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Cross-sectional and longitudinal comparisons of biomarkers and cognition among asymptomatic middle-aged individuals with a parental history of either autosomal dominant or late-onset Alzheimer's disease

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dc.contributor.author Xiong, Chengjie
dc.contributor.author McCue, Lena M.
dc.contributor.author Buckles, Virginia
dc.contributor.author Grant, Elizabeth
dc.contributor.author Agboola, Folasade
dc.contributor.author Coble, Dean
dc.contributor.author Bateman, Randall J.
dc.contributor.author Fagan, Anne M.
dc.contributor.author Benzinger, Tammie L.S.
dc.contributor.author Hassenstab, Jason
dc.contributor.author Schindler, Suzanne E.
dc.contributor.author McDade, Eric
dc.contributor.author Moulder, Krista L.
dc.contributor.author Gordon, Brian A.
dc.contributor.author Cruchaga, Carlos
dc.contributor.author Day, Gregory S.
dc.contributor.author Ikeuchi, Takeshi
dc.contributor.author Suzuki, Kazushi
dc.contributor.author Allegri, Ricardo Francisco
dc.contributor.author Dominantly Inherited Alzheimer Network
dc.date.accessioned 2023-09-07T13:45:00Z
dc.date.available 2023-09-07T13:45:00Z
dc.date.issued 2023-01-14
dc.identifier.citation Xiong C, McCue LM, Buckles V, Grant E, Agboola F, Coble D, Bateman RJ, Fagan AM, Benzinger TLS, Hassenstab J, Schindler SE, McDade E, Moulder KL, Gordon BA, Cruchaga C, Day GS, Ikeuchi T, Suzuki K, Allegri RF, Vöglein J, Levin J, Morris JC; Dominantly Inherited Alzheimer Network (DIAN). Cross-sectional and longitudinal comparisons of biomarkers and cognition among asymptomatic middle-aged individuals with a parental history of either autosomal dominant or late-onset Alzheimer's disease. Alzheimers Dement. 2023 Jul;19(7):2923-2932. doi: 10.1002/alz.12912. es_ES
dc.identifier.uri https://doi.org/10.1002/alz.12912
dc.identifier.uri https://repositorio.fleni.org.ar/xmlui/handle/123456789/826
dc.description.abstract Background: Comparisons of late-onset Alzheimer's disease (LOAD) and autosomal dominant AD (ADAD) are confounded by age. Methods: We compared biomarkers from cerebrospinal fluid (CSF), magnetic resonance imaging, and amyloid imaging with Pittsburgh Compound-B (PiB) across four groups of 387 cognitively normal participants, 42 to 65 years of age, in the Dominantly Inherited Alzheimer Network (DIAN) and the Adult Children Study (ACS) of LOAD: DIAN mutation carriers (MCs) and non-carriers (NON-MCs), and ACS participants with a positive (FH+) and negative (FH-) family history of LOAD. Results: At baseline, MCs had the lowest age-adjusted level of CSF Aβ42 and the highest levels of total and phosphorylated tau-181, and PiB uptake. Longitudinally, MC had similar increase in PiB uptake to FH+, but drastically faster decline in hippocampal volume than others, and was the only group showing cognitive decline. Discussion: Preclinical ADAD and LOAD share many biomarker signatures, but cross-sectional and longitudinal differences may exist. es_ES
dc.language.iso eng es_ES
dc.publisher Wiley es_ES
dc.subject Alzheimer Disease es_ES
dc.subject Enfermedad de Alzheimer es_ES
dc.subject Amyloid beta-Peptides es_ES
dc.subject Péptidos beta-Amiloides es_ES
dc.subject Positron-Emission Tomography es_ES
dc.subject Tomografía de Emisión de Positrones es_ES
dc.title Cross-sectional and longitudinal comparisons of biomarkers and cognition among asymptomatic middle-aged individuals with a parental history of either autosomal dominant or late-onset Alzheimer's disease es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.description.fil Fil: Allegri, Ricardo Francisco. Fleni. Departamento de Neurología. Servicio de Neurología Cognitiva, Neuropsicología y Neuropsiquiatría; Argentina.
dc.relation.ispartofVOLUME 19
dc.relation.ispartofNUMBER 7
dc.relation.ispartofPAGINATION 2923-2932
dc.relation.ispartofCOUNTRY Estados Unidos
dc.relation.ispartofCITY Hoboken
dc.relation.ispartofTITLE Alzheimer's & dementia
dc.relation.ispartofISSN 1552-5279
dc.type.snrd info:ar-repo/semantics/artículo es_ES


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