A Scoping Review 

  Pfeiffer, Camila Floreana; Magee, Wendy L.; Fülöp, Rebecca; Nace, Travis C.; Castro, Candela; Iturri, Agustina; Franceschi, Jimena; Echauri, Gabriela; Gassull, Liliana; Russo, María Julieta (MDPI, 2024-10-27)

  Purpose: Stroke is one of the leading causes of disability with life-long implications requiring assessment and treatment of several functional domains. This review identifies the results from research into music-based ...
• Advancing biobanking in Latin America: success stories and challenges ahead 

  Sevlever, Gustavo Emilio; Crivelli, Lucía; Kimie Suemoto, Claudia; Surace, Ezequiel Ignacio; Taratuto, Ana Lía (Elsevier, 2025-03-03)

  Resumen no disponible
• Validation of an Artificial Intelligence-Powered Virtual Assistant for Emergency Triage in Neurology 

  Alessandro, Lucas; Crema, Santiago; Castiglione, Juan Ignacio; Dossi, Daiana Elizabeth; Eberbach, Federico; Kohler, Alejandro Alfredo; Laffue, Alfredo Hernan; Marone, Abril; Nagel, Vanesa; Pastor Rueda, José Manuel; Varela, Francisco José; Fernández Slezak, Diego; Rodríguez Murúa, Sofía; Debasa, Carlos; Pensa, Claudio; Farez, Mauricio Franco (Lippincott Williams & Wilkins, 2025-02-06)

  Objectives: Neurological emergencies pose significant challenges in medical care in resource-limited countries. Artificial intelligence (AI), particularly health chatbots, offers a promising solution. Rigorous validation ...
• Ideas erróneas sobre daño cerebral adquirido en población de la Ciudad Autónoma de Buenos Aires 

  Tabernero, María Eugenia; Leonardelli, Eduardo; Gallo, María Fernanda; Cores, Evangelina Valeria; Deschle, Florencia (Elsevier, 2024-10-10)

  Introducción Diversas investigaciones han demostrado la existencia de ideas erróneas sobre daño cerebral adquirido (ieDCA) y sus consecuencias en diferentes poblaciones. Objetivo Describir la presencia de ieDCA en ...
• CSF proteomics identifies early changes in autosomal dominant Alzheimer's disease 

  Shen, Yuanyuan; Timsina, Jigyasha; Heo, Gyujin; Beric, Aleksandra; Ali, Muhammad; Wang, Ciyang; Yang, Chengran; Wang, Yueyao; Western, Daniel; Liu, Menghan; Gorijala, Priyanka; Budde, John P.; Do, Anh; Liu, Haiyan; Gordon, Brian A.; Llibre Guerra, Jorge J.; Surace, Ezequiel Ignacio; Allegri, Ricardo Francisco; Dominantly Inherited Alzheimer Network (Cell Press, 2024-09-26)

  In this high-throughput proteomic study of autosomal dominant Alzheimer's disease (ADAD), we sought to identify early biomarkers in cerebrospinal fluid (CSF) for disease monitoring and treatment strategies. We examined CSF ...

View more