Repositorio Institucional Fleni

El Repositorio Institucional Fleni tiene el objetivo reunir, almacenar, preservar y difundir la producción científico-académica de la Institución producto de sus actividades de investigación y docencia, a fin de ponerlas a disposición de la comunidad para su uso, tendiendo a aumentar la visibilidad y la difusión de los documentos generados y colaborar así en la construcción de su memoria institucional.

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Recently Added

  • Factors for Rituximab Refractoriness in AQP4-IgG+ NMOSD: A Cohort Study 
    Marrodán, Mariano; Piedrabuena, María Agustina; Zárate, María Agustina; Rodríguez Murúa, Sofía; Surace, Ezequiel Ignacio; Farez, Mauricio Franco; Fiol, Marcela Paula; Ysrraelit, María Célica; Correale, Jorge (Wiley Periodicals, 2025-08)
    Objective: Neuromyelitis optica spectrum disorder (NMOSD) is a severe autoimmune condition of the central nervous system (CNS), often associated with aquaporin-4 antibodies (AQP4-IgG). Rituximab, a CD20+ B-cell depleting ...
  • Integrated Workflow for Drug Repurposing in Glioblastoma: Computational Prediction and Preclinical Validation of Therapeutic Candidates 
    Gonzalez, Nazareno; Pérez Küper, Melanie; Garcia Fallit, Matías; Peña Agudelo, Jorge A.; Candia, Alejandro Nicola; Suarez Velandia, Maicol; Romero, Ana Clara; Videla Richardson, Guillermo Agustín; Candolfi, Marianela (MDPI, 2025-06-13)
    Background: Glioblastoma (GBM) remains a significant challenge in oncology due to its resistance to standard treatments including temozolomide. This study aimed to develop and validate an integrated model for predicting ...
  • Targeting FOXP3 in glioblastoma: Blockade of tumor intrinsic effects boosts response to chemo-radiotherapy 
    Garcia Fallit, Matías; Peña Agudelo, Jorge A.; Nicola Candia, Alejandro J.; Gonzalez, Nazareno; Pérez Küper, Melanie; Zampini, Yamila; Romero, Ana Clara; Sobarzo, Cristian; Sánchez Rojas, Ivana; Durán, Hebe; Perona, Marina; Ripari, Luisina Belén; Videla Richardson, Guillermo Agustín; Zanetti, Flavia A.; Lozano, Teresa; Casares, Noelia; Lasarte, Juan José; Candolfi, Marianela (Elsevier, 2025-06-27)
    Glioblastoma (GBM) is the most common malignant primary brain tumor in adults. Although this disease carries a dismal prognosis due to its highly invasive nature and resistance to therapy, no significant therapeutic advances ...
  • Prognostic Factors for Multiple Sclerosis Symptoms in Radiologically Isolated Syndrome 
    Fissolo, Nicolás; Schaedelin, Sabine; Villar, Luisa M.; Lünemann, Jan D.; Correale, Jorge; Rejdak, Konrad; Schwab, Nicholas; Vilaseca, Andreu; Held, Friederike; García-Merino, Antonio; Bittner, Stefan; Trojano, María; Furlan, Roberto; Tumani, Hayrettin; Pérez-Miralles, Francisco; Rosenstein, Igal; Galimberti, Daniela; Álvarez-Bravo, Gary; Thouvenot, Eric; Llufriu, Sara (American Medical Associatio, 2025-07-01)
    Importance: Understanding the risk factors for symptom development will allow clinicians to stratify people with radiologically isolated syndrome (pwRIS) more effectively and tailor their management strategies accordingl ...
  • Infusiones de ketamina a dosis subanestésicas en la depresión mayor resistente al tratamiento: protocolo de aplicación en un hospital público de Argentina 
    Dines, Micaela; Bulacia, Adriana; Bamondez, Paloma; Vega, Irene Luis; Montenegro, Micaela; Díaz, Pablo Germán; Oyhamburu, Paula; Ramos, Ana Laura; Ambrosio, Florencia; Vázquez, Gustavo; Pereyra, Monica; Pereyra, Hugo; Cichello, Cynthia; Ríos Merino, Laura Natalia (Polemos, 2025-07-10)
    La depresión mayor resistente al tratamiento (DMRT) representa un desafío significativo en psiquiatría, dada la limitada respuesta a las terapias convencionales. La ketamina endovenosa (EV) a dosis subanestésicas ha emergido ...

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